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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization显示文摘血管肉瘤是有差的预后的肝的一个稀罕的主要的恶意的瘤。这里,我们与被紧急情况对待的一个破裂的肝的血管肉瘤报导一个病人的一个案例指导导管的 embolization,由左边的偏身出汗列在后面。 | Christine Leowardi Yura Hormann UIf Hinz Moritz N Wente Peter Hallscheidt Christa Flechtenmacher Markus W Büchler Helmut Friess Matthias HM Schwarzbach | 2006 | World Journal of Gastroenterology2006，12，5： | 4 |
| 3 | Surgical approaches for resection of pancreatic cancer: an overview显示文摘Objective: To overview the different surgical approach-es for the resection of pancreatic cancer and our expe-rience with these techniques.Methods: Surgical procedures including the Whipple re-section, pylorus-preserving resection, total and subto-tal panreatectomies, regional pancreatectomy and theextended lymph node resection were discussed.Results: Studies have shown that no operation seems toproduce significantly improved results in terms of sur-vival, mortality and resection rates compared to thestandard Whipple resection and pylorus-preservingduodenopancreatectomy.Conclusion: Despite the progress in the surgical treat-ment of pancreatic cancer, the overall prognosis afterresection remains unsatisfied. Surgery is likely to beoptional for the treatment of pancreatic cancer. | Helmut Friess Jrg Kleeff Markus W Buchler | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 3 |
| 4 | 胰腺癌细胞株对氟尿嘧啶存在固有不敏感性显示文摘目的 研究胰腺癌细胞株是否对氟尿嘧啶 ( 5 - FU )具有固有或获得性不敏感。方法 用 SRB方法检测5 - FU对胰腺癌细胞株 As PC- 1、Capan- 1、Mia- Pa Ca- 2、Panc- 1和 T3 M4的毒性作用。结果 5 - FU对所有胰腺癌细胞株的 IC50 都很高 ,其中 Mia- Pa Ca- 2和 Panc- 1细胞株对 5 - FU最不敏感 ( IC50 =12 ,13 nmol/ L )。即使是在 5 - FU最敏感的 Capan- 1细胞株 ,其 IC50 仍相当高 ( 473 pm ol/ L)。这些细胞株对 5 - FU的 IC50 甚至高出其临床常用剂量给药时血浆药物浓度的 1~ 5 6倍。结论 大多数胰腺癌细胞株对 5 - FU固有不敏感 ,这些发现也许能作为临床上 5 - | 刘胜利 Helmut Friess Jorg Kleeff Markus W Bchler | 2002 | 中国药科大学学报2002，33，6： | 3 |
| 5 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 6 | Duodenum preserving head resection in chronic pancreatitis changes the natural course of the disease:a single-center 26-year experience显示文摘 | Beger HG Schlosser W Friess HM | 1999 | Ann Surg1999，230，4： | 1 |
| 7 | Duodenum-preserving head resection in chronic pancreatitis changes the natural course of t hd disease:a single-center 26-year experience 显示文摘 | Beger HG Schlosser W Friess HM | 1999 | Ann Surg1999，230，： | 1 |
| 8 | Evaluation of the nano spray dryer B-90 for pharmaceutical applications 显示文摘 | Schmid K Arpagaus C Friess W | 2011 | PharmDev Technol2011，16，4： | 1 |
| 9 | Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers 显示文摘 | Witting M Obst K Friess W | 2015 | Biotechnol Adv2015，33，6： | 1 |
| 10 | Collagen - biomaterial for drug delivery显示文摘 | Friess W | 1998 | European Journal of Pharmaceutics and Biopharmaceutics1998，45，： | 1 |
| 11 | The role of infection in acute pancreatitis显示文摘 | Schmid SW Uhl W Friess H | 1999 | Gut1999，45，： | 1 |
| 12 | Wall insulation measures for residential villas in Dubai: A case study in energy efficiency显示文摘 | Friess W A Rakhshan K Hendawi T A | 2012 | Energy and Buildings2012，44，： | 1 |
| 13 | Collagen-biomaterial for drug de- livery显示文摘 | Friess W | 1998 | European Journal of Pharmaceu- tics and Biopharmaceutics1998，45，2： | 1 |
| 14 | Octreotide in the treatment of acute pancreatitis:wsults of a unicenter prespective trial with three different octreotide dosages显示文摘 | BINDER M UHL W FRIESS H | 1994 | Digestion1994，55，1： | 1 |
| 15 | Collagen sponges for bone regeneration with rhBMP-2显示文摘 | M Geiger R.H Li W Friess | 2003 | Advanced Drug Delivery Reviews2003，，12： | 1 |
| 16 | Enhanced glypican 3 expression differentiates the majority of bepatoeellular carcinomas from benign hepatic disorders显示文摘 | Zhu Z W Friess H Wang L Abou Shady M Zimmermann A Lander A D | 2001 | Gut2001，48，： | 1 |
| 17 | Collagen sponges for bone regeneration with rhBMP-2显示文摘 | Geiger M Li RH Friess W | 2003 | Adv Drug Deliv Rev2003，55，12： | 1 |
| 18 | The morphology of silicon carbide in C/C-SiC composites显示文摘 | SCHULTE-FISCHEDICK J ZERN A MAYER J RUHLE M FRIESS M KRENKEL W KOCHENDORFER R | 2002 | Mater Sci EngA2002，332，12： | 1 |
| 19 | A modified technique of the Beger and Frey procedure in patients with chronic pancreatifis 显示文摘 | Gloor B Friess H Uhl W | 2001 | Dig Surg2001，18，1： | 1 |
| 20 | Growth inhibition of Staphylococcus aureus induced by low-frequency electric and electromagnetic fields显示文摘 | OBERMEIER A MATL FLORIAN D FRIESS W | 2009 | Bioelectromagnetics2009，30，4： | 1 |
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