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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease显示文摘AIM: To investigate the diagnostic utility of beta 2 microglobulin(B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease(IBD).METHODS: Overall, 78 IBD patients and 30 healthy controls were enrolled in the study. We examined B2-M serum levels in 43 ulcerative colitis(UC) patients, 35 with Crohn's disease(CD) and 30 control subjects, using an enzymatic method. Patients were divided into two groups according to two disease types: active and in remission. Subjects were also divided into two subgroups according to extent of the disease: left-side and pancolitis for UC and ileitis and ileocolitis for CD. All groups were compared for mean serum B2-M levels and also examined to see whether there was a correlation between serum B2-M levels and other inflammatory markers.RESULTS: The mean serum B2-M levels in the control group, UC and CD were 1.71, 2.41 and 2.24 respectively. B2-M values ≥ 1.96 mg/L had a 62% sensitivity, 76% specificity, a 79% positive predictive value, and a 58% negative predictive value for UC patients. B2-Mvalues ≥ 1.70 mg/L had 80% sensitivity, 53% specificity, 66% positive predictive value, and 69% negative predictive value for CD patients. Mean B2-M values were significantly higher in ulcerative colitis and Crohn's disease patients than in healthy controls(UC 2.41 ± 0.87 vs 1.71 ± 0.44, P = 0.002; CD 2.24 ± 1.01 vs 1.71 ± 0.44, P = 0.033). Also, mean B2-M values were significantly higher in active disease when compared to patients in remission(UC 2.66 ± 0.92 vs 1.88 ± 0.41, P = 0.004; CD 2.50 ± 1.15 vs 1.73 ± 0.31, P = 0.033). The difference between groups(UC and CD) in terms of serum B2-M levels was statistically insignificant(2.41 ± 0.87 vs 2.24 ± 1.01, P > 0.05 respectively).CONCLUSION: Serum B2-M levels may be used as an activity parameter in IBD. | Bülent Y|lmaz Seyfettin Kklü Osman Yüksel Serap Arslan | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 3 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 2 |
| 4 | Productivity growth in OECD countries: A comparison with Malmquist indices显示文摘 | Bar?? K. Y?rük Osman Zaim | 2005 | Journal of Comparative Economics2005，，2： | 2 |
| 5 | Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases显示文摘 | Cumali Efe Staffan Wahlin Ersan Ozaslan Alexandra Heurgue Berlot Tugrul Purnak Luigi Muratori Chiara Quarneti Osman Yüksel Gérard Thiéfin Paolo Muratori | 2012 | European Journal of Gastroenterology & Hepatology2012，，5： | 2 |
| 6 | The comparison of pul- monary functions in open versus laparoscopic cholecystee- tomy显示文摘 | Osman Y Fusun A Serpil A | 2009 | J Pak Med Assoc2009，59，4： | 1 |
| 7 | Seroprevalence of antibodies to human herpesviruses in England and Hong Kong显示文摘 | Kangro H O Osman H K Lau Y L | 1994 | J Med Virol1994，43，1： | 1 |
| 8 | A class of proportional in tegral sliding mode control with application to active suspension system显示文摘 | Sam Y M Osman H S Ghani M R | 2004 | Systems & Control Letters2004，51，3： | 1 |
| 9 | Anterior and posterior nutcracker syndrome:a report on 11 cases显示文摘 | Dein B Osman Y Shohab AB | 2003 | Transplant Proc2003，35，2： | 1 |
| 10 | 在有非酒精的 steatohepatitis 的病人的增加的骨头矿物质密度显示文摘 AIM:To determine the relationship between non-alcoholic steatohepatitis(NASH)and bone mineral density(BMD).METHODS:A total of 38 patients(25 males)with a diagnosis of histologically proven NASH and 42 healthy controls(24 males)were enrolled in the study.Demographic features,clinical findings,complete blood count and routine biochemical analysis,as well as adrenal,thyroid and gonadal functions,were recorded.Additionally,intact parathormone,25-OH-vitamin-D3,tumor necrosis factor-α,interleukin-6,interleukin-1,in-sulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels were measured in both groups.Furthermore,lumbar spine and femoral neck BMD of both groups were measured by the dual-energy X-ray absorptiometry(DXA)method.RESULTS:The mean age was 41±12 years in the NASH group and 43±11 years in the control group.Among demographic features,waist circumference was significantly larger in the NASH group compared to the control group(P<0.019).Among laboratory parameters,serum triglyceride(P<0.008),alanine transaminase(P<0.0001),aspartate transaminase(P<0.001),alkaline phosphatase(P<0.016),gamma glutamyl transferase(P<0.0001),ferritin(P<0.001)and 25-OH-vitamin-D3levels(P<0.0001)were significantly higher in the NASH group compared to the control group.Lumbar BMD was significantly higher in the NASH group compared to the control group(1.057±0.119 g/cm2vs 0.941±0.133 g/cm2;P<0.001,respectively).In the NASH group,there was no significant relationship between BMD and fibrosis stage in liver biopsy.CONCLUSION:NASH increases BMD and may be related to an elevated serum 25-OH-vitamin D3 level. | Muhsin Kaya Devran Isik Remzi Bestas Osman Evliyaoglu Veysi Akpolat Hüseyin Büyükbayram Mehmet Ali Kaplan | 2013 | World Journal of Hepatology2013，5，11： | 1 |
| 11 | U rinary complication of migrated intrauterine contracep- tive device显示文摘 | El-Hefnawy A S EI-Nahas A R Osman Y | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，2： | 1 |
| 12 | Anterior and posterior nutcracker syndrome:a report on 11 case显示文摘 | Ali-El-Dein B Osman Y Shehab EL-Din AB | 2003 | Transplant Proc2003，35，2： | 1 |
| 13 | The value of frozen-section analysis of ureteric margins on surgical decisionmaking in patients undergoing radical cystectomy for bladder cancer显示文摘 | OSMAN Y EL-TABEY N ABDEL-LATIF M | | 0，，01： | 1 |
| 14 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 1 |
| 15 | Left-Sided Portal Hypertension显示文摘 | Seyfettin K?klü ?ahin ?oban Osman Yüksel Mehmet Arhan | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 16 | Ruminant Brucellosis in the Kafr El Sheikh Governorate of the Nile Delta, Egypt: Prevalence of a Neglected Zoonosis显示文摘 | Hegazy Y M Moawad A Osman S | 2011 | Plos neglected tropical diseases2011，5，1： | 1 |
| 17 | Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos显示文摘 | Bao J Lin H Ouyang Y Lei D Osman A Kim TW Mei L Dai P Ohlemiler KK Ambron RT | | 0，，： | 1 |
| 18 | Noninvasive manage- ment of hemangioma and vascular malformation using intralesional bleomycin injection 显示文摘 | HASSAN Y OSMAN A K AHYEB A | 2013 | Ann Plast Surg2013，70，1： | 1 |
| 19 | The laccase/ABTS system oxidizes ( + ) catechin to oligomeric products 显示文摘 | Osman A M Wong K K Y Fernyhough A | 2007 | Enzyme Microb Technol2007，40，5： | 1 |
| 20 | Report of 24 Left-Sided Portal Hypertension Cases: A Single-Center Prospective Cohort Study显示文摘 | Seyfettin K?klü MD Osman Yüksel MD Mehmet Arhan MD ?ahin ?oban MD ?mer Ba?ar MD ?mer Faruk Yolcu MD Engin U?ar MD Mehmet Ibi? MD ?brahim Ertu?rul MD Burhan ?ahin MD | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
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