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| 1 | 姿态稳定性的定量研究显示文摘应用ST-939人体重心平衡仪对我院职工健康体验的780名进行立位平衡功能测试,重点分析三项参数:外圆面积、轨迹长度,平均速度,结果显示:(1)21-50岁年龄范围内姿态稳定性最佳、其外圆面积小,轨迹短.速度慢.70岁以上年龄组姿态控制力下降。各项参数值较大(P<0.01).(2)视觉影响姿态稳定性.各年龄组三参数闭眼值均大于睁眼(P>001)。(3)性别对姿态控制无明显关系(P>0.05)。 | 李素芳 姜智平 李兵 吕孟新 黄江菊 周建荣0 to 50 years old was better than that of the others.Observing the people of over 70 years old The stabil | 1998 | 重庆医科大学学报1998，23，3： | 29 |
| 2 | Spontaneous bacterial peritonitis:A severe complication of liver cirrhosis显示文摘This report presents a survey of current knowledge concerning one of the relatively frequent and severe complications of liver cirrhosis and associated ascites-spontaneous bacterial peritonitis. Epidemiology,aetiology,pathogenesis,clinical manifestation,diagnosis and present possibilities of treatment are discussed. | Jan Lata Oldich Stiburek Marcela Kopacova | 2009 | World Journal of Gastroenterology2009，15，44： | 12 |
| 3 | Dynamic tracking of stem cells in an acute liver failure model显示文摘AIM:To investigate a dual labeling technique,which would enable real-time monitoring of transplanted embryonic stem cell(ESC) kinetics,as well as long-term tracking.METHODS:Liver damage was induced in C57/BL6 male mice(n = 40) by acetaminophen(APAP) 300 mg/kg administered intraperitoneally.Green fluorescence protein(GFP) positive C57/BL6 mouse ESCs were stained with the near-infrared fluorescent lipophilic tracer 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide(DiR) immediately before transplantationinto the spleen.Each of the animals in the cell therapy group(n = 20) received 5 × 10 6 ESCs 4 h following treatment with APAP.The control group(n = 20) received the vehicle only.The distribution and dynamics of the cells were monitored in real-time with the IVIS Lumina-2 at 30 min post transplantation,then at 3,12,24,48 and 72 h,and after one and 2 wk.Immunohistochemical examination of liver tissue was used to identify expression of GFP and albumin.Plasma alanine aminotransferase(ALT) was measured as an indication of liver damage.RESULTS:DiR-stained ESCs were easily tracked with the IVIS using the indocyanine green filter due to its high background passband with minimal background autofluorescence.The transplanted cells were confined inside the spleen at 30 min post-transplantation,gradually moved into the splenic vein,and were detectable in parts of the liver at the 3 h time-point.Within 24 h of transplantation,homing of almost 90% of cells was confirmed in the liver.On day three,however,the DiR signal started to fade out,and ex vivo IVIS imaging of different organs allowed signal detection at time-points when the signal could not be detected by in vivo imaging,and confirmed that the highest photon emission was in the liver(P < 0.0001).At 2 wk,the DiRsignal was no longer detectable in vivo ;however,immunohistochemistry analysis of constitutively-expressed GFP was used to provide an insight into the distribution of the cells.GFP +ve cells were detected in tissue sections resembling hepatocytes and were dispersed throughout the hepatic parenchyma,with the presence of a larger number of GFP +ve cells incorporated within the sinusoidal endothelial lining.Very faint albumin expression was detected in the transplanted GFP +ve cells at 72 h;however at 2 wk,few cells that were positive for GFP were also strongly positive for albumin.There was a significant improvement in serum levels of ALT,albumin and bilirubin in both groups at 2 wk when compared with the 72 h time-point.In the cell therapy group,serum ALT was significantly(P = 0.016) lower and albumin(P = 0.009) was significantly higher when compared with the control group at the 2 wk time-point;however there was no difference in mortality between the two groups.CONCLUSION:Dual labeling is an easy to use and cheap method for longitudinal monitoring of distribution,survival and engraftment of transplanted cells,and could be used for cell therapy models. | Tarek Ezzat Dipok Kumar Dhar Massimo Malago Steven WM Olde Damink | 2012 | World Journal of Gastroenterology2012，18，6： | 12 |
| 4 | 关于京津两城市采用 20kV 配电电压的可行性探讨显示文摘回顾京津两大城市配电网升压为10kV和高压城网深入市区的历程,总结其可资借鉴的宝贵经验。分析京津两大城市配电网用电负荷现状、规划水平和配电网网架现状,根据预测和今后发展需要,指出了提高城网电压等级并深入市区的必然趋势和采用20kV配电电压的必然性,提出了实施过渡原则和技术措施。 | Association of Old Technicians of North China Power Group Beijing, 100053 China | 1998 | 电网技术1998，22，11： | 9 |
| 5 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 6 | Biogeochemical cycles of selenium in Antarctic water显示文摘BiogeochemicalcyclesofseleniuminAntarcticwater￥XiaWeiping(DepartmentofOceanography,OldDominionUniversity,Norfolk,VA23529,USA)... | Xia Weiping (Department of Oceanography, Old Dominion University, Norfolk,VA 23529,USA)Zhang Haishen (Second Institute of Oceanography,SOA,Hangzhou 310012,China)Tan Jianan (Institute of Geography,Chinese Academy of Sciences,Beijing 100101,China) | 1996 | Journal of Environmental Sciences1996，8，1： | 6 |
| 7 | 多种癌-睾丸抗原基因在术前化疗非小细胞肺癌中的表达显示文摘目的 研究癌 睾丸抗原 (CT)抗原在经术前化疗的非小细胞肺癌 (NSCLC)中的表达谱 ,以确定NSCLC经化疗、手术后可能的辅助免疫治疗疫苗治疗组成成分。方法 用逆转录 聚合酶链反应 (RT PCR)检测了 5 1例经化疗后手术的原发性NSCLC病人肿瘤组织中 11种CT抗原基因的表达情况。结果 所检测的 11种CT基因在经化疗后的NSCLC表达最高的为MAGE 3,38% ,其次分别为NY ESO 12 1% ,CT10 17% ,LAGE 115 % ,MAGE 4 13% ,SCP 1、SSX1、SSX4均为 12 % ,MAGE 110 % ,SSX2 6 % ,CT72 %。在这些病人中 ,有 34例 (6 7% )病人表达至少 1种CT基因。在不表达所检测的任何CT基因的 17例病人中 ,13例 (76 % )为Ⅰ期病人。MAGE 3和CT10在NSCLC中表现出了随疾病进展而增加的现象 ;反之 ,SCP 1的表达主要在Ⅰ期和Ⅱ期。将NSCLC经病理分类分为鳞癌和腺癌 ,发现鳞癌中至少表达 1种CT基因 (75 % )和共表达CT基因的频率 (5 5 % )均比腺癌 (5 3%和 2 4 % )高。结论 (1)包括MAGE 3、NY ESO 1、LAGE 1等抗原成分的CT抗原疫苗可应用于术前化疗的NSCLC病人的治疗 ;(2 )对不同NSCLC肿瘤分期的病人可采取不同CT抗原成分疫苗 ;(3)对晚期手术和化疗疗效不好的病人和鳞癌病人 ,CT抗原疫苗治疗是一个值得研究的重要方向。 | 王歈 梁震 袁艳华 韩燕 刘月香 刘年 Yao-Tseng Chen Gerd Ritter Lloyd J Old 张力建 | 2004 | 中华医学杂志2004，84，6： | 4 |
| 8 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 9 | 不断发展的饲料能量价值评定显示文摘无论饲料评定体系的复杂程度如何,每种体系都能在开发它们的基础数据集上良好地运转。 | 万建美 孙相俞 Carl Old | 2011 | 国外畜牧学(猪与禽)2011，，2： | 3 |
| 10 | The Three Es of Cancer Immunoediting显示文摘 | Gavin P. Dunn Lloyd J. Old Robert D. Schreiber | 2004 | Annual Review of Immunology2004，，： | 3 |
| 11 | Interactions of pyrogallol red with proteins and the determination of proteins by resonance light-scattering | Hu Xiaoli, female, 35 years old, instructor. * Supported by the National Natural Science Foundation of China (NSFC) and the Municipal Science Foundation of Chongqing for Young and Middle Scientists (No: 97-4729). Hu Xiaoli, Feng Ping, Li Yua | 1998 | 西南师范大学学报(自然科学版)1998，23，5： | 3 |
| 12 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 13 | Postoperative deep shoulder infections following rotator cuff repair显示文摘Rotator cuff repair(RCR) is one of the most commonly performed surgical procedures in orthopaedic surgery. The reported incidence of deep soft-tissue infections after RCR ranges between 0.3% and 1.9%. Deep shoulder infection after RCR appears uncommon, but the actual incidence may be higher as many cases may go unreported. Clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. Generalized fatigue and signs of sepsis may be present in severe cases. Varying clinical presentation coupled with a low index of suspicion may result in delayed diagnosis. Laboratory findings include high erythrocyte sedimentation rate and C-reactive protein level, and, rarely, abnormal peripheral blood leucocyte count. Aspiration of glenohumeral joint synovial fluid with analysis of cell count, gram staining and culture should be performed in all patients suspected with deep shoulder infection after RCR. The most commonly isolated pathogens are Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. Management of a deep soft-tissue infection of the shoulder after RCR involves surgical debridement with lavage and long-term intravenous antibiotic treatment based on the pathogen identified. Although deep shoulder infection after RCR is usually successfully treated, complications of this condition can be devastating. Prolonged course of intravenous antibiotic treatment, extensive soft-tissue destruction and adhesions may result in substantially diminished functional outcomes. | Kivanc Atesok Peter MacDonald Jeff Leiter Sheila McRae Greg Stranges Jason Old | 2017 | World Journal of Orthopedics2017，8，8： | 3 |
| 14 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 15 | Tumor necrosis factor显示文摘 | Old L | 1985 | Science1985，230，： | 2 |
| 16 | 用中子球测量重离子碰撞中单举中子多重性显示文摘本文介绍用中子球探测器测量重离子核反应中的单举中子多重性分布.给出在27、35、44和77MeV/u四个轰击能量下^(40)Ar+^(197)Au,^(40)Ar+^(232)Th两个反应体系的实验结果.单举中子多重性分布反映了在反应过程中不同耗散程度的碰撞的相对贡献. | D.Guerreau 江栋兴 J.Galin H.Doubre J.Pouthas M.Morjean J.Fréchaut J.L.Charvet Y.Patin B.Lott Y.Pranal C.Ma■na■o J.L.Uzureau U.Jahnke G.In■old D.Jacqet | 1990 | 高能物理与核物理1990，14，6： | 2 |
| 17 | The gut-liver axis显示文摘 | Ruben G.J. Visschers Misha D. Luyer Frank G. Schaap Steven W.M. Olde Damink Peter B. Soeters | 2013 | Current Opinion in Clinical Nutrition and Metabolic Care2013，，5： | 2 |
| 18 | Impact of drying and re-wetting on N, P and K dynamics in a wetland soil显示文摘 | H. Olde Venterink T.E. Davidsson K. Kiehl L. Leonardson | 2002 | Plant and Soil2002，，1： | 2 |
| 19 | Deep learning for visualization and novelty detection in large X-ray diffraction datasets显示文摘We apply variational autoencoders(VAE)to X-ray diffraction(XRD)data analysis on both simulated and experimental thin-film data.We show that crystal structure representations learned by a VAE reveal latent information,such as the structural similarity of textured diffraction patterns.While other artificial intelligence(AI)agents are effective at classifying XRD data into known phases,a similarly conditioned VAE is uniquely effective at knowing what it doesn’t know:it can rapidly identify data outside the distribution it was trained on,such as novel phases and mixtures.These capabilities demonstrate that a VAE is a valuable AI agent for aiding materials discovery and understanding XRD measurements both‘on-the-fly’and during post hoc analysis. | Lars Banko Phillip M.Maffettone Dennis Naujoks Daniel Olds Alfred Ludwig | 2021 | npj Computational Materials2021，，1： | 2 |
| 20 | 世界家庭医生组织(WONCA)研究论文摘要汇编——帕金森病患者对诊断流程不满意度影响因素的横断面调查研究显示文摘背景帕金森病(PD)的诊断流程通常比较复杂。诊断流程可以影响到患者的自信、就医满意度以及对医务人员的信任情况。尽管诊断结果对患者造成的影响与医务人员无关,但是医务人员可以影响患者在诊断流程中的感受。本研究旨在调查PD患者对诊断流程的不满意度并探究相关影响因素。方法本项横断面研究在902例来自于荷兰帕金森病协会的PD患者中开展。每例患者均被要求书写其诊断流程。采用自行设计的赋值表对数据进行整理。各整理者之间的误差情况采用Cohen's kappa系数进行评价。使用χ~2检验和多因素Logistic回归分析评估患者对诊断流程的不满意度与性别、文化程度、诊断流程时长、患者与全科医生及神经科医生的沟通情况、参与诊断医务人员人数、是否存在二次诊断(包括提出进行二次诊断者)以及延迟诊断(患者认为有人导致了其延迟诊断也考虑在内)之间的关系。采用亚组分析探究不同性别患者对诊断流程不满意度之间的差异。结果 16.4%的PD患者明确表示对诊断流程不满意,4.8%的患者表示对诊断流程很满意。各整理者之间的误差情况Cohen's kappa系数为0.82。患者文化程度较低、参与诊断医务人员超过必要人数1人以上、患者提出进行二次诊断以及由医务人员原因导致的延迟诊断是PD患者对诊断流程不满意的危险因素。当只有全科医生与神经科医生参与诊断时,女性患者对诊断流程的不满意程度超过男性患者。结论 PD患者对诊断流程的不满意度与较低文化程度、患者提出进行二次诊断以及延迟诊断相关。了解这些因素后,如全科医生特别注意与患者进行沟通并且与患者一起进行临床决策,可以减少患者在诊断流程中的不良感受。此举有利于增加患者对医生的信任度,而患者对医生的信任度在以后的治疗过程中极其重要。 | PLOUVIER A O A OLDE HARTMAN T C DE BONT O A 本刊编辑部 | 2017 | 中国全科医学2017，20，29： | 2 |
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