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| 1 | Non-invasive diagnostic imaging of colorectal liver metastases显示文摘Colorectal cancer is one of the few malignant tumors in which synchronous or metachronous liver metastases [colorectal liver metastases(CRLMs)] may be treated with surgery. It has been demonstrated that resection of CRLMs improves the long-term prognosis. On the other hand, patients with un-resectable CRLMs may benefit from chemotherapy alone or in addition to liverdirected therapies. The choice of the most appropriate therapeutic management of CRLMs depends mostly on the diagnostic imaging. Nowadays, multiple non-invasive imaging modalities are available and those have a pivotal role in the workup of patients with CRLMs. Although extensive research has been performed with regards to the diagnostic performance of ultrasonography, computed tomography, positron emission tomography and magnetic resonance for the detection of CRLMs, the optimal imaging strategies for staging and follow up are still to be established. This largely due to the progressive technological and pharmacological advances which are constantly improving the accuracy of each imaging modality. This review describes the non-invasive imaging approaches of CRLMs reporting the technical features, the clinical indications, the advantages and the potential limitations of each modality, as well as including some information on the development of new imaging modalities, the role of new contrast media and the feasibility of using parametric image analysis as diagnostic marker of presence of CRLMs. | Pier Paolo Mainenti Federica Romano Laura Pizzuti Sabrina Segreto Giovanni Storto Lorenzo Mannelli Massimo Imbriaco Luigi Camera Simone Maurea | 2015 | World Journal of Radiology2015，7，7： | 13 |
| 2 | Radiomics and machine learning applications in rectal cancer:Current update and future perspectives显示文摘The high incidence of rectal cancer in both sexes makes it one of the most common tumors,with significant morbidity and mortality rates.To define the best treatment option and optimize patient outcome,several rectal cancer biological variables must be evaluated.Currently,medical imaging plays a crucial role in the characterization of this disease,and it often requires a multimodal approach.Magnetic resonance imaging is the first-choice imaging modality for local staging and restaging and can be used to detect high-risk prognostic factors.Computed tomography is widely adopted for the detection of distant metastases.However,conventional imaging has recognized limitations,and many rectal cancer characteristics remain assessable only after surgery and histopathology evaluation.There is a growing interest in artificial intelligence applications in medicine,and imaging is by no means an exception.The introduction of radiomics,which allows the extraction of quantitative features that reflect tumor heterogeneity,allows the mining of data in medical images and paved the way for the identification of potential new imaging biomarkers.To manage such a huge amount of data,the use of machine learning algorithms has been proposed.Indeed,without prior explicit programming,they can be employed to build prediction models to support clinical decision making.In this review,current applications and future perspectives of artificial intelligence in medical imaging of rectal cancer are presented,with an imaging modality-based approach and a keen eye on unsolved issues.The results are promising,but the road ahead for translation in clinical practice is rather long. | Arnaldo Stanzione Francesco Verde Valeria Romeo Francesca Boccadifuoco Pier Paolo Mainenti Simone Maurea | 2021 | World Journal of Gastroenterology2021，27，32： | 10 |
| 3 | Colorectal cancer and 18FDG-PET/CT:What about adding the T to the N parameter in loco-regional staging?显示文摘AIM:To evaluate whether FDG-positron emission tomography(PET)/computed tomography(CT)may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS:Thirty four consecutive patients(20 men and 14 women;mean age:63 years)with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages(≤T2,T3,T4).Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS:Thirty five/37(94.6%)adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%(95%CI:87%-100%).All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION:Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer. | Pier Paolo Mainenti Delfina Iodice Sabrina Segreto Giovanni Storto Mario Magliulo Giovanni Domenico De Palma Marco Salvatore Leonardo Pace | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 4 | Splenic hypoperfusion as a sign of systemic amyloidosis显示文摘 | Mainenti PP Camera L Nicotra S | 2005 | Abdom Imaging2005，30，6： | 1 |
| 5 | Hepatic splenic amy -loidosis: dual - phase spiral CT findings显示文摘 | Mainenti PP D Agostino L Soscia E | 2003 | Abdom Imaging2003，28，5： | 1 |
| 6 | Rare diffuse peri- toneal malignant neoplasms: CT findings in two cases显示文摘 | Mainenti PP Romano L Contegiacomo A | 2003 | Abdom Imaging2003，28，6： | 1 |
| 7 | Tomographic imaging of the spleen : the role of morphological and metabolic features in dif- ferentiating benign from malignant diseases 显示文摘 | Mainenti PP Iodice D Cozzolino I et at | 2012 | Clin Imaging2012，36，5： | 1 |
| 8 | Multideteetor row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease:dingnostic accuracy and interobserver agreement显示文摘 | Romano M Mainenti PP lmbriaco M | 2004 | Eur J Radiol2004，50，3： | 1 |
| 9 | PET/CT colonography in patients with colorectal polyps:a feasibility study显示文摘 | Mainenti PP Salvatore B D' Antonio D | | 0，，10： | 1 |
| 10 | Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease:diagnostic accuracy and interobserver agreement显示文摘 | RAMANO M MAINENTI PP IMBRIACO M | 2004 | Eur J Radiol2004，50，3： | 1 |
| 11 | Triphasic helical CT in Budd-Chiari syndrome: patterns of enhancement in acute, subacute and chronic disease显示文摘 | Camera L Mainenti PP Di Giacomo A | 2006 | Clin Radiol2006，61，4： | 1 |
| 12 | Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer显示文摘 | Pier Paolo Mainenti Luigi Carlo Cirillo Luigi Camera Francesco Persico Teresa Cantalupo Leonardo Pace Giovanni Domenico De Palma Giovanni Persico Marco Salvatore | 2006 | European Journal of Radiology2006，，3： | 1 |
| 13 | Muhidetector row CT angiography of the ab- dominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagonstic accuranc and intelobserver agreement 显示文摘 | Romano M Mainenti PP Imb riaco M | 2004 | Eur JRadiol2004，50，1： | 1 |
| 14 | Nuclear imaging to characterize adrenal tumors: Comparison with MRI显示文摘AIM:To describe the role of nuclear imaging modalities using nor-cholesterol,metaiodobenzylguanidine(MIBG)and fluorine-deoxy-glucose(FDG)in adrenal tumors for lesion characterization in comparison with magnetic resonance(MR).METHODS:Population was classified in group 1 consisting of 30 patients with non-hypersecreting unilateral adrenal masses,in group 2 consisting of 34 patients with hypersecreting(n=19)or non-hypersecreting(n=15)adrenal adenomas and in group 3 consisting of 18 patients with chromaffin-tissue tumors(CTT),of which 14 were pheochromocytomas while 4 were paragangliomas(n=4).All patients underwent MR and nuclear studies(nor-cholesterol,MIBG and FDG).Pathology samples(n=63)or follow-up data in adenomas(n=19)were used as standard of reference forimaging studies interpretation.RESULTS:In group 1,MR findings were not highly accurate for lesion characterization,while the results of nuclear scans showed abnormal nor-cholesterol,MIBG and FDG concentration in all cases of adenomas,pheos and malignant tumors,respectively.In group 2,no differences in MR parameters were found between hyperfunctioning and non-hyperfunctioning adenomas,while nor-cholesterol uptake was significantly higher in hyperfunctioning compared to non-hyperfunctioning lesions.In group 3,no differences in MR parameters were found between benign and malignant CCT,while MIBG uptake was significantly higher in malignant compared to benign tumors.CONCLUSION:On the basis of our findings,nuclear imaging modalities using specific target agents are able to better characterize adrenal tumors,compared with MR.In particular,radionuclide techniques are able to identify the nature of adrenal incidentalomas and to differentiate between hypersecreting and non-hypersecreting adenomas as well as between benign and malignant CTT. | Simone Maurea Pier Paolo Mainenti Valeria Romeo Carmine Mollica Marco Salvatore | 2014 | World Journal of Radiology2014，6，7： | 1 |
| 15 | Rare Diffuse Peritoneal Malignant Neoplasms CT Finding in two Cases显示文摘 | Mainenti PP Romano L Contegiacomo A | 2003 | Abdominal Imaging2003，28，6： | 1 |
| 16 | Diffusion volume (DV) measurement in endometrial and cervical cancer:a new MRI parameter in the evaluation of the tumor grading and the risk classification 显示文摘 | Mainenti PP Pizzuti LM Segreto S | 2016 | European Journal of Radiol- ogy2016，85，1： | 1 |
| 17 | Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease:diagonstic accurancy and interobserver agreement 显示文摘 | Romano M Mainenti PP Imbriaco M | 2004 | Eur J Radiol2004，50，1： | 1 |
| 18 | Triphasic helical CT in Budd-Chiari syndrome: patterns of en- hancement in acute, subaeute and chronic disease显示文摘 | CAMERA L MAINENTI PP DI GIACOMO A | 2006 | Clin Radiol2006，61，4： | 1 |
| 19 | Splenic hypoperfusion as a sign of systemic amyloidosis显示文摘 | Mainenti PP Camera L Nicotra S | 2005 | Abdom Imaging2005，30，6： | 1 |
| 20 | Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease显示文摘 | Perrone-Filardi P Mainenti PP | 1998 | J Nucl Cardiol1998，5，15： | 1 |
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