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| 1 | Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms:Experience with Rifaximin显示文摘AIM:To estimate the prevalence of small intestinal bacterial overgrowth(SIBO) in our geographical area(Western Sicily,Italy) by means of an observational study,and to gather information on the use of locally active,non-absorbable antibiotics for treatment of SIBO.METHODS:Our survey included 115 patients fulfilling the Rome □ criteria for diagnosis of irritable bowel syndrome(IBS);a total of 97 patients accepted to perform a breath test with lactulose(BTLact),and those who had a positive test,received Rifaximin(Normix,Alfa Wassermann) 1200 mg/d for 7 d;3 wk after the end of treatment,the BTLact was repeated.RESULTS:Based on the BTLact results,SIBO was present in about 56% of IBS patients,and it was responsible for some IBS-related symptoms,such as abdominal bloating and discomfort,and diarrhoea.1-wk treatment with Rifaximin turned the BTLact to negative in about 50% of patients and significantly reduced the symptoms,especially in those patients with an alternated constipation/diarrhoea-variant IBS.CONCLUSION:SIBO should be always suspected in patients with IBS,and a differential diagnosis is done by means of a 'breath test'.Rifaximin may represent a valid approach to the treatment of SIBO. | Sergio Peralta Claudia Cottone Tiziana Doveri Piero Luigi Almasio Antonio Craxi | 2009 | World Journal of Gastroenterology2009，15，21： | 19 |
| 2 | untreatable hepatocellular 癌的自然历史: 回顾的队研究显示文摘 AIM:To investigate the clinical course of untreatable hepatocellular carcinoma(HCC) identified at any stage and to identify factors associated with mortality.METHODS:From January 1999 to December 2010,320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy.Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score.The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging.Data were collected for each patient including all clinical,laboratory and imaging variables necessary for the outcome prediction staging systems considered.HCC staging was performed according Barcelona Clinic Liver Cancer(BCLC) and Cancer of the Liver Italian Program scores.Follow-up time was defined as the number of months from the diagnosis of HCC to death.Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival.RESULTS:Seventy-five per cent of patients had hepatitis C.Ascites was present in 169 patients(53%),while hepatic encephalopathy was present in 49 patients(15%).The Child-Pugh score was class A in 105 patients(33%),class B in 142 patients(44%),and class C in 73 patients(23%).One hundred patients(31%) had macroscopic vascular invasion and/or extrahepatic spread of the tumor.A single lesion > 10 cm was observed in 34 patients(11%),while multinodular HCC was present in 189 patients(59%).Thirty nine patients(12%) were BCLC early(A) stage,55(17%) were BCLC intermediate(B) stage,124(39%) were BCLC advanced(C) stage,and 102(32%) were endstage BCLC(D).At the time of this analysis(July 2011),28(9%) patients were still alive.Six(2%) patients who were lost during follow-up were censored at the last visit.The overall median survival was 6.8 mo,and the 1-year survival was 32%.The 1-year survival according to BCLC classes was 100%,79%,12% and 0%,for BCLC A,B,C and D,respectively.There was a significant difference in survival between each BCLC class.The median survival of patients of BCLC stages A,B,C and D was 33,17.4,6.9,and 1.8 mo,respectively(P < 0.05 for comparison between stages).The median survival of Child-Pugh A,B and C classes were 9.8 mo(range 6.4-13),6.1(range 4.9-7.3),and 3.7(range 1.5-6),respectively(P < 0.05 for comparison between stages).By univariate analysis,the variables significantly associated to an increased liklihood of mortality were Eastern Cooperative Oncology Group performance status(PS),presence of ascites,low level of albumin,elevated level of bilirubin,international normalized ratio(INR) and Log-[(α fetoprotein(AFP)].At multivariate analysis,mortality was independently predicted by bad PS(P < 0.0001),high INR values(P = 0.0001) and elevated Log-(AFP) levels(P = 0.009).CONCLUSION:This study confirms the heterogeneous behavior of untreated HCC.BCLC staging remains an important prognostic guide and may be important in decision-making for palliative treatment. | Giuseppe Cabibbo Marcello Maida Chiara Genco Pietro Parisi Marco Peralta Michela Antonucci Giuseppe Brancatelli Calogero Cammà Antonio Craxì Vito Di Marco | 2012 | World Journal of Hepatology2012，4，9： | 11 |
| 3 | 心血管健康研究中血压轨迹与死亡率、心血管病事件和心力衰竭的关系显示文摘老年人的一般血压轨迹尚未明确,其与临床结局的关系也尚不确定。方法:本研究采用层次聚类分析法来确定心血管健康研究中4067参与者从0~7年重复测量血压值的血压轨迹。然后采用Cox比例风险回归模型评估每种血压轨迹聚类与全因死亡率、 | Smitson CC Scherzer R Shlipak MG Psaty BM Newman AB Sarnak MJ Odden MC Peralta CA 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 3 |
| 4 | The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C显示文摘 | Kathleen B. Schwarz Regino P. Gonzalez–Peralta Karen F. Murray Jean P. Molleston Barbara A. Haber Maureen M. Jonas Philip Rosenthal Parvathi Mohan William F. Balistreri Michael R. Narkewicz Lesley Smith Steven J. Lobritto Stephen Rossi Alexandra Valsamaki | 2011 | Gastroenterology2011，，2： | 2 |
| 5 | Use of advanced oxidation processes to improve the biodegradability of mature landfill leachates显示文摘 | Josmaria Lopes de Morais Patricio Peralta Zamora | 2005 | Journal of Hazardous Materials2005，，1： | 2 |
| 6 | Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu显示文摘 | Carmen Peralta Mónica B. Jiménez-Castro Jordi Gracia-Sancho | 2013 | Journal of Hepatology2013，，： | 2 |
| 7 | Role of ischemic preconditioning and the portosystemic shunt in the prevention of liver and lung damage after rat liver transplantation显示文摘 | Fernandez L Heredia N Peralta C | 2003 | Transplantation2003，76，2： | 1 |
| 8 | Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme - linked immunosorbent assay and flurescent antibody testing 显示文摘 | Yokoyama H Peralta R C Sendo S | 1993 | American Journal of Veterninary Research1993，54，： | 1 |
| 9 | Practical relative humidity systems that fissure rice and other grains显示文摘 | Kunze O R Peralta K | 1993 | Applied Engineering in Agriculture1993，，9： | 1 |
| 10 | Hepatic preconditioning preserves energy metabolism during sustained ischemia显示文摘 | Peralta C Bartrons R Riera L | 2000 | Am J Physiol2000，279，： | 1 |
| 11 | MicroRNA-143 regulates adipocyte differentiation显示文摘 | Esau C Kang X Peralta E | 2004 | J Biol Chem2004，279，52： | 1 |
| 12 | Tropical forest structure and composition on a large scale altitudinal gradient in Costa Ric显示文摘 | LIEBERMAN D LIEBERMAN M PERALTA R et 8-l | 1996 | Journal of Ecology1996，84，： | 1 |
| 13 | Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon:successful treatment with embolization and vincristine in two newborns显示文摘 | Garcia-Monaco R Giachetti A Peralta O | | 0，，03： | 1 |
| 14 | Reactive astrocytes promote the metastatic growth of breast cancer stem‐like cells by activating Notch signalling in brain显示文摘 | Fei Xing Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Andrew Wilber Yin‐Yuan Mo Brian E. Moore Wen Liu Koji Fukuda Megumi Iiizumi Sambad Sharma Yin Liu Kerui Wu Elizabeth Peralta Kounosuke Watabe | 2013 | EMBO Mol Med2013，，3： | 1 |
| 15 | Liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin显示文摘 | Peralta C Closa D Hotter G | 1996 | Biochem Biophys Res Commun1996，229，1： | 1 |
| 16 | HPV 16 E2 protein induces apoptosis in human and murine HPV 16 transformed epithelial cells and has antitumoral effects in vivo 显示文摘 | Bermtudez - Morales VH Peralta - Zaragoza O Guzman-Olea E | 2009 | Tumor Biol2009，30，2： | 1 |
| 17 | Simultaneous removal of soot and nitrogen oxides from diesel engine exhausts显示文摘 | Pisarello M L Milt V Peralta M A | 2002 | Catal Today2002，75，14： | 1 |
| 18 | Measles in Spain:its move into the adult population显示文摘 | Pena Rey Lorenzo I Santa Olalla Peralta P Amela Heras C | 2004 | Aten Primaria2004，33，4： | 1 |
| 19 | Fuzzy optimized self-organizing maps and their application to document clustering显示文摘 | ROMERO F P PERALTA A SOTO A | 2010 | Soft Computing-A Fusion of Foundations Methodologies and Applications2010，14，8： | 1 |
| 20 | Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia显示文摘 | Pasquini S Peralta S Missiaglia E | | 0，，08： | 1 |
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