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| 1 | Infiltrative xanthogranulomatous cholecystitis mimicking aggressive gallbladder carcinoma: A diagnostic and therapeutic dilemma显示文摘Xanthogranulomatous cholecystitis(XGC) is an uncommon variant of chronic cholecystitis. The perioperative findings in aggressive cases may be indistinguishable from those of gallbladder or biliary tract carcinomas. Three patients presented mass lesions that infiltrated the hepatic hilum,provoked biliary dilatation and jaundice,and were indicative of malignancy. Surgical excision was performed following oncological principles and included extirpation of the gallbladder,extrahepatic bile duct,and hilar lymph nodes,as well as partial hepatectomy. Postoperative morbidity was minimal. Surgical pathology demonstrated XGC and absence of malignancy in all three cases. All three patients are alive and well after years of follow-up. XGC may have such an aggressive presentation that carcinoma may only be ruled out on surgical pathology. In such cases,the best option may be radical resection following oncological principles performed by expert surgeons,in order that postoperative complications may be minimized if not avoided altogether. | Lucas Souto Nacif Amelia Judith Hessheimer Sonia Rodríguez Gómez Carla Montironi Constantino Fondevila | 2017 | World Journal of Gastroenterology2017，23，48： | 13 |
| 2 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 3 | Decompression of the Portal Bed and Twice-Baseline Portal Inflow Are Necessary for the Functional Recovery of a “Small-for-Size” Graft显示文摘 | Amelia J. Hessheimer Constantino Fondevila Pilar Taurá Javier Mu?oz Olga Sánchez José Fuster Antoni Rimola Juan Carlos García-Valdecasas | 2011 | Annals of Surgery2011，，6： | 2 |
| 4 | Portal Vein Thrombosis in Liver Transplantation显示文摘 | R. Charco J. Fuster C. Fondevila J. Ferrer E. Mans J.C. Garc??a-Valdecasas | 2005 | Transplantation Proceedings2005，，9： | 2 |
| 5 | Influence of the concentration of dietary digestible calcium on growth performance,bone mineralization, plasma calcium, and abundance of genes involved in intestinal absorption of calcium in pigs from 11 to 22 kg fed diets with different concentrations of显示文摘Background: A 21-day experiment was conducted to test the hypothesis that Ca requirements to maximize growth performance expressed as the standardized total tract digestible(STTD) Ca to STTD P ratio is less than 1.40:1. The second hypothesis was that increasing dietary Ca increases plasma Ca concentration and downregulates abundance of genes related to Ca absorption(TRPV6, S100 G, and ATP2 B1) in the duodenum, and tight junction proteins(OCLN, CLDN1, and ZO1) in the duodenum and ileum.Methods: Twenty corn-soybean meal diets were formulated using a 4 × 5 factorial design with diets containing 0.16%, 0.33%, 0.42%, or 0.50% STTD P, and 0.14%, 0.29%, 0.44%, 0.59%, or 0.74% STTD Ca. Six hundred and forty pigs(initial weight: 11.1 ± 1.4 kg) were allotted to 20 diets and 5 blocks in a randomized complete block design. On day21, weights of pigs and feed left in feeders were recorded and blood, duodenal tissue, ileal mucosa, and the right femur were collected from 1 pig per pen. Abundance of m RNA was determined in duodenal and ileal tissue via quantitative RT-PCR. Data were analyzed using a response surface model.Results: The predicted maximum ADG(614 g), G:F(0.65), and bone ash(11.68 g) was obtained at STTD Ca:STTD P ratios of 1.39:1, 1.25:1, and 1.66:1, respectively, when STTD P was provided at the requirement(0.33%). If dietary STTD P was below the requirement, increasing dietary Ca resulted in reduced(P < 0.05) ADG and G:F. However, if dietary STTD P was above the requirement, negative effects(P < 0.05) on ADG and G:F of increasing STTD Ca were observed only if dietary STTD Ca exceeded 0.6%. Plasma Ca concentration was positively affected by STTD Ca over the range studied(quadratic, P < 0.01) and negatively affected by increasing STTD P(linear, P < 0.01). There was a linear negative effect(P < 0.05) of STTD Ca on the abundance of S100 G, TRPV6, OCLN, and ZO1 in duodenum, and CLDN and ZO1 in ileum.Conclusions: The STTD Ca:STTD P ratio needed to maximize growth performance of 11-to 25-kg pigs is less than1.40:1, if P is at the estimated requirement. Increasing dietary Ca reduces transcellular absorption of Ca and increases paracellular absorption of Ca. | L.Vanessa Lagos Su A.Lee Guillermo Fondevila Carrie L.Walk Michael R.Murphy Juan J.Loor Hans H.Stein | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 2 |
| 6 | Anticoagulati on in pregnant woman with mechanical heart valve prostheses显示文摘 | Meschengieser SS Fondevila CG Santarelli MT | 1999 | Heart1999，82，1： | 1 |
| 7 | Degradation and utilization of forage hemicellulose by rumen bacteria, singly in coculture or added sequentially显示文摘 | Fondevila M Dehority BA | 1994 | J App1 Bacteriol1994，77，5： | 1 |
| 8 | Hepatic ischemia/reperfusion injury-a fresh look显示文摘 | FONDEVILA C BUSUTTIL R W KUPIEC WEGLINSKI J W | 2003 | Exp Mol Pathol2003，74，2： | 1 |
| 9 | Hepatic ischemia/reperfusion injury—a fresh look显示文摘 | Constantino Fondevila Ronald W Busuttil Jerzy W Kupiec-Weglinski | 2003 | Experimental and Molecular Pathology2003，，2： | 1 |
| 10 | Superior preservation of DCD livers with continuous normothermic perfusion显示文摘 | Fondevila C Hessheimer AJ Maathuis MH | 2011 | Ann Surg2011，254，6： | 1 |
| 11 | Effect of combinations of organic acids on gastric microbiology of weaned piglets显示文摘 | FRANCO L D FONDEVILA M MOTA M | 2005 | Archivos de Zootecnia2005，53，203： | 1 |
| 12 | p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer 显示文摘 | Fondevila C Metges JP Fuster J | 2004 | Br J Cancer2004，90，1： | 1 |
| 13 | Labo- ratory variation of 24 h in vitro gas production and estimated metabo- lizable energy values of ruminant feeds 显示文摘 | GETACHEW G CROVETTO G M FONDEVILA M | 2002 | Anita Feed Sci Tech2002，102，： | 1 |
| 14 | Extracorpo- real machine liver perfusion 显示文摘 | Hessheimer A J Fondevila C Garcia-Valdeeasas JC | 2012 | Curr Opin Organ Transplant2012，17，2： | 1 |
| 15 | Superior preservation of DCD livers with continuous normothermic perfusion显示文摘 | Fondevila C Hessheimer AJ Maathuis MHJ | 2011 | Ann Surg2011，254，： | 1 |
| 16 | Fibroneefin-α4131 Interactions in Hepatic Cold Ischemia and Reperfusion Injury: Regulation of MMP-9 and MT1-MMP via the p38 MAPK Pathway显示文摘 | Duarte S Shen XD Fondevila C | 2012 | Am J Transplant2012，12，10： | 1 |
| 17 | Fibronectin‐α4β1 Interactions in Hepatic Cold Ischemia and Reperfusion Injury: Regulation of MMP‐9 and MT1‐MMP via the p38 MAPK Pathway显示文摘 | S. Duarte X.‐D. Shen C. Fondevila R. W. Busuttil A. J. Coito | 2012 | American Journal of Transplantation2012，，10： | 1 |
| 18 | Graft and viral outcomes in retransplantation for hepatitis C virus recurrence and HCV primary liver transplantation: a case–control study显示文摘 | Josep Martí Sofia De la Serna Gonzalo Crespo Xavier Forns Joana Ferrer Constantino Fondevila Miquel Navasa Josep Fuster Juan Carlos García‐Valdecasas | 2014 | Clin Transplant2014，，7： | 1 |
| 19 | Hepatic ischemia/reperfusion injury - - a fresh look 显示文摘 | Fondevila C Busuttil RW Kupiec - Weglinski JW | 2003 | Exp Mol Pathol2003，74，1： | 1 |
| 20 | Effect of ammonia treat and carbohydrate supplementation on the intake and digestibility of barley straw diets by sheep显示文摘 | Castrillo C Fondevila M Guada J A | 1995 | Anim Feed Sci Technol1995，51，： | 1 |
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