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| 1 | Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C显示文摘We have previously reported that Cystatin C(CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen(HBO) preconditioning; however,the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. As a marker of autophagy inhibition, p62 was downregulated by HBO preconditioning and this was blocked by CysC knockdown. Besides, the beneficial effects of preserving lysosomal membrane integrity and enhancing autolysosome formation induced by HBO preconditioning were abolished in CysC-/-rats.Furthermore, we demonstrated that exogenous CysC reduced the neurological deficits and infarct volume after brain ischemic injury, while 3-methyladenine partially reversed this neuroprotection. In the present study, we showed that CysC is biochemically and morphologically essential for promoting autophagic flux, and highlighted the translational potential of HBO preconditioning and CysC for stroke treatment. | Zongping Fang Yun Feng Yuheng Li Jiao Deng Huang Nie Qianzhi Yang Shiquan Wang Hailong Dong Lize Xiong | 2019 | Neuroscience Bulletin2019，35，2： | 14 |
| 2 | Trust Management Mechanism for Internet of Things显示文摘Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P,Grid,ad hoc network and so on.However,few researches about trust mechanism for Internet of Things(IoT) could be found in the literature,though we argue that considerable necessity is held for applying trust mechanism to IoT.In this paper,we establish a formal trust management control mechanism based on architecture modeling of IoT.We decompose the IoT into three layers,which are sensor layer,core layer and application layer,from aspects of network composition of IoT.Each layer is controlled by trust management for special purpose:self-organized,affective routing and multi-service respectively.And the final decision-making is performed by service requester according to the collected trust information as well as requester' policy.Finally,we use a formal semantics-based and fuzzy set theory to realize all above trust mechanism,the result of which provides a general framework for the development of trust models of IoT. | GU Lize WANG Jingpei SUN Bin | 2014 | China Communications2014，11，2： | 4 |
| 3 | Retina-Inspired Organic Heterojunction-Based Optoelectronic Synapses for Artificial Visual Systems显示文摘For the realization of retina-inspired neuromorphic visual systems which simulate basic functions of human visual systems,optoelectronic synapses capable of combining perceiving,processing,and memorizing in a single device have attracted immense interests.Here,optoelectronic synaptic transistors based on tris(2-phenylpyridine)iridium(Ir(ppy)_(3))and poly(3,3-didodecylquarterthiophene)(PQT-12)heterojunction structure are presented.The organic heterojunction serves as a basis for distinctive synaptic characteristics under different wavelengths of light.Furthermore,synaptic transistor arrays are fabricated to demonstrate their optical perception efficiency and color recognition capability under multiple illuminating conditions.The wavelength-tunability of synaptic behaviors further enables the mimicry of mood-modulated visual learning and memorizing processes of humans.More significantly,the computational dynamics of neurons of synaptic outputs including associated learning and optical logic functions can be successfully demonstrated on the presented devices.This work may locate the stage for future studies on optoelectronic synaptic devices toward the implementation of artificial visual systems. | Junyao Zhang Yang Lu Shilei Dai Ruizhi Wang Dandan Hao Shiqi Zhang Lize Xiong Jia Huang | 2021 | Research2021，，1： | 3 |
| 4 | Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma:a matched comparative study显示文摘Background:To compare two types of therapy for primary breast carcinoma,breast-conserving therapy(BCT) and modified radical mastectomy(MRM),in a matched cohort study.Methods:A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence(LR),distant metastasis,and survival.The patients were matched with regard to age at diagnosis,spreading to axillary lymph nodes,hormone receptor status,the use of neoadjuvant chemotherapy and maximal tumor diameter.The match ratio was 1:1,and each arm included 873 patients.Results:The median follow-up period was 71 months.The 6-year disease-free survival(DFS) and 6-year distant disease-free survival(DDFS) rates differed significantly between two groups.The 6-year local recurrence-free survival(LRFS) rates were 98.2% [95% confidence interval(CI):0.973-0.989] in the BCT group and 98.7%(95% CI:0.980-0.994) in the MRM group(P=0.182),respectively.DFS rates in BCT and MRM groups were 91.3%(95% CI:0.894-0.932) and 86.3%(95% CI:0.840-0.886)(P<0.001),respectively,whereas the DDFS rates in BCT and MRM groups were 93.6%(95% CI:0.922-0.950) and 87.7%(95% CI:0.854-0.900)(P<0.001),respectively.Conclusions:BCT in eligible patients is as effective as MRM with respect to local tumor control,DFS and DDFS,and may result in a better outcome than MRM in Chinese primary breast cancer patients. | Lize Wang Tao Ouyang Tianfeng Wang Yuntao Xie Zhaoqing Fan Benyao Lin Jinfeng Li | 2015 | Chinese Journal of Cancer Research2015，27，6： | 3 |
| 5 | Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart显示文摘Cannabinoid receptor type 2(CB2)activation is recently reported to promote proliferation of some types of resident stem cells(e.g.,hematopoietic stem/progenitor cell or neural progenitor cell).Resident cardiac progenitor cell(CPC)activation and proliferation are crucial for endogenous cardiac regeneration and cardiac repair after myocardial infarction(MI).This study aims to explore the role and possible mechanisms of CB2receptor activation in enhancing myocardial repair.Our results revealed that CB2receptor agonist AM1241 can significantly increase CPCs by c-kit and Runx1 staining in ischemic myocardium as well as improve cardiomyocyte proliferation.AM1241 also decreased serum levels of MDA,TNF-αand IL-6 after MI.In addition,AM1241 can ameliorate left ventricular ejection fraction and fractional shortening,and reduce fibrosis.Moreover,AM1241 treatment markedly increased p-Akt and HO-1 expression,and promoted Nrf-2 nuclear translocation.However,PI3K inhibitor wortmannin eliminated these cardioprotective roles of AM1241.In conclusion,AM1241 could induce myocardial regeneration and improve cardiac function,which might be associated with PI3K/Akt/Nrf2 signaling pathway activation.Our findings may provide a promising strategy for cardiac endogenous regeneration after MI. | WANG YaBin MA Sai WANG Qiang HU WenXing WANG DongJuan LI XiuJuan SU Tao QIN Xing ZHANG XiaoTian MA Ke CHEN JiangWei XIONG LiZe CAO Feng | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 6 | A Modeling Language Based on UML for Modeling Simulation Testing System of Avionic Software显示文摘With direct expression of individual application domain patterns and ideas,domain-specific modeling language(DSML) is more and more frequently used to build models instead of using a combination of one or more general constructs.Based on the profile mechanism of unified modeling language(UML) 2.2,a kind of DSML is presented to model simulation testing systems of avionic software(STSAS).To define the syntax,semantics and notions of the DSML,the domain model of the STSAS from which we generalize the domain concepts and relationships among these concepts is given,and then,the domain model is mapped into a UML meta-model,named UML-STSAS profile.Assuming a flight control system(FCS) as system under test(SUT),we design the relevant STSAS.The results indicate that extending UML to the simulation testing domain can effectively and precisely model STSAS. | WANG Lize LIU Bin LU Minyan | 2011 | Chinese Journal of Aeronautics2011，24，2： | 2 |
| 7 | Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta‐analysis显示文摘 | Judith J Korterink Lize Ockeloen Marc A Benninga Merit M Tabbers Mirrian Hilbink Judith M Deckers‐Kocken | 2014 | Acta Paediatr2014，，4： | 2 |
| 8 | Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice显示文摘General anesthesia severely affects the metabolites in the brain.Glycogen,principally stored in astrocytes and providing the short-term delivery of substrates to neurons,has been implicated as an affected molecule.However,whether glycogen plays a pivotal role in modulating anesthesia-arousal remains unclear.Here,we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain regions.Glycogen synthase(GS)and glycogen phosphorylase(GP),key enzymes of glycogen metabolism,showed increased activity after isoflurane exposure.Upon blocking glycogenolysis with 1,4-dideoxy-1,4-imino-Darabinitol(DAB),a GP antagonist,we found a prolonged time of emergence from anesthesia and an enhancedδfrequency in the EEG(electroencephalogram).In addition,augmented expression of glycogenolysis genes in glycogen phosphorylase,brain(Pygb)knock-in(PygbH11/H11)mice resulted in delayed induction of anesthesia,a shortened emergence time,and a lower ratio of EEG-δ.Our findings revealed a role of brain glycogen in regulating anesthesiaarousal,providing a potential target for modulating anesthesia. | Ze Fan Zhihao Zhang Shiyi Zhao Yuanyuan Zhu Dong Guo Bo Yang Lixia Zhuo Jiao Han Rui Wang Zongping Fang Hailong Dong Yan Li Lize Xiong | 2020 | Neuroscience Bulletin2020，36，12： | 2 |
| 9 | Plasmacytoid dendritic cellsinduce NK cell-dependent,tumor antigen-specific T cellcross-priming and tumor regression in mice显示文摘 | Liu C Lou Y Lizee G | 2008 | J Clin Invest2008，118，3： | 1 |
| 10 | E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis显示文摘 | Lize M Pilarski S Dobbelstein M | 2010 | Cell Death Differ2010，17，3： | 1 |
| 11 | Less yin, more yang: confronting the barriers to cancer immunotherapy 显示文摘 | LIZEE G CANTU MA HWU P | 2007 | Clin Cancer Res2007，13，181： | 1 |
| 12 | Males do not prolong copulation in response to com- petitor males in the polyandrous fly Drosophila bifasciata显示文摘 | Lize A Price T Marcello M Smaller E A Hurst GDD | 2012 | Physiological Entomology2012，37，3： | 1 |
| 13 | TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity显示文摘 | Qiang Wang Xingchun Gou Weilin Jin Lize Xiong Lichao Hou Shaoyang Chen Hui Zhang Xiaoling Zhu Lixian Xu | 2009 | Cellular and Molecular Neurobiology2009，，： | 1 |
| 14 | Active PAI-1 as marker for venous thromboembolism: ease-control study using a comprehensive panel of PAI-1 and TAFI assays 显示文摘 | Lize B Marijke P Miet P | 2014 | Thromb Res2014，134，5： | 1 |
| 15 | Motor inhibition efficiency in healthy aging: the role of γ-aminobutyric acid显示文摘The ability to cancel a motor response is critical for optimal functioning in various facets of daily life. Hence, efficient inhibitory motor control is a key function throughout the lifespan. Considering the fact that inhibitory motor function gradually declines with advancing age, it is not surprising that the study of motor inhibition in this age group is gaining considerable interest. In general, we can distinguish between two prominent types of motor inhibition, namely proactive and reactive inhibition. Whereas the anticipation for upcoming stops(proactive inhibition) appears readily preserved at older age, the ability to stop an already planned or initiated action(reactive inhibition) generally declines with advancing age. The differential impact of aging on proactive and reactive inhibition at the behavioral level prompts questions about the neural architecture underlying both types of inhibitory motor control. Here we will not only highlight the underlying structural brain properties of proactive and reactive inhibitory control but we will also discuss recent developments in brain-behavioral approaches, namely the registration of neurochemical compounds using magnetic resonance spectroscopy. This technique allows for the direct detection of the primary inhibitory neurotransmitter in the brain, i.e., γ-aminobutyric acid, across the broader cortical/subcortical territory, thereby opening new perspectives for better understanding the neural mechanisms mediating efficient inhibitory control in the context of healthy aging. Ultimately, these insights may contribute to the development of interventions specifically designed to counteract age-related declines in motor inhibition. | Lisa Pauwels Celine Maes Lize Hermans Stephan P.Swinnen | 2019 | Neural Regeneration Research2019，14，5： | 1 |
| 16 | Attemtaed/2ste n-smocywger reptvgrmm M2-polarized ttan-assodated maerophages in ovarian cancer leading to iNOS-mediated tumor cell lysis 显示文摘 | Lize P H Baird J R Stever C A | 2014 | Oncoimmunology2014，3，28： | 1 |
| 17 | The seletive tyro- sine kinase inhibitor STI 571 inhibits small cell lung canc- er growth 显示文摘 | Krystal GW Honsawek S Lize J | 2000 | Clin Cancer Res2000，6，8： | 1 |
| 18 | Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice显示文摘 | Liu CW Lou YY Lizee G | 2008 | J Clin Invest2008，118，： | 1 |
| 19 | Clinical prognostic value of CD4 + CD25 + FOXP3 + regulatory T ceils in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients 显示文摘 | Li F Guo Z Lizee G | 2014 | Clin Chem Lab Med2014，59，9： | 1 |
| 20 | Real-time quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression 显示文摘 | Lizee G Aerts JL Gonzales MI | 2003 | Hum Gene Ther2003，14，6： | 1 |
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