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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Novel scheme for the preparation of transmission electron microscopy specimens with a focused ion beam 显示文摘 | OVERWIJK M VAN DEN HEUVEL F BULLE‐LIEUWMA C | 1993 | Journal of Vacuum Science & Technology B1993，11，6： | 1 |
| 3 | T-cell receptor gene therapy of established tumors in a murine melanoma model显示文摘 | Abad JD Wrzensinski C Overwijk W | 2008 | J immunother2008，31，1： | 1 |
| 4 | Conference Scene: Immune effector mechanisms in tumor immunity 显示文摘 | Sikora AG Hailemichael Y Overwijk WW | 2012 | Immunotherapy2012，4，2： | 1 |
| 5 | Vaccination with a recombi-nant vaccinia virus encoding a ”self” antigen induces autoimmune vitili-go and tumor cell destrustion in mice: Requirement for CD4 ( + ) Tlymphocytes显示文摘 | Overwijk WW Lee DS Surman DR | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 6 | Tumor Regres sion and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8^+ T Cells 显示文摘 | Overwijk WW Theoret MR Finkelstein SE | 2003 | Journal of Experimental Medicine2003，198，4： | 1 |
| 7 | Harnessing the power of the immune system to target cancer 显示文摘 | Lizée G Overwijk WW Radvanyi L | 2013 | Annu Rev Med2013，64，： | 1 |
| 8 | Human CD1+ T cells spontaneously detect so-matic mutations in cancer cells显示文摘 | Overwijk WW | 2015 | Nature Med2015，21，1： | 1 |
| 9 | T-cell receptor gene therapy of established tumors in a murine melanoma model显示文摘 | Abad JD Wrzensinski C Overwijk W | 2008 | J Immunother2008，31，1： | 1 |
| 10 | Tumor regression and autoimmunity after reversal of a functionally tolerant state of self- reactive CD8^+ T cells 显示文摘 | Overwijk WW Theoret MR Rosenberg SA | 2003 | J Exp Med2003，198，4： | 1 |
| 11 | T- cell receptor gene therapy of established tumors in a murine melanoma model 显示文摘 | Abad JD Wrzensinski C Overwijk W | 2008 | J Immunother2008，31，1： | 1 |
| 12 | Harnessing the power of the immune system to target cancer显示文摘 | Lizfe G Overwijk W W Radvanyi L | 2013 | Annu Rex Med2013，64，： | 1 |
| 13 | Vaccination with a recombi- nant vaccinia virus encoding a 'self' antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CIM ( + ) Tlymphocytes显示文摘 | Overwijk W W Lee D S Surman D R | 1999 | Proc Natl Acad Sci1999，96，： | 1 |
| 14 | Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8 + T cells 显示文摘 | Overwijk WW Theoret MR Finkelstein SE | 2003 | J Exp Med2003，198，4： | 1 |
| 15 | ApoptoticdeathofCD8+Tlymphocytes after immunization:induction of asuppressivepopulationofMac-1+/Gr-1+ cells显示文摘 | Bronte V Wang M Overwijk WW | 1998 | J Immunol1998，161，： | 1 |
| 16 | Cutting edge:CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen显示文摘 | Dudley ME Overwijk WW | 2000 | J Immuno12000，164，： | 1 |
| 17 | Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant显示文摘 | Overwijk WW Visser KE Tirion FH | 2006 | J Immunol2006，176，： | 1 |
| 18 | The future of interleukin - 2:enhancing therapeutic anticancer vaccines显示文摘 | Overwijk WW Theoret MR Restifo NP | 2000 | Cancer J Sci Am2000，6，1： | 1 |
| 19 | The future of interleukin-2:enhancing therapeutic anticancer vaccines显示文摘 | Overwijk WW Theoret MR Restifo NP | | 0，，1： | 1 |
| 20 | Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms显示文摘 | Lizee G Radvanyi LG Overwijk WW | | 0，，： | 1 |
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