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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype 显示文摘 | Legro RS Chiu P Kunselman AR | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 3 | Role of tissue - plasminogen activator in a mouse model of neonatal white matter lesions : Interaction with plasmin inhibitors and anti - inflammatory drugs 显示文摘 | Leroux P Hennebert O Legros H | 2007 | Neuroscience2007，146，2： | 1 |
| 4 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
| 5 | Opinion of Belgian neurologists on antiepileptic drugs: Belgian Study on Epilepsy Treatment (BESET) 显示文摘 | Legros B Boon P Dejonghe P | 2007 | Acta Neurol Scand2007，115，2： | 1 |
| 6 | Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls显示文摘 | LEGRO R S CASTRACANE V D KAUFFMAN R P | 2004 | Obstetrical and Gynecological Survey2004，59，2： | 1 |
| 7 | Usefulness of prolonged video-EEG monitoring and provocative procedure with saline injection for the diagnosis of non-epileptic seizures of psychogenic origin显示文摘 | Ribai P Tugendhaft P Legros B | 2006 | J Neurol2006，253，3： | 1 |
| 8 | Detecting insulin resistance in polycystic ovary syndrome:Purposes and pitfalls显示文摘 | Legro R S Castracane V D Kauffman R P | 2004 | Obstet Gynecol Surv2004，59，2： | 1 |
| 9 | Computer Aided Design of Synthetic Test Circuit for High Voltage Circuit-brcakers 显示文摘 | Legros W P Genon M M Morant P G | 1989 | IEEE Transactions on Power Delivery1989，4，2： | 1 |
| 10 | Structural study and electrical conductivity of salts based on functional- ized TI'F containing peripheral selenium atoms 显示文摘 | Kaboub L Legros J P Donnadieu B | 2004 | J Mater Chem2004，14，： | 1 |
| 11 | Methods to determine aerobic endurance显示文摘 | SQUET L L LEGER P LEGROS | 2002 | Sports Med2002，32，11： | 1 |
| 12 | Reactive Compatibilization of Polyester/Vinyl Acetate Copolymer Blends: Rheological, Morphological and Mechanical Proper-ties显示文摘 | Legros A Carreau P J Favis B D Michd A | 1994 | Polymer1994，35，4： | 1 |
| 13 | Characterization and modelling of ageing failures on power MOSFET devices显示文摘 | Khong B Legros M Tounsi P | 2007 | Microelectronics Reliability2007，47，： | 1 |
| 14 | Characterization and modeling of ageing failures on power MOSFET devices 显示文摘 | KHONG B LEGROS M TOUNSI P | 2007 | Microelectronics and reliability2007，47，： | 1 |
| 15 | Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype 显示文摘 | Legro RS Chiu P Kunselman AR | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 16 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
| 17 | Functional characterization of novel mutations in the human cytochrome b gene显示文摘 | Legros F Chatzoglou E Frachon P | | 0，，07： | 1 |
| 18 | Blood Lactate Response to Overtraining in Male Endurance Athletes显示文摘 | Bosquet L L6ger L Legros P | 2001 | Eur J Appl Physio12001，84，12： | 1 |
| 19 | Methods to determineaerobic endurance显示文摘 | BOSQUET L L LEGER P LEGROS | 2002 | Sports Med2002，32，11： | 1 |
| 20 | Letrozole,gonadotropin,or clomiphene for unexplained infertility 显示文摘 | Diamond M P Legro R S Coutifaris C | 2015 | NEngl J M ed2015，373，： | 1 |
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