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| 1 | Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way显示文摘Acute respiratory distress syndrome(ARDS) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52%. Recruitment maneuvers(RMs) are a simple, low-cost, feasible intervention that can be performed at the bedside in patients with ARDS. RMs are characterized by the application of airway pressure to increase transpulmonary pressure transiently. Once non-aerated lung units are reopened, improvements are observed in respiratory system mechanics, alveolar reaeration on computed tomography, and improvements in gas exchange(functional recruitment). However, the reopening process could lead to vascular compression, which can be associated with overinflation, and gas exchange may not improve as expected(anatomical recruitment). The purpose of this review was to discuss the effects of different RM strategies- sustained inflation, intermittent sighs, and stepwise increases of positive end-expiratory pressure(PEEP) and/or airway inspiratory pressure- on the following parameters: hemodynamics, oxygenation, barotrauma episodes, and lung recruitability through physiological variables and imaging techniques. RMs and PEEP titration are interdependent events for the success of ventilatory management. PEEP should be adjusted on the basis of respiratory system mechanics and oxygenation. Recent systematic reviews and meta-analyses suggest that RMs are associated with lower mortality in patients with ARDS. However, the optimal RM method(i.e., that providing the best balance of benefit and harm) and the effects of RMs on clinical outcome are still under discussion, and further evidence is needed. | Raquel S Santos Pedro L Silva Paolo Pelosi Patricia RM Rocco | 2015 | World Journal of Critical Care Medicine2015，4，4： | 19 |
| 2 | Ligand-binding properties of three odorant-binding proteins of the diamondback moth Plutella xylostella显示文摘Strategies for insect population control are currently targeting chemical communication at the molecular level. The diamondback moth Plutella xylostella represents one of the most serious pests in agriculture, however detailed information on the proteins mediating olfaction in this species is still poor. This species is endowed with a repertoire of a large number of olfactory receptors and odorant binding proteins(OBPs). As a contribution to map the specificities of these chemical sensors in the moth and eventually unrave l the complexity of chemodetection, we have measured the affinities of three selected OBPs to a series of potential odorants. Three proteins are highly divergent in their amino acid sequences and show markedly different expression profiles. In fact, PxylOBP3 is exclusively expressed in the antennae of both sexes, PxylOBP9 is male specific and present only in antennae and reproductive organs, while PxylOBP19, an unusual OBP with nine cysteines, is ubiquitously present in all the organs examined. Such expression pattern suggests that the last two proteins may be involved in non-chemosensory functions. Despite such differences, the three OBPs exhibit similar binding spectra, together with high selectivity. Among the 26 natural compounds tested, only two proved to be good ligands, retinol and coniferyl aldehyde. This second compound is particularly interesting being part of the chemical pathway leading to regeneration of lignin, one of the defense strategies of the plant against insect attack, and might find applications as a repellent for P. xylostella and other pests. | ZHU Jiao Paolo Pelosi LIU Yang LIN Ke-jian YUAN Hai-bin WANG Gui-rong | 2016 | Journal of Integrative Agriculture2016，15，3： | 3 |
| 3 | Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome显示文摘Considerable progress has been made over the last decades in the management of acute respiratory distress syndrome(ARDS).Mechanical ventilation(MV)remains the cornerstone of supportive therapy for ARDS.Lung-protective MV minimizes the risk of ventilator-induced lung injury(VILI)and improves survival.Several parame-ters contribute to the risk of VILI and require careful setting including tidal volume(V_(T)),plateau pressure(P_(plat)),driving pressure(ΔP),positive end-expiratory pressure(PEEP),and respiratory rate.Measurement of energy and mechanical power allows quantification of the relative contributions of various parameters(V_(T),P_(plat),ΔP,PEEP,respiratory rate,and airflow)for the individualization of MV settings.The use of neuromuscular blocking agents mainly in cases of severe ARDS can improve oxygenation and reduce asynchrony,although they are not known to confer a survival benefit.Rescue respiratory therapies such as prone positioning,inhaled nitric oxide,and extracorporeal support techniques may be adopted in specific situations.Furthermore,respiratory weaning protocols should also be considered.Based on a review of recent clinical trials,we present 10 golden rules for individualized MV in ARDS management. | Denise Battaglini Marco Sottano Lorenzo Ball Chiara Robba Patricia R.M.Rocco Paolo Pelosi | 2021 | Journal of Intensive Medicine2021，1，1： | 3 |
| 4 | Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study显示文摘 | Manu L. N. G. Malbrain Davide Chiumello Paolo Pelosi Alexander Wilmer Nicola Brienza Vincenzo Malcangi David Bihari Richard Innes Jonathan Cohen Pierre Singer Andre Japiassu Elizabeth Kurtop Bart L. De Keulenaer Ronny Daelemans Monica Del Turco P. Cosimin | 2004 | Intensive Care Medicine2004，，5： | 2 |
| 5 | Work climate, work values and professional commitment as predictors of job satisfaction in nurses显示文摘 | Luca Caricati Rachele La Sala Giuseppe Marletta Giulia Pelosi Monica Ampollini Anna Fabbri Alba Ricchi Marcello Scardino Giovanna Artioli Tiziana Mancini | 2014 | J Nurs Manag2014，，8： | 2 |
| 6 | Laparoscopic appendectomy using a single umbilical puncture (minilaparoscopy)显示文摘 | Pelosi MA Pelosi MA 3rd | 1992 | J Reprod Med1992，37，7： | 1 |
| 7 | Prevalence of intra-abdominal hypertension in critically ill patients:a multicentre epidemiological study显示文摘 | Malbrain ML Chiumello D Pelosi P | 2004 | Intensive Care Med2004，30，5： | 1 |
| 8 | Effects of the prone position on respiratory mechanics and gas exchange during acute lung injury显示文摘 | Pelosi P Tubiolo D | 1998 | Am J Respir Crit Care Med1998，157，： | 1 |
| 9 | Breast augmentation 显示文摘 | Pelosi MA 3rd Pelosi MA 2nd | 2010 | Obstet Gynecol Clin North Am2010，37，4： | 1 |
| 10 | Identification of the hemangioblast in postnatal life显示文摘 | Pelosi E Valtieri M Coppola S | | 0，，： | 1 |
| 11 | Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome显示文摘 | Gattinoni L Pelosi P Crotti S | 1995 | Am J Respir Crit Care Med1995，151，6： | 1 |
| 12 | Effect of different inspiratory rise time and cycling off criteria during pressure support ventilation in patients recovering from acute lung injury 显示文摘 | Chiumello D Pelosi P Taccone P | 2003 | Crit Care Med2003，31，： | 1 |
| 13 | Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients:a multiple-center epidemiological study显示文摘 | Malbrain ML Chiumello D Pelosi P | | 0，，02： | 1 |
| 14 | What has computed tomography taught us about the acute respiratory distress syndrome显示文摘 | Gattinoni L Caironi P Pelosi P | 2001 | Am J Re-spirCrit Care Med2001，164，9： | 1 |
| 15 | Combination of ra- diofrequency ablation and immunotherapy显示文摘 | Fagnoni FF Zerbini A Pelosi G | 2008 | Front Bios- ci2008，13，2： | 1 |
| 16 | Role of whole body positron emission tomography/eomputed tomography scan with 18F-fluorodeoxyglucose in patients with biopsy proven tumor metastases from unknown primary site显示文摘 | Pelosi E Pennone M Deandreis D | 2006 | Q J Nucl Med Mol Imaging2006，50，1： | 1 |
| 17 | Prognostic role of clinical and laboratory criteria to identify early ventilator-associated pneumonia in brain injury显示文摘 | Pelosi P Barassi A Severgnini P | 2008 | Chest2008，134，1： | 1 |
| 18 | Diversity of odorant-binding pro- teins and chemosensory proteins in insects 显示文摘 | Pelosi P Calvello M Ban L | 2005 | Chem Senses2005，30，1： | 1 |
| 19 | Pulmonary and extrapulmonary forms of acute respiratory distress syndrome 显示文摘 | PELOSI P CAIRONI P GATTINONI L | 2001 | Respir Crit Care Med2001，22，： | 1 |
| 20 | Clinical review:Positive end-expiratory pressure and cardiac output显示文摘 | Luecke T Pelosi P | 2005 | Crit Care Med2005，9，6： | 1 |
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