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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Grain boundary structure effects on cold work embrittlement of microanoyed steels 显示文摘 | Lehockey E M Palumbo G Lin P | 1998 | Scripta Mater1998，39，3： | 1 |
| 3 | On a More Restrictive Geometric Criterion for 'Special' CSL Grain Boundaries显示文摘 | Palumbo G Aust K T Lehockey E M | 1998 | Scr Mater1998，38，11： | 1 |
| 4 | Thermodynamic analysis of the stable and metastable Co-Cu andCo-Cu-Fe phase diagrams显示文摘 | PALUMBO M CURIOTTO S BATTEZZATI L | 2006 | Calphad2006，30，： | 1 |
| 5 | Analysis of the creep strength of a low-carbon AISI 304 steel with low-Σ grain boundaries 显示文摘 | Spigarelli S Cabibbo M Evangelista E Palumbo G | 2003 | Materials Science and Engineering A2003，352，： | 1 |
| 6 | Smoothmusde cells in human atheroscle-rotic plaques secrete and proliferate in response to high mobility group box 1 protein显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB J2006，20，： | 1 |
| 7 | Influence of inheritance and pedogenesis on heavy metal distribution in soils of Sicily,Italy显示文摘 | Palumbo B Angelone M Bellanca A | 2000 | Geoderma2000，95，： | 1 |
| 8 | DNA topoisomerase IIstructures and anthracycline activity: insights into ternary com-plex formation显示文摘 | Dal Ben D Palumbo M Zagotto G | 2007 | Curr Pharm Des2007，13，27： | 1 |
| 9 | Diagnostic and Prognostic Role of HBME-1,Galectin-3,and β-Catenin in Poorly Differentiated and Anaplastic Thyroid Carcinomas显示文摘 | Rossi ED Straccia P Palumbo M | 2013 | Appl Immunohistochem Mol Morphol2013，21，4： | 1 |
| 10 | Energy consumption in RC tree circuits显示文摘 | Alioto M Palumbo G Poli M | | 0，，： | 1 |
| 11 | Progressive lacunar stroke : Re- view of mechanisms, prognostic features, and putative treatments显示文摘 | Del Bene A Palumbo V Lamassa M | 2012 | Int JStroke2012，7，4： | 1 |
| 12 | The effect ofacid strength on the conversion of methanol to olefins overacidic microporous catalysts with the CHA topology 显示文摘 | BLEKEN F BJ覫RGEN M PALUMBO L | 2009 | Topicsin Catalysis2009，52，3： | 1 |
| 13 | Simultaneous recovery of RNA and DNA from soils and sediments 显示文摘 | HURT R A QIU X WU L ROH Y PALUMBO A V TEIDJE J M ZHOU J | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 14 | Smooth muscle cells in human atherosclerotic plaques secrete and proliferate in response to high mobility group box 1 protein 显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB2006，20，14： | 1 |
| 15 | Continuous lenalido- mide treatment for newly diagnosed multiple myeloma 显示文摘 | Palumbo A Hajek R Delforge M | 2012 | N Engl J Med2012，366，19： | 1 |
| 16 | Prevention of thalidomide-associated thrombosis in myeloma显示文摘 | Palumbo A Rajkumar S V Dimopoulos M A | | 0，，： | 1 |
| 17 | Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation显示文摘 | Palumbo R Sampaolesi M De Marchis F | 2004 | J Cell Biol2004，164，3： | 1 |
| 18 | Grain Boundary Structure Effects on Cold Work Embrittlement of Microalloyed Steel显示文摘 | Lehockey E M Palumbo G Lin P | 1998 | Scripta Materialia1998，39，3： | 1 |
| 19 | On the creep behaviour of grain boundary engineered nickel 显示文摘 | Lehoekey E M Palumbo G | 1997 | Mater Sci Eng1997，237，2： | 1 |
| 20 | Design criteria for cooperating robots assembly cells显示文摘 | Pelagagge P M Cardarelli G Palumbo M | 1995 | J of Manufacturing Systems1995，14，4： | 1 |
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