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| 1 | Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity显示文摘这评论研究的目的是阐明效果那磷酸二酯酶 5 (PDE5 ) 禁止者在精子上施加活动性, capacitation 过程并且在他们使肥沃的能力上卵母细胞。第二个送信人系统象 cAMP/adenylate cyclase (交流) 那样系统和 cGMP/guanylate cyclase (GC ) 系统看起来调整精子功能。intracytosolic 营地的增加的层次导致精子活动性和生存能力的改进。由氮的氧化物的低剂量的 GC 的刺激(没有) 导致精子活动性的改进或维护,而更高的集中在精子参数上有不利效果。几在活体内和在试管内研究被执行了以便检验 PDE5 禁止者是否断然或否定地影响精子参数和精子使肥沃能力。这些研究的结果是争论的。一些这些研究不在从与 PDE5 禁止者被对待的人收集的精子的活动性,生存能力,和形态学上表明 PDE5 禁止者的重要效果。在另一方面,几研究在精子活动性上表明 PDE5 禁止者的积极效果在活体内和在试管内。sildenafil 柠檬酸盐的在试管内研究随在除 PDE5 以外的 PDE 对碘氧基苯甲醚上建议 sildenafil 柠檬酸盐的一个禁止的行动的细胞内部的营地的增加在精子活动性上表明 stimulatory 效果。在另一方面, tadalafil 的行动看起来在 PDE11 上与这混合物的禁止的效果被联系。在在一个每日的基础与 vardenafil 对待的人的在活体内研究每精液,量的精子活动性,和质的精子活动性表明了精子的一个显著地更大的全部的数字;vardenafil 管理提高前列腺的能分泌的功能并且随后增加精子的质、量的活动性,这被建议了。PDE5 禁止者在精子参数上施加的效果可以导致帮助繁殖技术(艺术) 的结果的改进程序。在未来 PDE5,禁止者可能为男不孕的缓和用作附属物 therapeutical 代理人。 | F. Dimitriadis D. Giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.Tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis | 2008 | Asian Journal of Andrology2008，10，1： | 11 |
| 2 | Association of arterial stiffness with coronary flow reserve in revascularized coronary artery disease patients显示文摘AIM: To investigate the association of arterial wave reflection with coronary flow reserve(CFR) in coronary artery disease(CAD) patients after successful revascularization.METHODS: We assessed 70 patients with angiographically documented CAD who had undergone recent successful revascularization. We measured(1) reactive hyperemia index(RHI) using fingertip peripheral arterial tonometry(RH-PAT Endo-PAT);(2) carotid to femoral pulse wave velocity(PWVc-Complior);(3) augmentation index(AIx), the diastolic area(DAI%) and diastolic reflection area(DRA) of the central aortic pulse wave(Arteriograph);(4) CFR using Doppler echocardiography; and(5) blood levels of lipoprotein-phospholipase A2(LpPLA2).RESULTS: After adjustment for age, sex, blood pressure parameter, lipidemic, diabetic and smoking status, we found that coronary flow reserve was independently related to AIx(b =-0.38, r = 0.009), DAI(b = 0.36, P = 0.014), DRA(b = 0.39, P = 0.005) and RT(b =-0.29,P = 0.026). Additionally, patients with CFR < 2.5 had higher PWVc(11.6 ± 2.3 vs 10.2 ± 1.4 m/s, P = 0.019), SBPc(139.1 ± 17.8 vs 125.2 ± 19.1 mm Hg, P = 0.026), AIx(38.2% ± 14.8% vs 29.4% ± 15.1%, P = 0.011) and lower RHI(1.26 ± 0.28 vs 1.50 ± 0.46, P = 0.012), DAI(44.3% ± 7.9% vs 53.9% ± 6.7%, P = 0.008), DRA(42.2 ± 9.6 vs 51.6 ± 11.4, P = 0.012) and Lp PLA2(268.1 ± 91.9 vs 199.5 ± 78.4 ng/m L, P = 0.002) compared with those with CFR ≥ 2.5. Elevated Lp PLA2 was related with reduced CFR(r =-0.33, P = 0.001), RHI(r =-0.37, P < 0.001) and DRA(r =-0.35, P = 0.001) as well as increased PWVc(r = 0.34, P = 0.012) and AIx(r = 0.34, P = 0.001). CONCLUSION: Abnormal arterial wave reflections are related with impaired coronary flow reserve despite successful revascularization in CAD patients. There is a common inflammatory link between impaired aortic wall properties, endothelial dysfunction and coronary flow impairment in CAD. | Vlassis Tritakis Stavros Tzortzis Ignatios Ikonomidis Kleanthi Dima Georgios Pavlidis Paraskevi Trivilou Ioannis Paraskevaidis Giorgos Katsimaglis John Parissis John Lekakis | 2016 | World Journal of Cardiology2016，8，2： | 4 |
| 3 | Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease显示文摘 | Ignatios Ikonomidis Nikolaos N.P. Kadoglou Vlassis Tritakis Ioannis Paraskevaidis Kleanthi Dimas Paraskevi Trivilou Ioannis Papadakis Stavros Tzortzis Helen Triantafyllidi John Parissis Maria Anastasiou-Nana John Lekakis | 2014 | Atherosclerosis2014，，1： | 2 |
| 4 | Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial显示文摘 | Helen Athanassiou Dosia Antonadou Nikos Coliarakis Athina Kouveli Maria Synodinou Michalakis Paraskevaidis George Sarris Gregory R Georgakopoulos Katerina Panousaki Pantelis Karageorgis Nicolas Throuvalas | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，4： | 2 |
| 5 | Diagnostic accuracy of human papillomavirus testing in primary cervical screening: A systematic review and meta-analysis of non-randomized studies显示文摘 | George Koliopoulos Marc Arbyn Pierre Martin-Hirsch Maria Kyrgiou Walter Prendiville Evangelos Paraskevaidis | 2006 | Gynecologic Oncology2006，，1： | 2 |
| 6 | The role of HPVDNA testing in the follow-up period after treatment for CIN:A systematic review of the literature显示文摘 | Paraskevaidis El | 2004 | Can Treat Rew2004，30，： | 1 |
| 7 | Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases显示文摘 | Antonadou D Paraskevaidis M Sarris G | 2002 | J Clin Oncol2002，20，17： | 1 |
| 8 | Effective sleep apnoea treatment improves cardiac function in patients with chronic heart failure显示文摘 | Spiros P. Kourouklis Emmanouil Vagiakis Ioannis A. Paraskevaidis Dimitrios Farmakis Konstantinos Kostikas John T. Parissis Apostolos Katsivas Dimitrios T. Kremastinos Maria Anastasiou-Nana Gerasimos Filippatos | 2012 | International Journal of Cardiology2012，，： | 1 |
| 9 | Anti-infammatory and anti-apoptotic effects of levosimendan in decomensated heart failure:a novel mechnism of drug-induced improvement in contractile performance of the failing heart显示文摘 | Paraskevaidis IA Parissis JT Kremastions D | 2005 | Curr Med Chem Cardiovasc Hematol Agent2005，3，3： | 1 |
| 10 | The effect of acute administration of statins on coronary microcircutation during the pre- revascularization period in patients with myocardial infraction显示文摘 | Paraskevaidis 1 A lliodromitis E K Ikonomidis I | 2012 | Atheroscleros is2012，223，1： | 1 |
| 11 | Treating volume overload in acutely decompensated heart failure: established and novel therapeutic approaches 显示文摘 | Koniari K Parissis J Paraskevaidis I | 2012 | Eur Heart J Aute Cardiovasc Care2012，1，3： | 1 |
| 12 | Treating depression in coronary artery disease and chronic heart failure:what's new in using selective serotonin re-uptake inhibitors?显示文摘 | PARASKEVAIDIS I PALIOS J PARISSIS JG | 2012 | Cardiovasc Hematol Agents Med Chem2012，10，2： | 1 |
| 13 | Delivery outcomes following loop electrosurgical excision procedure for micro invasive (FIGO stage IA1) cervical cancer显示文摘 | Paraskevaidis E Koliopoulos G Lolis E | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 14 | The role of HPV DNA testing in the follow-up period after treatment for CIN : a systematic review of the literature 显示文摘 | Paraskevaidis E Arbyn M Sotiriadis A | 2004 | Cancer Treat Rev2004，30，： | 1 |
| 15 | Transesophageal detection of early systolic reverse pulmonary venous flow in atrial fibrillation显示文摘 | Paraskevaidis IA Kremastinos DT Matsakas EP | 1994 | Am J Cardiol1994，73，5： | 1 |
| 16 | Combined approach for the early detection of ovarian,cancer in asymptomatic women Eur显示文摘 | Adonakis GL Paraskevaidis E Tsiga S | 1996 | J obstet Report Biol1996，65，： | 1 |
| 17 | The role of HPV DNA testing in the follow - up period after treatment for CIN: A systematic review of the literature显示文摘 | Paraskevaidis E Arbyn M Sotiriadis A | 2004 | Cancer Treat Rev2004，30，： | 1 |
| 18 | Repeated exercise stress testing identifies early and late preconditioning 显示文摘 | Paraskevaidis I A Iliodomtis E K Mavrogeni S | 2005 | Int J Cardiol2005，98，2： | 1 |
| 19 | Delivery outcomes Lollowing loop electrosurgical excision procedure for microinvasive (FIGO stage Ⅰ a1) cervical cancer显示文摘 | Paraskevaidis E Koliopoulos G Lolis E | 2002 | Gynecol Oncol2002，86，： | 1 |
| 20 | Phase Ⅱ randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases显示文摘 | Antonadou D Paraskevaidis M Sarris G | 2002 | J Clin Oncol2002，20，： | 1 |
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