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| 1 | 稻株上拮抗细菌的定殖及其对土著细菌的影响显示文摘在温室条件下,通过分批播种、接种纹枯病菌Rhizoctonia solani,以及在水稻分孽盛期喷雾拮抗细菌Pseudomonas fluorescensPf7—14(天然的抗萘啶酮酸菌株)和B5423.R(Bacillus subtilisB5423的利福平抗性突变体)的菌悬浮液,并通过定期取样,平板系列稀释法回收,测定了菌株Pf7-14、135423-R和土著细菌群体在水稻健株和纹枯病株上的种群数量,所获结果如下:①当相同的浓度(约2.0×10^8cfu/m1)的菌悬浮液喷雾到叶片时,菌株Pf7—14定殖的时间比菌株B5423-R长,且在相同的时间内,菌株Pf7—14的平均群体数量高于菌株B5423-R;②在健康的水稻茎部,菌株Pf7—14的两个高、低不同浓度处理的平均群体数量均表现出随时间降低的趋势;相比,较低浓度(4.0×10^7cfu/m1)的B5423-R在茎部的平均群体数量随着时间的下降,而较高浓度(2.0×10^8cfu/m1)的B5423-R的平均群体数量在水稻乳熟至黄熟期保持稳定或略有增长;③当病斑面积占取样茎面积的比率为20%~35%时,在应用1和14d后菌株PU-14在健茎的平均群体数量分别是病茎的6倍多和2倍多,差异均达到显著性的水平(P=0.05),而菌株B5423.R在应用1d后病茎的数量比在健茎显著性地低大约1倍,但在7~14d后,病茎的数量比在健茎显著性地高5~6倍,群体在病茎表现出相对的增长;④土著细菌群体在病斑茎部是健茎的6~7倍。这些结果表明两类拮抗细菌有着明显不同的定殖习性,在病斑上B5423比pf/-14具有更强的竞争能力,是一类更好的生防制剂;同时表明引入的拮抗细菌同土著细菌群体在营养和空间上竞争激烈,且土著细菌群体更具有竞争优势。 | 李湘民 许志刚 MEW TW | 2008 | 生态学报2008,28,8: | 17 |
| 2 | ASPECCT研究:帕尼单抗的疗效与西妥昔单抗相当显示文摘本研究中,参加试验的患者(来自北美,南美,欧洲,亚洲,非洲和澳大利亚治疗中心)年龄均在18岁以上,均为化疗难治性转移性结直肠癌,ECOG评分在2分或以下,KRAS外显子2的状态为野生型。使用计算机生成的随机序列,研究人员以1:1分配患者(按地理区域和ECOG评分进行分层)接受帕尼单抗(6 mg/kg,每2周一次)或西妥昔单抗(初始剂量为400 mg/m2,之后250 mg/m2,每周一次)治疗。 | Price TJ Peeters M Kim TW | 2014 | 中华结直肠疾病电子杂志2014,3,2: | 16 |
| 3 | 肝素使用和监控指南显示文摘肝素是天然氨基葡聚糖,由肥大细胞产生。药用的肝素由猪或牛的黏膜中提取。肝素由糖醛酸链和葡糖胺链交替组成,含多少不等的硫酸根,相对分子质量5ku-35ku。现在使用的制剂平均相时分子质量(MW)为13ku~15ku,比活性180—220u/mg。 | Baglin T Barrowcliffe TW Coben A Greaves M 陈君敏 曾开淇 | 2006 | 血栓与止血学2006,12,1: | 13 |
| 4 | 利用深度卷积神经网络分析超声图像进行肝纤维化自动分类显示文摘无创评估肝纤维化进程是目前临床研究的热点。瞬时弹性成像、剪切波弹性成像和磁共振(MRI)弹性成像得到越来越多的应用。针对CT和MRI图像的深度卷积神经网络(DCNN)评估肝纤维化显示出较高的诊断效能,而针对B型超声图像进行深度学习的报道较少。该研究通过建立深度卷积神经网络对B型超声图像预测肝纤维化METAVIR评分。收集两个专科院校转诊中心的3446例患者的13608张超声图像用于训练DCNN,患者接受手术切除、肝穿刺活检或瞬时弹性成像检查,以病理标本或瞬时弹性成像得出估计的METAVIR分数用作参考标准,建立四分类模型(F0比F1比F23比F4)。 | Lee JH Joo I Kang TW 薛立云(编译) | 2020 | 中华医学杂志2020,100,39: | 11 |
| 5 | 砷、氟对大鼠骨组织联合作用的实验研究显示文摘本研究应用现代质子微探针技术及定量组织学方法,探讨了砷、氟在牙齿与骨骼不同组织中的分布和作用。结果揭示:(1)氟(100mg/L)引起大鼠切牙与人类相似的氟斑牙;(2)砷(30mg/L)不沉积于骨组织中,未见砷对骨组织有损害作用;(3)砷与氟在对机体增长的抑制上呈协同作用;(4)砷与氟在对骨组织作用上无明显联合作用;砷不影响氟对骨组织的作用;(5)砷不能显著地拮抗氟在骨组织中的沉积。 | 李达圣 TW Cutress EIF Pearce GE Coote | 1996 | 中国地方病防治1996,11,3: | 10 |
| 6 | 浅谈根管治疗的成功与失败显示文摘 | Rich.,TW | 1991 | 中华口腔医学杂志1991,26,3: | 9 |
| 7 | 砷对大鼠氟牙症影响的实验研究显示文摘为探讨砷对氟中毒的影响及砷氟间的联合作用,本研究将砷(30mg/L)和氟(100mg/L)经饮水投与大鼠10周,应用质子微探针技术及定量组织学方法,观察了砷、氟在牙齿中的分布和作用。结果揭示:①氟引起大鼠切牙与人类相似的氟牙症,本研究应用氟牙症分级标准评价了大鼠氟牙症特征;②砷不沉积于牙硬组织中,未见砷对牙齿有损害作用;③砷与氟在对牙组织作用上无明显联合作用,砷不影响氟对牙组织的毒性作用; | 李达圣 TW Cutress 李晓松 GE Coote | 1996 | 中华预防医学杂志1996,30,6: | 8 |
| 8 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015,21,1: | 6 |
| 9 | Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.显示文摘 | Oblinger JL Pearl DK Boardman CL Saqr H Prior TW Scheithauer BW Jenkins RB Burger PC Yates AJ | 2006 | 中国神经肿瘤杂志2006,4,2: | 5 |
| 10 | Chemopreventive effect of oltipraz on AFB_1-induced hepatocarcinogenesis in tree shrew model显示文摘INTRODUCTIONHepatocellular carcinoma (HCC) is one of themajor cancers in the world with a mortality of morethan 250 000 cases yearly.More than 137 000 casesof HCC were diagnosed each year in China,whichacount approximately for more than 40 percent ofthe total number in the world.HCC has become thesecond major cause of death for cancer in | TW Kensler BD Roebuck | 2000 | World Journal of Gastroenterology2000,6,5: | 5 |
| 11 | 持续性疼痛中“应对反应”行为相关通路的确定显示文摘动物和人类对伤害刺激表现出两种类型的反应,一种是'反射性防御反应(reflexive defensive re-sponses)',另一种是'应对反应(coping responses)';然而,产生这两种行为的神经通路却仍然不清楚.在该研究中,研究人员通过基因消融、电生理、逆行标记、免疫染色、行为学测试等手段对小鼠两种行为反应神经通路进行了研究.结果表明:TAC1Cre和LBX1Flpo在脊髓共表达的神经元是疼痛相关反应所必需的,此类神经元的消融会导致引起持续性疼痛刺激(包括皮肤捏伤和烧伤)所诱发的'应对反应'行为丧失,但不影响任何'反射性防御反应'.该研究揭示了皮肤体感系统中与'应对反应'相关的一个基本通路,并首次尝试使用'反射防御反应'来测量持续性疼痛的有效性,为疼痛医学的创新发展提供了新的依据和思路. | Huang TW 陈丹 | 2019 | 中国疼痛医学杂志2019,25,7: | 4 |
| 12 | Bioinformatics advances in saliva diagnostics显示文摘There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic,translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval,integration and analysis of data,we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart. | Barry Smith David TW Wong | 2012 | International Journal of Oral Science2012,4,2: | 3 |
| 13 | 髁突切除术治疗下颌骨活动性单侧髁突增生和严重面部不对称:18年回顾性研究显示文摘Kim JY,Ha TW,Park JH,et al.Condylectomy as the treatment for active unilateral condylar hyperplasia of the mandible and severe facial asymmetry:retrospective review over 18 years.Int J Oral Maxillofac Surg,2019 Jun.下颌骨单侧髁突增生(UCH)是一种影响髁突大小的疾病,导致面部不对称。本研究回顾性分析2000-2017年在延世大学口腔医院接受髁突切除术的27例UCH患者,总结了患者的人口统计学特征。UCH分为3种亚型:半侧下颌骨延长(HE,n=15)、半侧下颌骨增生(HH,n=4)和骨软骨瘤(OC,n=8)。在27例患者中,只有1例为HE型,5例患者(18.5%)伴有关节疼痛。所有患者的骨扫描显示UCH侧的摄取较高。 | 赵泽亮 Kim JY Ha TW Park JH | 2019 | 中国口腔颌面外科杂志2019,17,5: | 3 |
| 14 | 少量无机硝酸盐或甜菜根可有效抑制盐诱发的血压升高显示文摘为降低盐诱发高血压的风险,医学专家强调的膳食指南是促进高钾低钠摄入以使钾钠摩尔比≥1∶1。然而过去几十年间,几乎没人改变他们的膳食习惯以充分满足推荐的膳食钠钾目标。因此,降低盐诱发高血压的风险又不要求改变主要膳食习惯的新策略具有相当大的医学意义。该研究在一个广泛应用的盐诱发高血压模型Dahl盐敏感性大鼠中,发现补充硝酸盐与钠的摩尔比约为1∶170时,补充膳食硝酸盐摄入可以抑制盐诱发高血压的形成。 | 赵狄 练桂丽 Morris RC Jr Pravenec M ■ J DiCarlo SE Kurtz TW | 2019 | 中华高血压杂志2019,27,6: | 3 |
| 15 | The interdisciplinary study of coordination显示文摘 | Malone TW Crowston K | 1994 | ACM Computing Surveys1994,26,1: | 2 |
| 16 | 近期呼吸道感染与心血管疾病风险间关系初探显示文摘 | Clayton TC Thompson M Meade TW 袁志敏(摘译) 刘运德(校) | 2008 | 心血管病学进展2008,29,5: | 2 |
| 17 | Management of choroidal neovascularization following laser photocoagulation for central serous chorioretinopathy 显示文摘 | Ha TW Ham DI Kang SW | 2002 | Korean J Ophthalmol2002,16,2: | 2 |
| 18 | Histopathologic features in esophagomyotomy specimens from patients with achalasia显示文摘 | JR Goldblum TW Rice JE Richter | 1996 | Gastroenterology1996,,3: | 2 |
| 19 | The effect various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay显示文摘 | Anderson D Yu TW Pillips BT | 1994 | Matation Res1994,307,: | 2 |
| 20 | Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome 显示文摘 | Lew TW Kwek TK Tai D | 2003 | JAMA2003,290,: | 2 |