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| 1 | Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease显示文摘Antimicrobial peptides,including defensins,are essential effectors in host defence and in the maintenance of immune homeostasis.Clinical studies have linked the defective expression of both α-and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease(CD),respectively.Only recently have the events leading to defective expression of defensins in CD been further elucidated,and are discussed herein.These events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed patients.We also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD. | Mathias Chamaillard Rodrigue Dessein | 2011 | World Journal of Gastroenterology2011，17，5： | 5 |
| 2 | 洞庭湖区不同环境渔民血吸虫病肝纤维化调查显示文摘目的了解洞庭湖区不同血吸虫病流行环境渔民血吸虫病肝纤维化发生情况. 方法用便携式B超诊断仪对3种不同类型环境血吸虫病流行区的911名渔民进行肝实质及门脉纤维化分级诊断,使用Excel和SPSS 11.0作统计学分析.结果在3种不同类型环境中,洲垸型和洲岛型男性肝纤维化发生率均高于女性(P均〈0.01),但未定居型肝实质纤维化发生率男、女性差异无显著性(P>0.05).肝实质纤维化发生率依次为:未定居型>洲岛型>洲垸型,而肝门脉纤维化发生率依次为:洲岛型>未定居型>洲垸型.肝实质纤维化发生率洲垸型和洲岛型均以50~60岁年龄组为最高,未定居型以40~50岁年龄组为最高;肝门脉纤维化发生率洲垸型以60~岁年龄组为最高,洲岛型和未定居型均以30~40岁年龄组为最高.结论未定居型及洲岛型渔民肝纤维化程度重于洲垸型,需要加强对未定居型及洲岛型渔民的防治. | 喻鑫玲 罗新松 周杰 李俊 Alain Dessein 刘宗传 侯循亚 李岳生 | 2006 | 中国血吸虫病防治杂志2006，18，3： | 5 |
| 3 | Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis 显示文摘 | Dessein PH Joffe BI Stanwix AE | 2004 | Thyroid2004，14，6： | 1 |
| 4 | Improving the surface fin-ish of concave and convex surfaces using a ball burnishing process显示文摘 | Travieso J A Dessein G Rojas H A | 2011 | Materials and Manufacturing Processes2011，26，12： | 1 |
| 5 | Integration of dynamic behavior variations in the stability lobes method; 3Dlobes construction and application to thin-walled structure milling显示文摘 | THEVENOT V ARNAUD L DESSEIN G | 2006 | International Journal of Advanced Manufacturing Technology2006，27，： | 1 |
| 6 | Genetic epidemiology of infectious diseases in humans : Design of PoPulation - based studies 显示文摘 | Abel L Dessein AJ | 1998 | Emerg Infect Dis1998，4，4： | 1 |
| 7 | Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis显示文摘 | Dessein P H Joffe B I Stanwix A E | 2004 | Thyroid2004，14，： | 1 |
| 8 | Links between machining parameters and surface integrity in drilling ni-superalloy显示文摘 | Dutilh V Dessein G Alexis J | 2010 | International Journal of Advanced Materials Research2010，112，： | 1 |
| 9 | Surface roughness variation of thin wall milling, related to modal interactions显示文摘 | Seguy S Dessein Q Amaud L | 2008 | International Journal of Machine Tools & Manufacture2008，48，： | 1 |
| 10 | Investigation of tool failure- modes and machining disturbances using monitoring signals显示文摘 | Popa A Dessein G Baili M | 2012 | International Journal of Advanced Materials Research2012，423，： | 1 |
| 11 | Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein显示文摘 | Benoit Foligne Rodrigue Dessein Michael Marceau Sabine Poiret Mathias Chamaillard Bruno Pot Michel Simonet Catherine Daniel | 2007 | Gastroenterology2007，，3： | 1 |
| 12 | ,Authority and Communication in Organizations 显示文摘 | Dessein Wouter | 2002 | Review of Economic Studies2002，69，： | 1 |
| 13 | Links between machin- ing parameters and surface integrity in drilling ni-superalloy 显示文摘 | Dutilh V Dessein G Alexis J | 2010 | International Journal of Advanced Materials Research2010，112，： | 1 |
| 14 | Integration of dynamic behavior variations in the stability lobes method: 3D lobes construction and application to thin - walled structure mill- ing显示文摘 | Thevenot V Arnaud L Dessein G | 2006 | Int J Adv Manuf Technol2006，27，： | 1 |
| 15 | Investigation of tool fail- ure modes and machining disturbances using monitoring sig- nals显示文摘 | Popa A Dessein G Baili M | 2012 | International Journal of Advanced Materials Re- search2012，423，： | 1 |
| 16 | Induction of a pro tective immunity against Nchistosoma mansoni with ovalbumin-coupled Sm37-5 eoadsorbed with granulo- eyte-macrophage colony stimulating factor (GM-CSF) or IL2 on alum显示文摘 | Argirl L Henri S Dessein H | 1999 | Vaccine1999，17，1： | 1 |
| 17 | Influence of material removal on dynamic behavior of thin walled structure in peripheral milling显示文摘 | Thevenot V Arnaud L Dessein G | 2006 | Machining Science and Technology2006，10，3： | 1 |
| 18 | Side milling of ru- led surfaces: optimum positioning of the milling cutter and cal- culation of interference显示文摘 | REDONNET J M RUBIO W DESSEIN G | 1998 | International Journal of Advanced Manufacturing Technology1998，14，7： | 1 |
| 19 | High sensitivity C-reactiveprotein as a disease activity marker in rheumatoid arthritis显示文摘 | Dessein PH Joffe BI Stanwix AE | 2004 | JRheumatol2004，31，： | 1 |
| 20 | Nod-like receptors:cytosolic watchdogs for immunity against pathogens显示文摘 | Sirard JC Vignal C Dessein R | | 0，，： | 1 |
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