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| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | 尿酸与新发左心室肥厚:来自PAMELA人群的发现显示文摘血清尿酸水平与左心室肥厚(left ventricular hypertrophy,LVH)的相关性存在争议,血尿酸预测LVH发生的作用目前尚不清楚。本研究对PAMELA(pressioni arteriose monitorate E loro associazioni)研究的受试者进行为期10年的随访以评估血清尿酸与新发LVH的关系。 | Cuspidi C Facchetti R Bombelli M Sala C Tadic M Grassi G Mancia G 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 3 | Chronic rejection after liver transplantation:Opening the Pandora’s box显示文摘Chronic rejection(CR)of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation.Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy,CR still represents an important cause of graft injury,which might be irreversible,leading to graft loss requiring re-transplantation.To date,we still do not fully appreciate the mechanisms underlying this process.In addition to T cell-mediated CR,which was initially the only recognized type of CR,recently a new form of liver allograft CR,antibody-mediated CR,has been identified.This has indeed opened an era of thriving research and renewed interest in the field.Liver biopsy is needed for a definitive diagnosis of CR,but current research is aiming to identify new non-invasive tools for predicting patients at risk for CR after liver transplantation.Moreover,the minimization or withdrawal of immunosuppressive therapy might influence the establishment of subclinical CR-related injury,which should not be disregarded.Therapies for CR may only be effective in the“early”phases,and a tailored management of the immunosuppression regimen is essential for preventing irreversible liver damage.Herein,we provide an overview of the current knowledge and research on CR,focusing on early detection,identification of non-invasive biomarkers,immunosuppressive management,re-transplantation and future perspectives of CR. | Roberta Angelico Bruno Sensi Tommaso M Manzia Giuseppe Tisone Giuseppe Grassi Alessandro Signorello Martina Milana Ilaria Lenci Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 4 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 5 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 6 | Hydrophilic interaction liquid chromatography-APCI-mass spectrometry determi- nation of 5-fluorouracil in plasma and tissues 显示文摘 | Pisano R Breda M Grassi S | 2005 | J Pharm BiomedAnal2005，38，4： | 1 |
| 7 | Predictors of migraine subtypes in young adults with ischemic stroke:the italian project on stroke in young adults显示文摘 | Pezzini A Grassi M Lodigiani C | 2011 | Stroke2011，42，1： | 1 |
| 8 | Role of E2F1-Cyclin El-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs显示文摘 | Dapas B Farra R Grassi M | 2009 | Mol Med2009，15，910： | 1 |
| 9 | Self-emulsifiring pellets prepared by wet granulation in high-shear mixer: influence of formulation variables and preliminary study on the in vitro absorption显示文摘 | Francesehinis E Voinovich D Grassi M | 2005 | Int J Pharm2005，291，12： | 1 |
| 10 | Minimum power optimum control of microsatellite attitude dynamics 显示文摘 | GRASSI M PASTENA M | 2000 | Journal of Guidance Control and Dynamics2000，23，5： | 1 |
| 11 | Finite interlaminar delamination in element analyses of mode Ⅰ Z-fibre reinforced composite laminates 显示文摘 | Grassi M Zhang X | 2003 | Composites Science and Technology2003，63，12： | 1 |
| 12 | Thermal degradation of a series of polyester polyurethanes显示文摘 | Grassie N Zulfiqar M Guy M I | 1980 | Journal of Polymer Science Polymer Chemistry Edition1980，18，1： | 1 |
| 13 | Photosynthesis-nitrogen relationships: interpretation of different patterns between Pseudotsuga menziesii and Populus × ettroamericana in a ministand experiment显示文摘 | Ripullone F Grassi G Lauteri M Borghetti M | 2003 | Tree Physiol2003，23，： | 1 |
| 14 | Effects of polymer addition on the theology of o/w microemulsions显示文摘 | Lapasin R Grassi M N Coceani | 2001 | Rheol Acta2001，40，2： | 1 |
| 15 | No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees显示文摘 | Grassi E Mortilla M Amaducci L | 1996 | Neurosci Lett1996，206，223： | 1 |
| 16 | A method for the synchronization of hyperchaotic circuits显示文摘 | Brucoli M Carnimeo L Grassi G | 1996 | Int J Bifurcation Chaos1996，6，9： | 1 |
| 17 | Platelet - derived microvesicles in thrombotic thrombocytopenic purpura and hemolytic uremic Syndrome显示文摘 | Galli M Grassi A Barbui T | 1996 | Thrombo and Haemost1996，75，： | 1 |
| 18 | Influence of acute blood pressure on short-and mid-term outcome of ischemic and hemorrhagic stroke显示文摘 | Pezzini A Grassi M Del Zotto E | 2011 | J Neurol2011，258，4： | 1 |
| 19 | Detection of the M30 neoepitope as a new tool to quantify liver apoptosis:timing and patterns of positivity on frozen and paraffin-embedded sections显示文摘 | Grassi A Susca M Ferri S | 2004 | Am J Clin Pathol2004，121，2： | 1 |
| 20 | Diagnostic sensitivity of computer ized tomography in closed trauma of the diaphragm:Retrospective study of 35 consecutive cases显示文摘 | Scaglione M Pinto P Grassi R | 2000 | Radiol Med Torino2000，99，： | 1 |
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