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| 1 | Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing,China显示文摘背景中国是 Mycobacterium 的高负担国家之一肺结核(TB ) 感染全球性,与高发生和死亡。我们学习了 rifampin ( RIF )和抵抗 Mycobacterium 肺结核从中国北京拉紧的异菸肼( INH )的分子的特征,四十 pansusceptible 和 Mycobacterium 肺结核的 81 抵抗紧张从北京孤立以便为特定的药 resistance.Methods 的快速的察觉发现基因标记,中国在 2002-2005 期间被分析。修改 rifampin oligonucleotide (RIFO ) 试金基于反向的线污点杂交被用来在 rpoB 基因的 81 bp 热点区域检测变化,它与 RIF 抵抗被联系。INH 抵抗联系了基因,规章的区域 mab-inhA (-15C/T) 和结构的基因 katG S315T 被反向的线污点杂交和 PCR 限制碎片长度多型性(RFLP ) 检测方法分别地。所有紧张被 spoligotying 打,北京遗传型被 NTF 地点分析进一步细分。药抵抗的分发在上述基因联系了变化在这些 groups.Results 被比较 65 (91.5%) 抵抗的 71 RIF 并且 52 (92.9%) 56 multidrug 抵抗(MDR,对至少 RIF 和 INH 抵抗的 .e ) 紧张被发现在 rpoB 热点区域怀有变化。没有变化在 RIF 敏感紧张被检测。修改 RIFO 试金的特性和敏感是 100% 并且 91.5% 分别地。katG315 AGCACC 和 inhA-15CT 变化在 40 被发现(60.6%) 并且 10 (15.2%) 66 NH 抵抗紧张,分别地; 7.6%INH 抵抗的紧张在这两基因有变化。因此, katG315 和 inhA-15 的联合使用识别了 68.2%INH 抵抗的紧张。北京遗传型说明了 91.7% 全部的紧张并且进一步被细分进“现代”(76.6%) 并且“祖先”(23.4%) 组。在药的 prevaiance 的“祖先”、“现代”的组之间没有重要差别联系抵抗的基因 mutations.Conclusions rpoB 基因的热点区域能为 RIF 抵抗紧张的察觉被用作基因标记;katG315 和 inhA-15 的联合使用能改进 INH 抵抗紧张的察觉率;北京遗传型在中国北京是流行的;修改 RIFO 试金能是为抵抗的 RIF 的快速的察觉的一个实际工具, MDR 在平淡的诊断工作孤立。 | JIAO Wei-wei Mokrousov Igor SUN Gui-zhi LI Mo LIU Jia-wen Narvskaya Olga SHEN A-dong | 2007 | Chinese Medical Journal2007，，9： | 39 |
| 2 | Overlapping expression of microRNAs in human embryonic colon and colorectal cancer显示文摘MicroRNAs (miRNAs ) 为调整房间区别并且维持干细胞的 pluripotent 状态是必要的。尽管特定的 miRNAs 的 dysregulation 与癌症的某些类型被联系了,到日期,没有证据连接了 miRNA 表示在胚胎并且肿瘤纸巾。我们在人的胚胎的结肠组织,并且在 colorectal 癌症估计了成熟 miRNAs 的表示并且配对正常结肠组织。重叠 miRNA 表示在胚胎的结肠的 mucosa 和 colorectal 癌症之间被检测。我们发现了 miR-17-92 聚类,调整在两个盒子中的房间增长并且它的目标, E2F1,在人的冒号开发和结肠的 carcinogenesis 展出表示的一个类似的模式。在 situ,杂交在地窟祖先分隔空间证实了 miR-17-5p 的表示的高水平。我们断定 miRNA 小径在胚胎的开发和结肠的上皮的肿瘤的转变起一个主要作用。 | Mariano Monzo Alfons Navarro Eva Bandres Rosa Artells Isabel Moreno Bemat Gel Rafael Ibeas Jose Moreno Francisco Martinez Tania Diaz Antonio Martinez Olga Balague Jesus Garcia-Foncillas | 2008 | Cell Research2008，18，8： | 32 |
| 3 | Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury显示文摘Cell-based technologies are used as a therapeutic strategy in spinal cord injury(SCI). Mesenchymal stem cells(MSCs), which secrete various neurotrophic factors and cytokines, have immunomodulatory, anti-apoptotic and anti-inflammatory effects, modulate reactivity/phenotype of astrocytes and the microglia, thereby promoting neuroregeneration seem to be the most promising. The therapeutic effect of MSCs is due to a paracrine mechanism of their action, therefore the survival of MSCs and their secretory phenotype is of particular importance. Nevertheless, these data are not always reported in efficacy studies of MSC therapy in SCI. Here, we provide a review with summaries of preclinical trials data evaluating the efficacy of MSCs in animal models of SCI. Based on the data collected, we have tried(1) to establish the behavior of MSCs after transplantation in SCI with an evaluation of cell survival, migration potential, distribution in the area of injured and intact tissue and possible differentiation;(2) to determine the effects MSCs on neuronal microenvironment and correlate them with the efficacy of functional recovery in SCI;(3) to ascertain the conditions under which MSCs demonstrate their best survival and greatest efficacy. | Yana O.Mukhamedshina Olga A.Gracheva Dina M.Mukhutdinova Yurii A.Chelyshev Albert A.Rizvanov | 2019 | Neural Regeneration Research2019，14，2： | 25 |
| 4 | 3B染色体短臂小麦赤霉病抗性主效QTL的分析显示文摘采用区间作图和复合区间作图方法对重组自交系群体宁 894 0 37 Alondra、望水白 Alondra和苏麦 3号 Alon dra进行了抗赤霉病QTL分析 ,结果表明 ,用在田间和温室的赤霉病抗性鉴定资料 ,在 3个赤霉病抗源宁 894 0 37、望水白和苏麦 3号的 3B染色体短臂上均检测到主效QTL的存在。宁 894 0 37主效QTL位于标记BARC133与Xgwm4 93之间的 5 0cM的区间内 ,最高可解释 4 2 8%的赤霉病抗性 ;望水白的主效QTL位于标记BARC14 7与Xgwm4 93之间11 5cM的区间内 ,最高可解释 15 1%的赤霉病抗性 ;苏麦 3号的主效QTL位于Xgwm5 33a与Xgwm4 93之间 13 0cM的区间内 ,最高可解释 10 6 %的赤霉病抗性。与赤霉病抗性主效QTL紧密连锁的标记均为SSR标记 。 | 周淼平 任丽娟 张旭 Olga E Scholten 沈晓蓉 柏贵华 马鸿翔 陆维忠 | 2003 | Acta Genetica Sinica2003，30，6： | 22 |
| 5 | Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting显示文摘Glioblastomas(GBMs)are highly lethal primary brain tumors.Despite current therapeutic advances in other solid cancers,the treatment of these malignant gliomas remains essentially palliative.GBMs are extremely resistant to conventional radiation and chemotherapies.We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells(GSCs)promotes therapeutic resistance.We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth,which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs.Furthermore,stem cell-like cancer cells(cancer stem cells)have been shown to promote metastasis.Although GBMs rarely metastasize beyond the central nervous system,these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection,and GSCs display an aggressive invasive phenotype.These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment.Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells,but also display critical distinctions that provide important clues into useful therapeutic targets.In this review,we summarize the current understanding and advances in glioma stem cell research,and discuss potential targeting strategies for future development of anti-GSC therapies. | Zhi Huang Lin Cheng Olga A.Guryanova Qiulian Wu Shideng Bao | 2010 | Protein & Cell2010，1，7： | 18 |
| 6 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 7 | 大豆蛋白-淀粉基素肉制品高湿挤压工艺优化显示文摘采用双螺杆挤压机,以高直链玉米淀粉、大豆分离蛋白、谷朊粉为原料,应用高湿挤压技术制备大豆蛋白-淀粉素肉。探讨淀粉添加量(1%~5%)和喂料速度(10~50 g/min)、螺杆转速(60~180 r/min)、挤压温度(100~180℃)等操作参数对素肉的持水性和持油性的影响规律,并通过响应面优化得到最优参数。结果表明,淀粉添加量和操作参数对素肉的持水性和持油性有较大的影响,当淀粉添加量3%,喂料速度30 g/min,螺杆转速120 r/min,挤压温度140℃时,素肉持水性和持油性最优,分别为1.454 g/g和0.738 g/g。在最优条件下的素肉具有紧密的纤维组织状结构,硬度适宜,弹性和内聚性较好。 | 杨勇 王中江 陈惠惠 江连洲 王喜波 Olga Babich 李秋荣 | 2019 | 中国食品学报2019，19，12： | 16 |
| 8 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 9 | Autophagy and neurodegenerative disorders显示文摘Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. | Evangelia Kesidou Roza Lagoudaki Olga Touloumi Kyriaki-Nefeli Poulatsidou Constantina Simeonidou | 2013 | Neural Regeneration Research2013，8，24： | 15 |
| 10 | Chronic hepatitis B in pregnant women: Current trends and approaches显示文摘Chronic hepatitis B(CHB)is a significant public health problem worldwide.The aim of the present review is to summarize the actual trends in the management of CHB in pregnant women.The prevalence of hepatitis B virus(HBV)infection in pregnant women is usually comparable to that in the general population in the corresponding geographic area.All women have to be screened for hepatitis B surface antigen(HBsAg)during pregnancy.Additional examinations of pregnant women with CHB may include maternal hepatitis B e antigen,HBV viral load,alanine aminotransferase level,and HBsAg level.The management of pregnancy depends on the phase of the HBV infection,which has to be determined before pregnancy.In women of childbearing age with CHB,antiviral therapy can pursue two main goals:Treatment of active CHB,and vertical transmission prevention.During pregnancy,tenofovir is the drug of choice in both cases.A combination of hepatitis B immunoglobulin and vaccine against hepatitis B should be administered within the first 12 h to all infants born to mothers with CHB.In such cases,there are no contraindications to breastfeeding. | Maria Belopolskaya Viktor Avrutin Olga Kalinina Alexander Dmitriev Denis Gusev | 2021 | World Journal of Gastroenterology2021，27，23： | 15 |
| 11 | JAK-STAT pathway in carcinogenesis:Is it relevant to cholangiocarcinoma progression?显示文摘The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development. | Olga V Smirnova Tatiana Yu Ostroukhova Roman L Bogorad | 2007 | World Journal of Gastroenterology2007，13，48： | 14 |
| 12 | Oplopanax elatus(Nakai) Nakai: chemistry, traditional use and pharmacology显示文摘Oplopanax elatus(Nakai) Nakai, a member of the ancient angiosperm plant family Araliaceae, is used for the treatment of different disorders in the medicine systems of China, Russia, and Korea, and was designated in Russia as a classical adaptogen. Despite extensive studies of classical adaptogens, there are comparatively few reports concerning the chemical composition and pharmacological effects of O. elatus in English. The plant is a potential source of saponins, flavonoids, anthraquinones, terpenes, and other active compounds. Experimental studies and clinical applications have indicated that O. elatus possesses a number of pharmacological activities, including adaptogenic, anti-convulsant, anti-diabetic, anti-fungal, anti-inflammatory, anti-oxidant, blood pressure modulating, and reproductive function effects. In this review, the chemistry, safety, and therapeutic potential of O. elatus are summarized and highlighted to encourage the further development of this plant. | Alexander N.Shikov Olga N.Pozharitskaya Valery G.Makarov YANG Wen-Zhi GUO De-An | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 14 |
| 13 | 建成环境对步行和自行车出行的影响——以波哥大为例显示文摘哥伦比亚波哥大以可持续的城市交通系统闻名,包括其密集的自行车道网络以及Ciclovía系统——为骑车者和行人预留的道路空间,可在星期日和节假日休闲出行使用。探讨此类设施以及建成环境的其他属性——城市密度、混合用地、可达性以及与公共交通车站的距离——如何影响步行和自行车出行行为以及Ciclovía的使用。结果表明,道路设施设计要素例如道路密度、连通性、与Ciclovía车道的距离,与体力活动相关;而建成环境的其他属性如密度和用地混合程度,对体力活动影响甚微。这可能是由于波哥大建成区的大部分街区均在非机动交通出行占绝对优势的时期演变发展——紧凑、用地混合、交通可达性水平相似。由此可见,影响非机动交通出行的因素是设施设计而非一般的街区用地属性。 | Robert Cervero Olga L.Sarmiento Enrique Jacoby Luis Fernando Gomez Andrea Neiman 耿雪 | 2016 | 城市交通2016，14，5： | 13 |
| 14 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 15 | 工艺参数对层状液晶乳液结构的影响显示文摘讨论了由聚氧乙烯醚失水山梨醇脂肪酸酯、失水山梨醇脂肪酸酯、直链脂肪醇和挥发性物质组成的层状液晶乳液的制备过程中乳化时原料的加入顺序、乳化时间、冷却时搅拌速度及冷却时间对乳液的形态(脂质体结构,洋葱结构),特别是对乳液颗粒的粒径及粒径分布的影响。结果表明:乳化过程的时间对粒径的分布无明显影响;将水加入到含表面活性剂的油相中有利于形成完整结构的液晶乳液;冷却过程中的搅拌速度及搅拌时间对粒径的影响最大,为了得到较大颗粒为主的粒径分布,较佳冷却条件是搅拌速率在1 500 r/min、冷却60 min;慢速冷却有利于形成层间距较大的层状液晶,快速冷却易形成层间距略小的层状液晶。 | 李学静 Olga Gey Christian Quellet 田禾 | 2006 | 日用化学工业2006，36，3： | 12 |
| 16 | A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy显示文摘Malnutrition occurs frequently in patients with cancer.Indeed,a variety of nutritional and tumorrelated factors must be taken into account in these patients.Recognizing this relationship,we aimed to prospectively evaluate the risk factors that influence weight loss in patients undergoing radiotherapy with oral nutritional supplementation and dietetic counseling.Weight loss of 74 patients during radiotherapy and 1 month after treatment was analyzed.Parameters such as age,gender,tumor location,tumor stage,Eastern Cooperative Oncology Group performance status(ECOG PS)score,and the use of chemotherapy were analyzed to evaluate their influence on weight loss.All patients underwent oral nutritional supplementation and dietetic counseling.Forty-six(65.7%)patients lost weight,with a mean weight loss of(4.73±3.91)kg,during radiotherapy.At 1 month after treatment,45(66.2%)patients lost weight,presenting a mean weight loss of(4.96±4.04)kg,corresponding to a(6.84±5.24)%net reduction from their baseline weight.Head and neck cancer patients had a mean weight loss of(3.25±5.30)kg,whereas the remaining patients had a mean weight loss of(0.64±2.39)kg(P=0.028)during radiotherapy.In the multivariate analysis,the head and neck tumor location(P=0.005),use of chemotherapy(P=0.011),and ECOG PS score of 2-3(P=0.026)were considered independent risk factors.Nutritional status and parameters,such as tumor location(especially the head and neck),the use of chemotherapy,and the ECOG PS score,should be evaluated before radiotherapy because these factors can influence weight loss during radiotherapy and 1 month after treatment. | Jon Cacicedo Francisco Casquero Lorea Martinez-Indart Olga del Hoyo Alfonso Gomez de Iturriaga Arturo Navarro Pedro Bilbao | 2014 | Chinese Journal of Cancer2014，33，4： | 12 |
| 17 | Transgenerational Inheritance and Resetting of Stress, Induced Loss of Epigenetic Gene Silencing in Arabidopsis显示文摘作为无柄的有机体,植物需要察觉到并且适应异构的环境并且由改变他们的细胞的生理学,基因规定,和染色体稳定性开发了复杂回答。最近的工作在被建议具有 epigenetic 自然的 plantsa 现象在染色体稳定性的控制上表明了可继承的压力效果。这里,我们证明温度和 UV-B 应力在 Arabidopsis 在沉默记者基因的 epigenetic 控制引起立即、可继承的变化。基因 silencing 的这个调停压力的版本在 histone 占有并且在 histone H3 acetylation 与显著改变相关但是没在 DNA methylation 包含调整。我们在记者基因 silencing 上观察了压力效果的传播到非强调的子孙,但是这效果被限制为由房间的一个小数字组成的区域并且限制了到一些非强调的子孙代。而且,基因 silencing 的导致压力的版本在种子老化期间被反对并且重设。这现象的短暂性质加亮工厂的能力限制 epigenetic 控制机制的导致压力的松驰,它多半贡献保卫染色体完整。 | Christina Lang-Mladek Olga Popova Kathrin Kiok Marc Berlinger Branislava Rakic Werner Aufsatz Claudia Jonak Marie-Theres Hauser Christian Luschnig | 2010 | Molecular Plant2010，3，3： | 11 |
| 18 | 镉对生命活动的毒作用机制显示文摘镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。 | Alexey A.TINKOV Olga P.AJSUVAKOVA Jan AASETH Yordanka G.GLUHCHEVA Juliana M.IVANOVA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲 林雪 Anatoly V.SKALNY | 2018 | 环境与职业医学2018，35，5： | 11 |
| 19 | Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease显示文摘 | Xia Chen Kailin Yang Chen Wu Cheng Chen Can Hu Olga Buzovetsky Zefang Wang Xiaoyun Ji Yong Xiong Haitao Yang | 2016 | Cell Research2016，26，11： | 10 |
| 20 | Predicting anatomical results of surgical treatment of idiopathic macular hole显示文摘AIM: To determine the parameters most informative in predicting the anatomical results of surgical treatment of idiopathic full-thickness macular hole(IMH).·METHODS: One hundred and sixty-two consecutive patients(170 eyes) after primary operation for IMH were enrolled. Outcomes were classified as anatomical success when both IMH closure and restoration of the outer retinal structure were achieved. 'Prospective' group included 108 patients(115 eyes) followed with optical coherence tomography(OCT) and microperimetry for 1y after surgery. Potential prognostic criteria, except microperimetry data, were tested in 'retrospective' group(54 patients, 55 eyes). Prognostic value of each parameter was determined using receiver operating characteristic(ROC) analysis. Combined predictive power of the best prognostic parameters was tested with the use of linear discriminant analysis.·RESULTS: IMH closure was achieved in 106 eyes(92%)in the prospective group and 49 eyes(89%) in the retrospective group. Despite anatomical closure, the outer retinal structure was not restored in two eyes in the first group and in one eye in the second group.Preoperative central subfield retinal thickness demonstrated the best discriminatory capability between eyes with anatomical success and failure: area under the ROC-curve(AUC) 0.938(95% CI: 0.881-0.995), sensitivity64% at fixed specificity 95%(cut-off value 300 μm) in the prospective group; sensitivity 57% and specificity 90% in the retrospective group. Other continuous parameters except tractional hole index(AUC: 0.796, 95% CI: 0.591-1.000) had significantly lower AUCs(P <0.05). The best combination of the parameters, established by discriminant analysis in the prospective group, could not confirm its predictive value in the retrospective group.· CONCLUSION: Preoperative central subfield retinalthickness is a strong and probably the best predictor of anatomical results of IMH surgical treatment. | Alexander A.Shpak Dmitry O.Shkvorchenko Ilias Kh.Sharafetdinov Olga A.Yukhanova | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 10 |
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