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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 3 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 4 | Nanosecond-to-femtosecond laser-induced breakdown in dielectrics显示文摘 | STUART B C FEIT M D HERMAN S | 1996 | Phys Rew B1996，53，： | 2 |
| 5 | Housing wealth,fi-nancial wealth,and consumption:New evidence from microdata显示文摘 | Raphael B Stuart G Gary P | 2009 | Regional Science and Urban Economics2009，，： | 1 |
| 6 | High precision sampling for chromatographic separation显示文摘 | Barry E B Stuart P C Leitner J E | 1973 | Anal Chem1973，45，14： | 1 |
| 7 | Tribological studies of poly (ether ether ketone)blends 显示文摘 | B H Stuart | 1998 | Tribology International1998，31，11： | 1 |
| 8 | Early events in integrin ανβ6-mediated cell entry of foot-and-mouth disease virus显示文摘 | STEPHEN B STUART C MONAGHAN P | 2005 | J Virol2005，79，13： | 1 |
| 9 | Nanosecond-tofemtosecond laser-induced breakdown in dielectrics显示文摘 | STUART B C FEIT M D HERMAN S | 1996 | Phys Rev B1996，53，4： | 1 |
| 10 | Aging, obsolescence and or- ganizational innovation 显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，： | 1 |
| 11 | Amoxicillin for acute lower- re- spiratory -tract infection in primary care when pneumonia is not sus- pected : a 12 - country, randomised, placebo - controlled trial 显示文摘 | Little P Stuart B Moore M | 2013 | Lancet Infect Dis2013，13，2： | 1 |
| 12 | Cooperation and competition in pathogenic bacteria显示文摘 | ASHLEIGH S G STUART A W ANGUS B | 2004 | Letters to Nature2004，430，10： | 1 |
| 13 | Steroid hormone influence on brain calbindin-D28k in male prepubertal and ovariectomized rats显示文摘 | Stuart E B Thompson J M Rhees R W | 2001 | Developmental Brain Research2001，129，2： | 1 |
| 14 | Analysis of mineral fillers and mastics used in stone matrix asphalt显示文摘 | Harris B M Stuart K D | 1995 | Proceed- ings Association of Asphalt Paving Technologists1995，64，1： | 1 |
| 15 | A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload 显示文摘 | Stuart I Michael B Dmitri S | 2011 | Journal of Controlled Release2011，155，3： | 1 |
| 16 | Aging, obsolescence and organizational innovation显示文摘 | Srensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 17 | Scratch hardness studies of Poly (etheretherketone) 显示文摘 | Stuart B H Briseoe B J | 1996 | Polymer1996，37，17： | 1 |
| 18 | Protein method department of biochemistry university of genera显示文摘 | Stuart J E | 1997 | Genera Switzerland1997，，： | 1 |
| 19 | Petawatt laser pulses显示文摘 | Perry M D Pennington D Stuart B C | 1999 | Opt Lett1999，24，3： | 1 |
| 20 | Boards, CEOs, and Surviving a Financial Crisis: Evidence from the Internet Shakeout 显示文摘 | DOWELL G W S SHACKELL M B STUART N V | 2011 | Strategic Management Journal2011，32，10： | 1 |
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