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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum显示文摘 | Donald Nuss Robert E Kelly Daniel P Croitoru Michael E Katz | 1998 | Journal of Pediatric Surgery1998，，4： | 4 |
| 4 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 5 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 6 | WONCA研究论文摘要汇编——全科医疗问诊中占主导地位的非语言交流的简单干预随机控制试验显示文摘背景改变问诊中非语言行为的影响并不明朗。目的评估占问诊主导地位的非语言交流的简短医生培训。设计和场所进行整群随机平行组试验,在南安普敦市研究协调中心附近的全科医疗诊所中选取年龄≥16岁的全科医生。方法 16名全科医生随机分为培训组和非培训组,培训包括对一项前期行为研究结果的简短介绍〔研究结果的缩略词为KEPe Warm,含义如下:展现对患者的了解;鼓励(例如说"嗯"来发出反馈信号)〕;肢体参与(碰触、手势、稍稍前倾);预热:冷静/专业的开场,预热,避免疏远和问诊结束时的非言语收场和鼓励医生对问诊录像进行回顾。以医学访问满意量表(MISS)项目平均得分(1~7分)和患者对交流其他方面的认知为试验指标。结果培训组MISS整体得分高于非培训组〔OR=0.23,95%CI(0.06,0.41)〕;其中,痛苦减轻、关系认知分量表的得分提高最多;交流/合作认知得分〔OR=0.29,95%CI(0.09,0.49)〕和健康提升得分〔OR=0.26,95%CI(0.05,0.46)〕显著提高,私人关系认知、积极方法和了解疾病对生活影响的得分提高不显著。结论占问诊主导地位的非语言交流的简短医生培训和问诊录像回顾能够提升患者满意度、减轻痛苦、促进合作方法认知和健康提升。 | Little P White P Kelly J 本刊编辑部 | 2015 | 中国全科医学2015，18，21： | 2 |
| 7 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 8 | Effects of Ischemia and Reperfusion on Subpopulations of Rat Enteric Neurons Expressing the P2X7 Receptor显示文摘 | Kelly Palombit Cristina Eusébio Mendes Wothan Tavares-de-Lima Mariana Póvoa Silveira Patricia Castelucci | 2013 | Digestive Diseases and Sciences2013，，12： | 2 |
| 9 | GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories 显示文摘 | Jacobson L H Kelly P H Bettler B | 2006 | J Neurosci2006，26，34： | 1 |
| 10 | Demonstrating the intrinsic ion channel activity of virally encoded proteins显示文摘 | Kelly ML Cook JA Brown-Auqsburger P | 2003 | FEBS Letters2003，552，1： | 1 |
| 11 | Magnetron sputtering;a review of recent development and applications显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 12 | Team learning in medical education: initial experiences at ten institutions 显示文摘 | Searle NS Haidet P Kelly PA etc | 2003 | Acad Med2003，78，： | 1 |
| 13 | 显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 14 | Unmetabolized folic acid in serum : acute studies in subjects consuming fortified food and supple- ments 显示文摘 | Kelly P McPartlin J Gogglns M | 1997 | Am J Clin Nun''1997，65，： | 1 |
| 15 | Polyelectrolytes as in- clusions in electrorheologically active materials: Effect of chemical characteristics on ER actirity materials and mecha- nisms in electrorheology显示文摘 | BLOCK H KELLY J P QIN A | 1990 | Langmuir1990，6，： | 1 |
| 16 | Surface alloying of AZ91D alloy by diffusion coating显示文摘 | Zhang M X Kelly P M | 2002 | J Mater Res2002，17，： | 1 |
| 17 | Caspase 3 activity is required for skeletal muscle differentiation显示文摘 | Fernando P Kelly JF Megeney LA | 2002 | PNAS2002，99，11： | 1 |
| 18 | Identification of XAF1 as an antagonist of XIAP and-Caspase activity显示文摘 | Liston P Fong WG Kelly NL | 2001 | Nat Cell Biol2001，3，2： | 1 |
| 19 | A thermomechanical analysis of a family of soil models 显示文摘 | Collins I F Kelly P A | 2002 | Geotechnique2002，52，7： | 1 |
| 20 | Ultrafine gained ferrite formed by interrupted hottorsion of plain carton steel显示文摘 | Kelly G L Beladi H Hedgson P | 2002 | ISIJ International2002，42，12： | 1 |
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