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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Engineered RNA-mediated resistance to tomato spotted wilt virus is sequence specific显示文摘 | DE OLIEEIRA RESENDE R ANKER C | 1996 | Mol Plant-Microbe Interact1996，9，： | 1 |
| 5 | Role of DL-lactic acid as an intermediate in rumen metabolism of dairy cows显示文摘 | COUNOTTE G H M LANKHORST A PRINS R A | 1983 | Journal of Animal Science1983，56，： | 1 |
| 6 | A 300-kyr record of aridity and wind strength in southwestern African : inference from grain-size distributions of sediments on Walvis Ridge, Southeast Atlantic 显示文摘 | Stuut J B Prins M A Schneider P R | 2002 | Marine Geology2002，180，： | 1 |
| 7 | Mechanisms of hydrodesulfurization and hydrodenitrogenation显示文摘 | PRINS R EGOROVA M R(O)THLISBERGER A ZHAO Y SIVASANKAR N KUKULA P | | 0，，1： | 1 |
| 8 | Carbon-supported sulfide catalysts显示文摘 | DUCHET J C Van OERS E M De BEER V H J PRINS R | 1983 | J Catal1983，80，2： | 1 |
| 9 | Preeclampsia is Associ- ated with lower Percentages of Regulatory T Cells in Maternal Blood 显示文摘 | Prins Jelmer R Boelens Hendrik M | 2009 | Hypertension in Pregnancy2009，28，3： | 1 |
| 10 | Mutual influence of the HDS of dibenzo- thiophene and HDN of 2-methylpyridine显示文摘 | Egorova M Prins R | 2004 | J Catal2004，221，1： | 1 |
| 11 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
| 12 | Mutual influence of the HDS of dibenzothiophene and HDN of 2-methylpyridine显示文摘 | EGOROVA M PRINS R | 2004 | J Catal2004，221，1： | 1 |
| 13 | Kinetics of the hydrodenitrogenation of orthopropylaniline over NiMo(P)/Al2O3 catalysts显示文摘 | Jian M Kapteijn F Prins R | 1997 | J Catal1997，168，2： | 1 |
| 14 | The emerging problem of tospovirus infection and nonconventional methods of control显示文摘 | Prins M Ooldbach R | 1998 | Trends in Microbiology1998，6，1： | 1 |
| 15 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 16 | Mechanism and kinetics of hydrodenitrogenation显示文摘 | PRINS R JIAN M FLECHSENHAr M | 1997 | Polyhedron1997，16，18： | 1 |
| 17 | Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs显示文摘 | Briejer M R Prins N H Schuurkes J A | 2001 | Neurogastroenterol Motil2001，13，： | 1 |
| 18 | The Late Quaternary sedimentary record on Reykjanes Ridge (North Atlantic)显示文摘 | PRINS M A TROELSTRA S R KRUK R W | 2001 | Radiocarbon2001，43，2： | 1 |
| 19 | Hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene over sulfided NiMo/gamma-Al2O3,CoMo/gamma-Al2O3,and Mo/gamma-Al2O3catalysts显示文摘 | Egorova M Prins R | | 0，，02： | 1 |
| 20 | The role of Ni and Co promoters in the simultaneous HDS of dibenzothiophene and HDN of amines over Mo/γ-Al2O3 catalysts显示文摘 | Prins R Egorova M | 2006 | Journal of Catalysis2006，241，1： | 1 |
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