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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Thermodynamic analysis of the stable and metastable Co-Cu andCo-Cu-Fe phase diagrams显示文摘 | PALUMBO M CURIOTTO S BATTEZZATI L | 2006 | Calphad2006，30，： | 1 |
| 3 | Emerging roles of microRNA in modulating cell-death processes in malignant glioma显示文摘 | Palumbo S Miracco C Pirtoli L | 2014 | J Cell Physiol2014，229，3： | 1 |
| 4 | The effect ofacid strength on the conversion of methanol to olefins overacidic microporous catalysts with the CHA topology 显示文摘 | BLEKEN F BJ覫RGEN M PALUMBO L | 2009 | Topicsin Catalysis2009，52，3： | 1 |
| 5 | Simultaneous recovery of RNA and DNA from soils and sediments 显示文摘 | HURT R A QIU X WU L ROH Y PALUMBO A V TEIDJE J M ZHOU J | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 6 | Use of starter cultures in meats显示文摘 | James Smith L Samuei Palumbo A | 1983 | Joumal of Food Proteetion1983，46，： | 1 |
| 7 | Numerical/experimental investigations for enhancing the sheet hydroforming process 显示文摘 | Palumbo G Zhang S H Tricarico L | 2006 | International Journal of Machine Tools & Manufacture2006，46，： | 1 |
| 8 | Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments显示文摘 | Palumbo S Pirtoli L Tini P | 2012 | J Cell Biochem2012，113，7： | 1 |
| 9 | Biases in The Perception and Affective Valence of Neutral FacialExpressions Induced by The Immediate Perceptual History 显示文摘 | Jellema T Pecchinenda A Palumbo L | 2011 | Visual Cognition2011，19，5： | 1 |
| 10 | Spontaneous hematogenous and lymphatic metastasis, hut not primary tumor growth or angiogenesis, is diminished in t'ibrinogen-deficient mice显示文摘 | Palumbo J S Potter J M Kaplan L S | 2002 | Cancer Res2002，62，23： | 1 |
| 11 | Numerical finite element investigation on laser cladding treatment of ring geometries显示文摘 | Palumbo G Pinto S Tricarico L | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 12 | Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults显示文摘 | Pasqualini D Bergandi L Palumbo L | 2012 | J Endod2012，38，12： | 1 |
| 13 | Histology of micropolyps in chronic endometritis显示文摘 | Resta L Palumbo M Rossi R | 2012 | Histopathology2012，60，4： | 1 |
| 14 | Harmonic analysis of non-linear structures by means of generalized frequency response functions coupled with NARX models显示文摘 | PALUMBO P PIRODDI L | 2000 | Mechanical Systems and Signal Processing2000，14，2： | 1 |
| 15 | Numerical and experimental investigations on the warm deep drawing process of circular aluminum alloy specimens显示文摘 | PALUMBO G TRICARICO L | 2007 | Journal of Materials Processing Technology2007，184，13： | 1 |
| 16 | Lowdose thalidomide plus Dexamethasone is an effective salvage therapy for advanced myeloma显示文摘 | PALUMBO A GIACCONE L BERTOLA A | 2001 | Hematologica2001，86，： | 1 |
| 17 | Emergence of fluoroquinolone-resistant tuberculosis in New York City 显示文摘 | Sullivan EA Kreiswirth BN Palumbo L | 1995 | Lancet1995，345，8958： | 1 |
| 18 | Resistance of field strains of beet armyworm (Lepidoptera:Noctuidae) from arizona and california to carbamate insecticides显示文摘 | Kerns D L Palumbo J C Tellez T | 1998 | Journal of Economic Entomology1998，91，5： | 1 |
| 19 | Response of marine bacterioplankton to differential filtration and confinement显示文摘 | Ferguson R L Buckley E N Palumbo A V | 1984 | Applied and Environmental Microbi- ology1984，47，1： | 1 |
| 20 | Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial 显示文摘 | Palumbo A B ringhen S Caravita T et a l | 2006 | Lancet2006，367，9513： | 1 |
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