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1Congenital heart diseases trends in S?o Paulo State,Brazil:a national live birth data bank analysis显示文摘Background Congenital heart diseases(CHD)are the most common type of birth defects,affecting millions of newborns every year;no prevalence data are available in S?o Paulo State,Brazil's most populous state.The objective is to identify trends in prevalence and risk factors for CHD in Sao Paulo State,Brazil.Methods We developed a population-based study to estimate the CHD trend of prevalence in recent years,stratified by maternal age and geographical clusters,using all cases of CHD identified by the Live Births Information System(SINASC-Sistema de Informa??o Sobre Nascidos Vivos)from January 1,2005,to December 31,2018.We calculated the trends of prevalence,the regression coefficient(β),the annual percent change(APC),and 95%confidence interval using the Prais-Winsten regression model,with the Durbin-Watson test.Results We found 10,594 cases of CHD among 8,536,101 live births(LB),a prevalence of 12.4/10,000 LB.There was no difference in the sex distribution;they are primarily Caucasian(60.2%),75.2%born at term,and 74.4%weight>2500 g,66.9%of births were by cesarean section.S?o Paulo State presented an increasing CHD trend of prevalence(APC=18.9%).The highest CHD prevalence rate was in mothers aged≥35 years(22.2/10,000 LB).There were 12,271 specific congenital heart defects among 10,594 patients(1.16 CHD/patient).Atrial septal defect has the highest number of cases(3835),with a prevalence of 4.49/10,000 LB,corresponding to 31.3%of all CHD.Conclusion CHD had an increasing prevalence trend in recent years,being highest in S?o Paulo City and≥35-year mothers.Paola Soares Fernandes Larissa Rosario Magalhaes Tainara Rita Pezzini Edige Felipe de Sousa Santos Mauricio Giusti Calderon 2022World Journal of Pediatrics2022,18,7:3
2Stroke and depression: A bidirectional link显示文摘A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this association remains unclear. Numerous data have emerged suggesting an association between depressive symptoms and subsequent risk of stroke, thus leading to the hypothesis that a direct causality between depression and stroke exists. Notwithstanding, how depression may act as a risk factor for stroke is still unclear. Depression might be linked to stroke via neuroendocrine and inflammation effects, through correlation with major comorbidities such as hypertensionand diabetes or by intervention of lifestyle behavioral mediators. Finally, antidepressant medications have recently drawn attention for a possible association with increased risk of stroke, although such findings remain uncertain. Depression has been also established as an important consequence after stroke, exerting a significant adverse impact on the course of motor recovery, social functioning and, overall, on quality of life. Post stroke depression occurs in nearly one third of stroke cases, but the exact mechanism leading to depression after stroke is still incompletely understood. In this article, we will review contemporary epidemiologic studies, discuss potential mechanisms and specific aspects of the complex relation between depression and stroke.Elisabetta Del Zotto Paolo Costa Andrea Morotti Loris Poli Valeria de Giuli Alessia Giossi Irene Volonghi Antonio Callea Alessandro Padovani Alessandro Pezzini 2014World Journal of Meta-Analysis2014,2,3:2
3Cervical artery dissection: Trauma and other potential mechanical trigger events显示文摘Stefan T. Engelter Caspar Grond-Ginsbach Tiina M. Metso Antti J. Metso Manja Kloss Stephanie Debette Didier Leys Armin Grau Jean Dallongeville Marie Bodenant Yves Samson Valeria Caso Alessandro Pezzini Leo H. Bonati Vincent Thijs Henrik Gensicke Juan J. M 2013Neurology2013,,21:2
4Predictors of migraine subtypes in young adults with ischemic stroke:the italian project on stroke in young adults显示文摘Pezzini A Grassi M Lodigiani C 2011Stroke2011,42,1:1
5Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘Pezzini A Del Zotto E Archetti S 2002Stroke2002,33,:1
6Hasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘Pezzini A Del Zotto E Archetti S 2002Stroke2002,33,3:1
7Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘Pezzini A Del Zotto E Padovani A 2007Curr Med Chem2007,14,3:1
8No association of the-105 promoter polymorphism of the selenoprotein S encoding gene SEPSI with cerebrovascular disease 显示文摘Hyrenbach S Pezzini A Del Zotto E 2007Eur J Neurol2007,14,10:1
9Influence of acute blood pressure on short-and mid-term outcome of ischemic and hemorrhagic stroke显示文摘Pezzini A Grassi M Del Zotto E 2011J Neurol2011,258,4:1
10Plasma homocysteine concentration, C667T MTI-IFR genotype, and 844 ins 68bp CBS genotype in young adults with spontaneous artery dissec-tion and atherothrombotic stroke显示文摘Pezzini A Dd Zotto E Archetti S 2002Stroke2002,33,3:1
11Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘 Del Zotto E Padovani A 2007Curr Med Chem2007,14,3:1
12Homocysteine and cerehral ischemic:pathogenic and therapeutical implications显示文摘PEZZINI A DEL ZOTTO E PADOVANI A 0,,03:1
13Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘Pezzini A Zotto ED Padovani A CMC0,,:1
14Cerebral amyloid an- gio-patby: a common cause o显示文摘Pezzini A Del Zotto E Volonghi I 2009Curt Med Cbem2009,16,20:1
15Homocysteine and cer- ebral ischemia: pathogenic and therapeutical implications 显示文摘Pezzini A Del Zotto E Padovani A 2007Current Medicinal Chemistry2007,14,3:1
16Plasma homocysteine concentration,C677T MTHFR genotype,and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘Pezzini A Zotto ED Archetti S 2002Stroke2002,33,:1
17Homocysteine and cerebral ische-mia :pathogenic and therapeutical implications显示文摘Pezzini A Zotto ED Padovani A 2007CMC2007,14,3:1
18Cerebral amyloid angiopathy-related hemor-rhages 显示文摘Pezzini A Padovani A 2008Neurol Sci2008,29,2:1
19Homocysteine and cerebral is-chemia:pathogenic and therapeutical implications显示文摘Pezzini A Del Zotto E Padovani A 2007Curr Med Chem2007,14,3:1
20History of migraine and the risk of spontaneous cervical artery dissection 显示文摘Pezzini A Granella F Grassi M 2005Cephalalgia2005,25,8:1
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