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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 3 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 4 | Split-dose bowel preparation improves adequacy of bowel preparation and gastroenterologists' adherence to National Colorectal Cancer Screening and Surveillance Guidelines显示文摘AIM To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps(< 10 mm).METHODS A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 years old with a normal screening colonoscopy and 1-2 small polyps. Data were abstracted from two time periods, pre and post-split-dose bowel preparation institution. Main outcome measurements were recommendation for timing of repeat colonoscopy and bowel preparation quality. Bivariate analysis by χ~2 tests and Student's t-tests were performed to assess differences between the two cohorts. Multivariable logistic regression was used with guideline consistent recommendations as the dependent variables and an indicator for 2011 cohort as the primary predictor. RESULTS Four thousand two hundred and twenty-five patients were included in the study; 47.0%(1987) prior to the institution of split dose bowel preparation, and 53.0%(2238) after the institution of split dose bowel preparation. Overall, 82.2%(n = 3472) of the colonoscopies were compliant with guideline recommendations, with a small but significantly increased compliance rate in year 2011(83.7%) compared to year 2009(80.4%, P = 0.005), corresponding to an unadjusted odds ratio of 1.25(95%CI: 1.07-1.47; P = 0.005). Colonoscopies with either 'Adequate' or 'Excellent' had increased from 30.6% in year 2009 to 39.6% in year 2011(P < 0.001). However, there was no significant difference in poor/inadequate category of bowel preparation as there was a mild increase from 4.6% in year 2009 to 5.1% in year 2011(P = 0.50). CONCLUSION Split-dose bowel regimen increases endoscopists' compliance to guidelines in average-risk patients with normal colonoscopy or 1-2 small polyps. | Stacy Bartnik Menees H Myra Kim Philip Schoenfeld | 2018 | World Journal of Gastroenterology2018，24，6： | 4 |
| 5 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 6 | Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis显示文摘 | Matthew D Edmonds Axel Cloeckaert Philip H Elzer | 2002 | Veterinary Microbiology2002，，3： | 3 |
| 7 | A survey of ampullectomy practices显示文摘AIM:To investigate the endoscopic ampullectomy practices of expert biliary endoscopists.METHODS:An anonymous survey was mailed to 79 expert biliary endoscopists to assess ampullectomy practices.RESULTS:Forty six(58%) biliary endoscopists returned the questionnaire.Of these, 63% were in academia and in practice for an average of 16.4 years(± 8.6).Endoscopists performed an average of 1.1(± 0.8) ampullectomies per month.Prior to ampullectomy, endoscopic ultrasound was'always'utilized by 67% of respondents vs'sometimes'in 31% of respondents.Empiric biliary sphincterotomy was not utilized uniformly, only 26%'always'and 37%'sometimes'performed it prior to resection.Fifty three percent reported'never'performing empiric pancreatic sphincterotomy prior to ampullectomy.Practitioners with high endoscopic retrograde cholangiopancreatography volumes were the most likely to perform a pancreatic sphincterotomy(OR = 10.9;P = 0.09).Participants overwhelmingly favored'always'placing a prophylactic pancreatic stent, with 86% placing it after ampullectomy rather than prior to resection(23%).Argon plasma coagulation was the favored adjunct modality(83%) for removal of residual adenomatous tissue.Practitioners uniformly(100%) preferred follow-up examination to be within 6 mo post-ampullectomy.CONCLUSION:Among biliary experts, there is less variation in ampullectomy practices than is reflected in the literature. | Stacy B Menees Philip Schoenfeld Hyungjin Myra Kim Grace H Elta | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 8 | Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago?显示文摘This review of the literature on small bowel carcinoma associated with Crohn's disease specifically addresses the incidence, risk factors, and protective factors which have been identified. It also reviews the clinical presentation, the current modalities of diagnosis, the pathology, treatment, and surveillance. Finally, the prognosis and future direction are addressed. Our experience with small bowel adenocarcinoma in Crohn's disease is reported. Readers will be provided with a better understanding of this rare and often poorly recognized complication of Crohn's disease. | Caitlin Cahill Philip H Gordon Andrea Petrucci Marylise Boutros | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 9 | Major outer membrane proteins of Brucella spp.: past, present and future显示文摘 | Axel Cloeckaert Nieves Vizca??no Jean-Yves Paquet Raúl A Bowden Philip H Elzer | 2002 | Veterinary Microbiology2002，，1： | 2 |
| 10 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 11 | Psychological benefits of greenspace increase with biodiversity显示文摘 | Fuller Richard A Irvine Katherine N Devine-Wright Patrick Warren Philip H Gaston Kevin J | 2007 | Biology Letters2007，，4： | 2 |
| 12 | Incorporation of esterified soybean isoflavones with antioxidant activity into low density lipoprotein显示文摘 | Meng Q H Philip L Kristiina W | 1999 | Biochim Biophys Acta1999，1438，3： | 1 |
| 13 | Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer 显示文摘 | BENOY I H E1ST H PHILIPS M | 2006 | Br J Cancer2006，94，5： | 1 |
| 14 | Global Danger Global Power显示文摘 | Gordon Philip H | 2002 | Air force magazine2002，22，11： | 1 |
| 15 | A Physical Model for On-Chip Spiral Inductors With Accurate Substrate Modeling显示文摘 | Huo X Philip C H Kevin J C | 2006 | IEEE Trans Electron Devices2006，53，12： | 1 |
| 16 | Pore-throat sizes in sandstones, tight sand-stones and shales显示文摘 | PHILIP H N | 2009 | AAPG Bulletin2009，，3： | 1 |
| 17 | Competing risks survival analysis applied to data from the Australian Orthopaedic Association National Joint Replacement Registry显示文摘 | Marianne H G Philip R Stephen E G | 2010 | Acta Orthopaedica2010，8，5： | 1 |
| 18 | Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer:10-year Results of the randomized boost versus no boost EORTC 22881-10882 trial显示文摘 | Harry B Jean-Claude H Philip M | 2007 | J Clin Oncol2007，25，： | 1 |
| 19 | Maximum andminimum temperature trends for the globe显示文摘 | David R E Briony H Philip D J | 1997 | Science1997，277，5324： | 1 |
| 20 | Effects of nitrogen source and UV radiation on the growth, chlorophyll fluorescence and fatty acid composition of Phaeodactylum tricornutum and Chaetoceros muelleri (Bacillariophyceae) 显示文摘 | Liang Y Beardall J Philip H | 2006 | Journal of Photochemistry and Photobiology2006，82，3： | 1 |
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