|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence‐based international guide显示文摘 | A. P. S. Hungin C. Mulligan B. Pot P. Whorwell L. Agréus P. Fracasso C. Lionis J. Mendive J.‐M. Philippart de Foy G. Rubin C. Winchester N. Wit | 2013 | Aliment Pharmacol Ther2013，，8： | 4 |
| 3 | Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice显示文摘AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in mice.METHODS: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone treatment.RESULTS: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses. | Benot Foligné Jo■lle Dewulf Pascal Vandekerckove Georges Pignède Bruno Pot | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 4 | Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion显示文摘 | Nicolas Poté Fran?ois Cauchy Miguel Albuquerque Hélène Voitot Jacques Belghiti Laurent Castera Hervé Puy Pierre Bedossa Valérie Paradis | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Differentiation between 2,3-butanediol producing Bacillus licheniformis and Bacillus polymyxa strains by fermentation product profiles and whole-cell protein electrophorctic patterns显示文摘 | Raspoet D Pot B De Deyn D | 1991 | Syst Appl Microbiol1991，14，1： | 1 |
| 6 | Nucleotide variation in genes involved in wood formation in two pine species显示文摘 | POT D MCMILLAN L C C E | 2005 | New Phytol2005，167，1： | 1 |
| 7 | Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV显示文摘 | Catherine Daniel Florent Sebbane Sabine Poiret Denise Goudercourt Joelle Dewulf Chantal Mullet Michel Simonet Bruno Pot | 2008 | Vaccine2008，，8： | 1 |
| 8 | Nogo- A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury显示文摘 | Pot C Simonen M Weinmann O | 2002 | J Cell Siol2002，159，1： | 1 |
| 9 | Association between loss of heterozygosity of brca 1 and brca 2 and morphological attributes of sporadic braest cancer显示文摘 | Kelsoll DP Pots HW | 2000 | Int J Cancer2000，88，： | 1 |
| 10 | AFLP:a new technique for DNA fingerprinting显示文摘 | VOS P HOGERS R BLEEKER M REIJANS M VAN DE LEE T HORNES M FRIJTERS A POT J PELEMAN J KUIPER M ZABEAU M | 1995 | Nucleic Acids Research1995，23，21： | 1 |
| 11 | Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein显示文摘 | Benoit Foligne Rodrigue Dessein Michael Marceau Sabine Poiret Mathias Chamaillard Bruno Pot Michel Simonet Catherine Daniel | 2007 | Gastroenterology2007，，3： | 1 |
| 12 | Polyphasic taxonomy,a consensus approach to bacterial systematies显示文摘 | Vandamme P Pot B Gillis M De Vos P Kersters K &Swings J | 1996 | Mierobiol Rev1996，60，： | 1 |
| 13 | A comparison of NO and N2O production by the autotrop Hic nitrifier Nitorsomonas europaea and the heterotropHic nitrifier Alcaligenes faecalis显示文摘 | Anderson I C Pot H M Homstead J | 1993 | Appl Environ Microbiol1993，59，11： | 1 |
| 14 | Wireless sensor networks 显示文摘 | POT'FIE G KAISER W | 2000 | Communica- tions of the ACM2000，43，5： | 1 |
| 15 | Polyphasic taxonomy, a consensus approach to bacterial systematic 显示文摘 | Vandamme P Pot B Gillis M | 1996 | Microbi- ological Reviews1996，60，2： | 1 |
| 16 | Integrated map of AFLP, SSLP and RFLP markers using a recombinant inbred population of rice (Oryza sativa L.)显示文摘 | Y. G. Cho S. R. McCouch M. Kuiper M.-R. Kang J. Pot J. T. M. Groenen M. Y. Eun | 1998 | TAG Theoretical and Applied Genetics1998，，3： | 1 |
| 17 | The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27显示文摘 | Apetoh L Quintana FJ Pot C | 2010 | Nature Immunology2010，11，： | 1 |
| 18 | Polyghasic taxonomy, a consensus approach to bacterial systematics显示文摘 | Vandamme P Pot B Gillis M | 1996 | Microbiol Rev1996，60，2： | 1 |
| 19 | Life cycle assessment Part 2:Current impact assessment practice显示文摘 | Pennington D W Potting J Finnveden G | 2004 | Environ Int2004，30，5： | 1 |
| 20 | High responsivity GaN-based UV detectors显示文摘 | Potì B Todaro M T Frassanito M C | 2003 | IEEE Electronics Letters2003，39，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员