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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Role of DL-lactic acid as an intermediate in rumen metabolism of dairy cows显示文摘 | COUNOTTE G H M LANKHORST A PRINS R A | 1983 | Journal of Animal Science1983，56，： | 1 |
| 3 | Controls on terrigenous sediment supply to the Arabian Sea during the Late Quaternary : the Makran continental slope 显示文摘 | Prins M A Postma G Weltije G | 2000 | Marine Geology2000，169，： | 1 |
| 4 | Increased expression of the breast cancer resistance protein(BCRP)in relapsed or refractory acute myeloid leukemia(AML)显示文摘 | Van den Heuvel-Eibrink M Wiemer E Prins A | 2002 | Leukemia2002，16，5： | 1 |
| 5 | A 300-kyr record of aridity and wind strength in southwestern African : inference from grain-size distributions of sediments on Walvis Ridge, Southeast Atlantic 显示文摘 | Stuut J B Prins M A Schneider P R | 2002 | Marine Geology2002，180，： | 1 |
| 6 | Mechanisms of hydrodesulfurization and hydrodenitrogenation显示文摘 | PRINS R EGOROVA M R(O)THLISBERGER A ZHAO Y SIVASANKAR N KUKULA P | | 0，，1： | 1 |
| 7 | Particle segregation in fluidized binary mixtures显示文摘 | Hoffmann A C Janssen M L P B J Prins | 1993 | Chem Eng Sci1993，48，9： | 1 |
| 8 | Effects of climate,sea level,and tectonics unraveled for last deglaciation turbidite records of the Arabian Sea显示文摘 | Prins M A Postma G | 2000 | Geology2000，28，4： | 1 |
| 9 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
| 10 | Crystalline host phases for actinides, obtained by self-propagating high-temperature synthesis显示文摘 | GLAGOVSKII E M YUDINTSEV S V KU- PRIN A V | 2001 | Radionehemistry2001，43，6： | 1 |
| 11 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，1： | 1 |
| 12 | Proposal for a regenerative high-temperature process for coal gas cleanup withcalcined limestone 显示文摘 | vanderHam A G J Heesink A B M Prins W | 1996 | Industrial & Engineering Chemistry Research1996，35，5： | 1 |
| 13 | Genes prefereutially induced by depolarization after con-cussive brain injury: effects of age and injury sever- ity显示文摘 | GIZA C C PRINS M L HOVDA D A | 2002 | J Neurotrauma2002，19，4： | 1 |
| 14 | Controls on terrigenous sediment supply to the Arabian Sea during the late Quaternary:the Makran continental slope显示文摘 | PRINS M A POSTMA G WELTJE G J | 2000 | Marine Geology2000，169，： | 1 |
| 15 | Exergetic evaluation of biomass gasification显示文摘 | Ptasinski K J Prins M J Pierik A | 2007 | Energy2007，32，4： | 1 |
| 16 | Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs显示文摘 | Briejer M R Prins N H Schuurkes J A | 2001 | Neurogastroenterol Motil2001，13，： | 1 |
| 17 | The Late Quaternary sedimentary record on Reykjanes Ridge (North Atlantic)显示文摘 | PRINS M A TROELSTRA S R KRUK R W | 2001 | Radiocarbon2001，43，2： | 1 |
| 18 | Controls on the terrigenous sediment supply to the Arabian Sea during the late Quaternary:The Markran continental slope显示文摘 | Prins M A Postma G Weltje G | 2000 | Marine Geology2000，169，： | 1 |
| 19 | Ocean circulation and iceberg discharge in the glacial North Atlantic:inferences from unmixing of sediment distributions显示文摘 | PRINS M A BOUWER L M BEETS C J | 2002 | Journal of Geology2002，30，： | 1 |
| 20 | Regulation of lactate metabolism in the rumen显示文摘 | COUNOTFE G H M PRINS R A | 1981 | Veterinary Research Communi- cation1981，5，1： | 1 |
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