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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | 中国新疆维吾尔自治区不明原因发热人群中Tahyna病毒感染状况调查显示文摘本研究通过对新疆地区不明原因发热人群血清Tahyna病毒抗体进行检测,以了解Tahyna病毒在当地的感染状况及分布特征。通过间接免疫荧光方法对新疆维吾尔自治区南部喀什地区、北部伊犁地区742例不明原因发热患者急性期血清标本进行Tahyna病毒抗体检测,并对IgM抗体阳性标本平行进行Tahyna病毒、Snowshoe hare病毒和Inkoo病毒三种抗原性相似的布尼亚病毒的蚀斑减少中和试验。研究结果显示新疆南部喀什地区采集不明原因发热患者急性期血清中,IgM抗体阳性率5.3%,IgG抗体阳性率18.3%;新疆北部伊犁地区采集的急性期患者血清标本中并未发现TAHV IgM抗体阳性;蚀斑减少中和试验结果显示,TAHV IgM抗体阳性患者血清中Tahyna病毒中和抗体滴度较其它两种布尼亚病毒中和抗体滴度升高明显。本研究证实新疆南部地区不明原因发热人群存在Tahyna病毒的急性感染和既往感染,为相关疾病的进一步监测提供基础。 | 吕志 付士红 王凤田 Kosoy Olga L Nasci Roger S 梁国栋 | 2011 | 病毒学报2011，27，1： | 8 |
| 3 | Intestinal bile acid physiology and pathophysiology显示文摘Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology. | Olga Martínez-Augustin Fermín Sánchez de Medina | 2008 | World Journal of Gastroenterology2008，14，37： | 7 |
| 4 | Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy显示文摘Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction. | Vyacheslav I Egorov Roman V Petrov Michail V Lozhkin Olga A Maynovskaya Natalia S Starostina Natalia R Chernaya Ekaterina M Filippova | 2013 | World Journal of Gastrointestinal Surgery2013，5，3： | 7 |
| 5 | Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture显示文摘AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(H.pylori) isolation and diagnosis.METHODS:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy samples.Homogenized biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic environment.Additionally,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of H.pylori and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the content.Results obtained by CC,CLO test,and HE were compared with those of MC.The diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and CI.RESULTS:H.pylori was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy samples.In 25(25/26) patient biopsy samples,H.pylori was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,H.pylori was isolatedby CC.CLO test and HE were found positive in 17(17/26) patient biopsy samples.Comparing the results of the isolation of H.pylori by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for H.pylori has high diagnostic sensitivity compared with CC,HE,and CLO tests. | Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel Emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 6 | Decompression of the Portal Bed and Twice-Baseline Portal Inflow Are Necessary for the Functional Recovery of a “Small-for-Size” Graft显示文摘 | Amelia J. Hessheimer Constantino Fondevila Pilar Taurá Javier Mu?oz Olga Sánchez José Fuster Antoni Rimola Juan Carlos García-Valdecasas | 2011 | Annals of Surgery2011，，6： | 2 |
| 7 | Determination of malachite green residues in fish using molecularly imprinted solid-phase extraction followed by liquid chromatography–linear ion trap mass spectrometry显示文摘 | María Jesús Martínez Bueno Sonia Herrera Ana Uclés Ana Agüera María Dolores Hernando Olga Shimelis Marcus Rudolfsson Amadeo R. Fernández-Alba | 2010 | Analytica Chimica Acta2010，，1： | 2 |
| 8 | Anti- Helicobacter pylori activity of Terminalia macroptera root显示文摘 | Olga Silva Sílvia Viegas Cristina de Mello-Sampayo Maria Jo?o P. Costa Rita Serrano José Cabrita Elsa T. Gomes | 2012 | Fitoterapia2012，，5： | 2 |
| 9 | Induction of lymphocytes activated marker CD69 following exposure to chitosanand alginate biopolymers显示文摘 | OLGA B GERRIT B ADRIANODE S | 2007 | Int J Pharm2007，337，12： | 1 |
| 10 | Polo-like kinase2, a Novel ADAM17 Signaling Component, Regulates Tumor, Necerosis Factor a Ectodomain Shedding显示文摘 | Jeanette S Olga W Tomas K | 2014 | J Biol Chem2014，289，5： | 1 |
| 11 | Effect of specific interactions on structure property relationships of thermoplastic IPNs based on polyurethane and styrene-co-acrylic acid ionomers显示文摘 | Olga G Olga S Alexander B | 2007 | Macromolecular Symposia2007，254，1： | 1 |
| 12 | Typhoon eye trajectory based on a mathematical model: comparing with observational data 显示文摘 | Olga S Rozanova Jui-Ling YU Chin-Kun Hu | 2010 | Nonlinear Analysis: Real World Applications2010，11，3： | 1 |
| 13 | Air pollution dispersion within urban street canyons显示文摘 | OLGA V T MIKHAILUTA S V PITT A | | 0，，02： | 1 |
| 14 | Molecular mechanisms of biocatalytic desulfurization of fossil fuels显示文摘 | Kevin A G Olga S P Gregry T M Lei X Daniel J M Charles H S | 1996 | Nature Biotechnology1996，14，12： | 1 |
| 15 | Oscillation frequencies of tapered plant stems显示文摘 | Hanns-Christof S Olga S | 2002 | American Journal of Botany2002，89，1： | 1 |
| 16 | A fully automatable enzymatic method for DNA extraction from plant tissues显示文摘 | JEAN F M OLGA S LORENE A ALEXANDER V M ARKADY S | 2005 | BMC Plant Biology2005，23，： | 1 |
| 17 | Molecular mechanisms of biocatalytic desulfization of fossil fuels 显示文摘 | Kevin A G Olga S P | 1996 | Nature Biotechnol1996，14，： | 1 |
| 18 | Oscillation frequencies of tapered plant stems显示文摘 | Hanns-Christof S Olga S | 2002 | American Journal of Botany2002，89，1： | 1 |
| 19 | Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant Cancer 显示文摘 | Maha S Olga BG Tamara M | 2008 | Nanomedieine2008，3，6： | 1 |
| 20 | An effective method for the oxidation of aminofurazans to nitro-fura- zans 显示文摘 | Novikova Tat'yana S Mel'nikova Tat'yana M Kharitonova Olga V | 1994 | Mendeleev Commun1994，4，： | 1 |
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