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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | Stroke and depression: A bidirectional link显示文摘A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this association remains unclear. Numerous data have emerged suggesting an association between depressive symptoms and subsequent risk of stroke, thus leading to the hypothesis that a direct causality between depression and stroke exists. Notwithstanding, how depression may act as a risk factor for stroke is still unclear. Depression might be linked to stroke via neuroendocrine and inflammation effects, through correlation with major comorbidities such as hypertensionand diabetes or by intervention of lifestyle behavioral mediators. Finally, antidepressant medications have recently drawn attention for a possible association with increased risk of stroke, although such findings remain uncertain. Depression has been also established as an important consequence after stroke, exerting a significant adverse impact on the course of motor recovery, social functioning and, overall, on quality of life. Post stroke depression occurs in nearly one third of stroke cases, but the exact mechanism leading to depression after stroke is still incompletely understood. In this article, we will review contemporary epidemiologic studies, discuss potential mechanisms and specific aspects of the complex relation between depression and stroke. | Elisabetta Del Zotto Paolo Costa Andrea Morotti Loris Poli Valeria de Giuli Alessia Giossi Irene Volonghi Antonio Callea Alessandro Padovani Alessandro Pezzini | 2014 | World Journal of Meta-Analysis2014，2，3： | 2 |
| 3 | Effects of Composite β- and κ-Casein Genotypes on Milk Coagulation, Quality, and Yield Traits in Italian Holstein Cows显示文摘 | A. Comin M. Cassandro S. Chessa M. Ojala R. Dal Zotto M. De Marchi P. Carnier L. Gallo G. Pagnacco G. Bittante | 2008 | Journal of Dairy Science2008，，10： | 2 |
| 4 | An efficient and reusable catalyst based on Pd/CeOz for the room temperature aerobic Suzuki-Miyaura reaction in water/ethanol显示文摘 | AMOROSO F COLUSSI ZOTTO A DE | 2010 | Journal of Molecular Catalysis A: Chemical2010，315，19： | 1 |
| 5 | Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘 | Pezzini A Del Zotto E Archetti S | 2002 | Stroke2002，33，： | 1 |
| 6 | Hasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘 | Pezzini A Del Zotto E Archetti S | 2002 | Stroke2002，33，3： | 1 |
| 7 | Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘 | Pezzini A Del Zotto E Padovani A | 2007 | Curr Med Chem2007，14，3： | 1 |
| 8 | No association of the-105 promoter polymorphism of the selenoprotein S encoding gene SEPSI with cerebrovascular disease 显示文摘 | Hyrenbach S Pezzini A Del Zotto E | 2007 | Eur J Neurol2007，14，10： | 1 |
| 9 | Influence of acute blood pressure on short-and mid-term outcome of ischemic and hemorrhagic stroke显示文摘 | Pezzini A Grassi M Del Zotto E | 2011 | J Neurol2011，258，4： | 1 |
| 10 | Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestations 显示文摘 | Monastero R Bettini P Del Zotto E | 2001 | J Neurol Sci2001，184，： | 1 |
| 11 | Plasma homocysteine concentration, C667T MTI-IFR genotype, and 844 ins 68bp CBS genotype in young adults with spontaneous artery dissec-tion and atherothrombotic stroke显示文摘 | Pezzini A Dd Zotto E Archetti S | 2002 | Stroke2002，33，3： | 1 |
| 12 | Rat liver uncoupling protein 2:changes induced by a fructose- rich diet显示文摘 | CASTRO M C MASSA M L DEL ZOTTO H | 2011 | Life Sci2011，89，1718： | 1 |
| 13 | Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘 | Del Zotto E Padovani A | 2007 | Curr Med Chem2007，14，3： | 1 |
| 14 | Homocysteine and cerehral ischemic:pathogenic and therapeutical implications显示文摘 | PEZZINI A DEL ZOTTO E PADOVANI A | | 0，，03： | 1 |
| 15 | Homocysteine and cerebral ischemia:pathogenic and therapeutical implications显示文摘 | Pezzini A Zotto ED Padovani A | | CMC0，，： | 1 |
| 16 | Cerebral amyloid an- gio-patby: a common cause o显示文摘 | Pezzini A Del Zotto E Volonghi I | 2009 | Curt Med Cbem2009，16，20： | 1 |
| 17 | Homocysteine and cer- ebral ischemia: pathogenic and therapeutical implications 显示文摘 | Pezzini A Del Zotto E Padovani A | 2007 | Current Medicinal Chemistry2007，14，3： | 1 |
| 18 | Plasma homocysteine concentration,C677T MTHFR genotype,and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘 | Pezzini A Zotto ED Archetti S | 2002 | Stroke2002，33，： | 1 |
| 19 | Homocysteine and cerebral ische-mia :pathogenic and therapeutical implications显示文摘 | Pezzini A Zotto ED Padovani A | 2007 | CMC2007，14，3： | 1 |
| 20 | Homocysteine and cerebral is-chemia:pathogenic and therapeutical implications显示文摘 | Pezzini A Del Zotto E Padovani A | 2007 | Curr Med Chem2007，14，3： | 1 |
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