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| 1 | 人类皮下和网膜脂肪组织中脂联素基因的表达和调控的研究显示文摘目标:探讨脂联素在人类皮下和网膜脂肪组织中mRNA表达水平,以及糖皮质激素和PPARγ激动剂对脂联素的调控作用。方法:应用real-time摇RT-PCR方法观察了16名成人腹部皮下和网膜脂肪组织中脂联素mRNA表达水平以及与肥胖的关系。通过体外培养,观察地塞米松(dexamethasone,DEX)和/或PPARγ激动剂(troglitazone,TGZ)对不同部位脂肪组织脂联素的表达和分泌的调控作用。结果:皮下和网膜脂肪组织脂联素mRNA表达丰富但无显著部位差异,网膜脂肪组织脂联素mRNA水平与BMI呈显著负相关(r=0.56,P<0.05)。体外培养24h后,TGZ处理组脂肪组织脂联素基因的表达明显增加(皮下:70%;网膜:102%),且网膜脂肪组织脂联素的分泌明显高于对照组(P<0.05);DEX则下调网膜脂肪组织脂联素mRNA的表达水平36%,TGZ可逆转这种抑制作用。结论:网膜脂肪组织中脂联素mRNA的表达随BMI增加而下降,并受到糖皮质激素及PPARγ激动剂调控。脂联素的部位特异性表达和调控可能是内脏型肥胖连接胰岛素抵抗的重要分子机制。 | 李晓南 陈荣华 潘亚 Tommy Olsson Olle Hernell | 2006 | 南京医科大学学报(自然科学版)2006，26，1： | 12 |
| 2 | 基于在线客户评论的客户细分研究显示文摘针对基于在线客户评论数据进行客户细分分析的问题,设计了二阶段客户细分分析框架。在客户偏好建模阶段,设计了同义属性识别方法和属性偏好换算方法,基于产品属性树结构,构建粒度统一的客户偏好向量;在客户聚类阶段,设计了包含最优聚类数识别的聚类流程,基于模糊C均值聚类方法,对客户进行聚类。 | 蔡淑琴 蒋士淼 G D OLLE OLLE 秦志勇 | 2015 | 管理学报2015，12，7： | 9 |
| 3 | 人类皮下和网膜脂肪组织脂肪细胞因子的表达显示文摘目的探讨脂肪细胞因子在成人皮下和网膜脂肪组织中的表达水平。方法应用即刻定量PCR方法测定16例成人皮下和网膜脂肪组织中瘦素、脂联素、肿瘤坏死因子α(TNF-α)和抵抗素的表达水平。结果正常体重组和超重组皮下脂肪组织瘦素mRNA水平均明显高于网膜组织(P<0.01);正常组网膜脂肪组织脂联素mRNA水平较皮下组织有升高趋势(P=0.07);TNF-α和抵抗素mRNA表达水平低下且无显著部位差异。无论皮下或网膜脂肪组织瘦素表达水平均与体重指数(BMI)成正相关(皮下:r=0.68,P<0.01;网膜:r=0.71,P<0.01)),而网膜脂肪组织脂联素表达与BMI呈明显负相关(r=-0.60,P<0.05)。结论基因编码的一些细胞因子在脂肪组织中的表达呈部位特征,肥胖时皮下和网膜脂肪组织瘦素过度表达,而内脏脂肪组织脂联素表达下调,这可能是肥胖相关的胰岛素抵抗发生的潜在危险因素。 | 李晓南 陈荣华 Tommy Olsson Olle Hernell | 2005 | 江苏医药2005，31，12： | 5 |
| 4 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 5 | 图书馆信息服务与科技论文质量的相关性研究显示文摘通过对中瑞两国医学论文引文数量、时间以及被引次数的分析,量化说明中国科技论文与发达国家相比存在的质量差距。认为中国医学论文依据的信息不足,所提供信息量少,利用信息时间滞后,从而影响到科研论文的可信度和新颖性,使论文的可利用价值低。分析形成的原因,指出图书馆信息保障能力影响着科技论文质量和创新。 | 杨春华 Olle Persson | 2005 | 图书情报工作2005，49，1： | 5 |
| 6 | 运用卫星数据和来自国家森林清查的野外数据进行全国森林变量估计显示文摘瑞典约有55%的土地面积被森林所覆盖。目前,瑞典的森林覆盖没有统一的和地理学上明晰的描述。现存的独立性数据源是Landsat TM和SPOT HRV卫星数据、地图蒙片(map mask)和森林清查样地。它们在一起,使森林变量(如材积和林分年龄)的计算机估计成为可能。这些估计的精确度在像素水平上是低的,但在林分水平上较高。在规划木材资源应如何加以利用或出于监测目的时,这类基于栅格的森林数据对政府来说是有帮助的。本文描述了以有效成本建立森林变量估计全国数据库的生成流程。我们在林分水平上评价了瑞典西南部某地森林变量估计的精确度。结果表明,总材积估计的整体均方根误差为33%,年龄估计的整体均方根误差为23%。 | Heather Reese Mats Nilsson Tina Granqvist Pahlén Olle Hagner Steve Joyce Ulf Tingelf Mikael Egberth Hkan Olsson 王胜 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 7 | 参与式管理解决冲突:遥感和GIS用作瑞典北部驯鹿业土地利用需求信息交流的工具显示文摘在解决复杂的土地管理问题时,对短缺或者有争执的资源进行地理评估有助于不同利益相关者之间沟通认识和增进理解。本文中,我们说明如何使用遥感和GIS收集和汇总瑞典北部驯鹿放牧者和其他土地使用者(林业、采矿业、旅游业等等)的土地使用活动及使用模式的信息。该项目主要基于最终的土地使用者,即驯鹿放牧者们所做的工作,体现了面向土地使用者的新的努力。发展驯鹿业的土地利用规划的基础有以下几个方面:收集并数字化传统的驯鹿栖息地生态学和景观信息;将这些信息与来自野外调查及基于人造卫星观测的植被分类结果整合;绘制其他土地使用者的活动情况图。最终的土地利用规划提供的信息有利于驯鹿放牧者与其他利益相关者之间的磋商,并有助于驯鹿管理实施。该项目可作为一种大众参与和计划编制的模式,从而使本土信息和先进的遥感技术融入一个交互式的过程中。 | Per Sandstrm Tina Granqvist Pahlén Lars Edenius Hans Tφmmervik Olle Hagner Leif Hemberg Hkan Olsson Karin Baer Thomas Stenlund Lars Gran Brandt Mikael Egberth 周立志 程利群 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 8 | 麦角硫因或可降低心血管疾病发生及死亡风险显示文摘目的近期研究发现一种健康饮食模式(HCFP)与降低心脏代谢疾病风险相关,但导致这种相关性的分子机制尚不明确。该研究旨在发现与这种饮食模式相关的血浆代谢物,并研究其与心脏代谢疾病发生和死亡风险的相关性。方法从全人群马尔默饮食和癌症研究中,筛选出3236名无心血管疾病和糖尿病史的参与者。运用液相色谱-质谱法对他们的112种血浆代谢物进行检测。通过多元线性回归和Bonfcrroni校正分析,发现其中与该饮食模式相关的代谢物。使用多变量Cox比例风险模型进行长期随访分析后,发现这些健康饮食的生物标志物与心脏代谢疾病的发生和死亡风险相关。结果平均随访21.4年期间,603人患心血管疾病,362人患糖尿病,843人死亡。基线资料中,5种健康饮食标志物与该饮食模式相关(P<0.0004),其中4种与至少一项研究终点相关(P<0.05)。麦角硫因是与该饮食模式相关性最强的代谢物,并且与降低冠心病风险(危害比0.85,P=0.01)、心血管死亡风险(危害比0.79,P=0.002)、全因死亡风险(麦角硫因每增加一个标准差的危害比,危害比0.86,P=4e-5)相关。结论我们发现高麦角硫因含量是降低心脏代谢疾病发生和死亡风险的独立标志物。而这种高含量很可能是由某种特殊的饮食方式造成的。 | Einar Smith Filip Ottosson Sophie Hellstrand Ulrika Ericson Marju Orho-Melander Celine Fernandez Olle Melander 冯博(译) | 2020 | 英国医学杂志中文版2020，23，4： | 4 |
| 9 | Validity of the visual analogue scale as an instrument to measure self‐efficacy in resuscitation skills显示文摘 | Nigel MTurner Anita JVan De Leemput Jos M TDraaisma PaulOosterveld Olle Th JTen Cate | 2008 | Medical Education2008，，5： | 4 |
| 10 | Asymmetric photocurrent extraction in semitransparent laminated flexible organic solar cells显示文摘Scalable production methods and low-cost materials with low embodied energy are key to success for organic solar cells.PEDOT(PSS)electrodes meet these criteria and allow for low-cost and all solution-processed solar cells.However,such devices are prone to shunting.In this work we introduce a roll-to-roll lamination method to construct semitransparent solar cells with a PEDOT(PSS)anode and an polyethyleneimine(PEI)modified PEDOT(PSS)cathode.We use the polymer:PCBM active layer coated on the electrodes as the lamination adhesive.Our lamination method efficiently eliminates any shunting.Extended exposure to ambient degrades the laminated devices,which manifests in a significantly reduced photocurrent extraction when the device is illuminated through the anode,despite the fact that the PEDOT(PSS)electrodes are optically equivalent.We show that degradation-induced electron traps lead to increased trap-assisted recombination at the anode side of the device.By limiting the exposure time to ambient during production,degradation is significantly reduced.We show that lamination using the active layer as the adhesive can result in device performance equal to that of conventional sequential coating. | Jonas Bergqvist Thomas Osterberg Armantas Melianas Luis Ever Aguirre Zheng Tang Wanzhu Cai Zaifei Ma Martijn Kemerink Desta Gedefaw Mats R.Andersson Olle InganAs | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 11 | Development of polymer–fullerene solar cells显示文摘Global efforts and synergetic interdisciplinary collaborations on solution-processed bulk-heterojunction polymer solar cells(PSCs or OPVs) made power conversion efficiencies over 10%possible.The rapid progress of the field is credited to the synthesis of a large number of novel polymers with specially tunable optoelectronic properties,a better control over the nano-morphology of photoactive blend layers,the introduction of various effective interfacial layers,new device architectures and a deeper understanding of device physics.We will review the pioneering materials for polymer-fullerene solar cells and trace the progress of concepts driving their development.We discuss the evolution of morphology control,interfacial layers and device structures fully exploring the potential of photoactive materials.In order to guide a further increase in power conversion efficiency of OPV,the current understanding of the process of free charge carrier generation and the origin of the photovoltage is summarized followed by a perspective on how to overcome the limitations for industrializing PSCs. | Fengling Zhang Olle Ingans Yinhua Zhou Koen Vandewal | 2016 | National Science Review2016，3，2： | 4 |
| 12 | Antimicrobial Profile of Lactic Acid Bacteria Isolated from Vegetables and Indigenous Fermented Foods of India against Clinical Pathogens Using Microdilution Method显示文摘In dairy and food industries lactic acid bacteria(LAB)have been used in form of starter culture that plays vital role in fermentation;as flavouring and texturizing or as preservative agents.There is increasing evidence that lactobacilli which inhabit the gastrointestinal tract develop antimicrobial activities and participatein the host’s defence system[1].During fermentation,most of the LAB produces a number of different compounds like organic acids,hydrogen peroxide,diacetyl,acetaldehyde,carbon dioxide,polysaccharides,and proteinaceous compounds called bacteriocins or bacteriocinogenic peptides[2-3].Such metabolites exert antimicrobial activity and | Ami PATEL Nihir SHAH Padma AMBALAM J. B. PRAJAPATI Olle HOLST Asa LJUNGH | 2013 | Biomedical and Environmental Sciences2013，26，9： | 4 |
| 13 | Similar causes of various reproductive disorders in early life显示文摘在过去几十年期间,科学证据在野生动物和人的人口的健康上有关暴露的可能的不利效果被积累了到环境化学药品。人为或自然的起源的如此的混合物的一个大、成长的组被叫作内分泌破坏的化学药品(EDC ) ,由于他们内分泌的系统上的有害行动。这颗担心首先特别地在男性集中于繁殖功能的控制,但是以后被扩展了包括所有可能的内分泌的函数。现在的评论在在 masculinization 过程和外部男生殖器的合适的 organogenesis 发生在男性和雄激素的特定的角色的性区别期间的发展事件的串联后面描述内在的生理学。基因背景,在 hypospadias 的病原学的环境暴露和生活方式因素, cryptorchidism 和阴囊的癌症的影响被考察,在这些繁殖混乱的发展的 EDC 的可能的角色极其被讨论。最后,可能直接并且编程在 utero 暴露完成广泛地在人在繁殖畸形和差的精液质量的发生上使用治疗学的混合物,环境雌激素和另外的化学药品也被加亮。 | Konstantin Svechnikov Jan-Bernd Stukenborg Iuliia Savchuck Olle Sider | 2014 | Asian Journal of Andrology2014，16，1： | 4 |
| 14 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 15 | 一种环境友好的鞣制工艺显示文摘研制一种新的鞣制工艺(亮湿革),用此工艺可以生产出一种合格的汽车内饰浅色革。此工艺是无铬、无醛、无有机溶剂挥发的绿色工艺。工艺的重点是使用了凯米拉公司提供的无毒、无害、绿色、安全的鞣剂。与传统的铬鞣革和醛鞣革相比,新工艺无论对环境或在经济上考虑都有很大的优势,具体来说,与传统的铬鞣革相比,可使废水中化学需氧量(COD)降低60%,悬浮液体降低61%,氮含量降低65%,此外这种工艺生产出的亮湿革的挥发性化合物比蓝湿革降低43%,比白湿革降低8%,更为重要的是,真正地做到了无铬废水排放。 | Anna Bacardit Stefan vander Burgh Jordi Armengol Luis Ollé 孙海云 金博 | 2014 | 皮革与化工2014，31，4： | 3 |
| 16 | 当前围手术期处理模式:北欧五国结直肠外科医生调查显示文摘 | Kristoffer Lassen Pascal Hannemann Olle Ljungqvist Ken Fearon Cornelis H C Dejong Maarten F von Meyenfeldt Jonatan Hausel Jonas Nygren Jens Andersen Arthur Revhaug 王东 | 2005 | 英国医学杂志中文版2005，8，6： | 3 |
| 17 | 从引用和被引情况看中国科技论文质量-与瑞典的比较显示文摘通过对中瑞两国医学论文引文数量和时间的比较,以及对非英语国家发表论文的被引次数、期刊影响因子及国际排名的比较,发现中国科技论文与发达国家相比,确实存在着可以量化的差距:课题研究依据的信息和论文提供的信息量少,引用信息时间滞后,从而影响到科研论文的可信度和新颖性。质量差距是我国科技论文被引率低的真正原因。 | 杨春华 OLLE PERSSON 颜世刚 李书宾 | 2003 | 中国科技论坛2003，，6： | 3 |
| 18 | Insulin Resistance and Outcomes in Surgery显示文摘 | Olle Ljungqvist | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，9： | 2 |
| 19 | Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator显示文摘Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications.In particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays.This betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial coherence.However,despite its unique features,the usability of the betatron source has been constrained by its poor control and stability.In this article,we demonstrate the reliable production of X-ray beams with tunable polarization.Using ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and controlled.We observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam divergence.The polarization ratio reaches 80%,and the polarization axis can easily be rotated.We anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications. | Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 20 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials显示文摘 | Krishna K. Varadhan Keith R. Neal Cornelius H.C. Dejong Kenneth C.H. Fearon Olle Ljungqvist Dileep N. Lobo | 2010 | Clinical Nutrition2010，，4： | 2 |
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