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| 1 | Current status of diagnosis and treatment of hepatic echinococcosis显示文摘Echinococcus granulosus(E.granulosus) and Echinococcus multilocularis(E.multilocularis) infections are the most common parasitic diseases that affect the liver.The disease course is typically slow and the patients tend to remain asymptomatic for many years.Often the diagnosis is incidental.Right upper quadrant abdominal pain,hepatitis,cholangitis,and anaphylaxis due to dissemination of the cyst are the main presenting symptoms.Ultrasonography is important in diagnosis.The World Health Organization classification,based on ultrasonographic findings,is used for staging of the disease and treatment selection.In addition to the imaging methods,immunological investigations are used to support the diagnosis.The available treatment options for E.granulosus infection include open surgery,percutaneous interventions,and pharmacotherapy.Aggressive surgery is the first-choice treatment for E.multilocularis infection,while pharmacotherapy is used as an adjunct to surgery.Due to a paucity of clinical studies,empirical evidence on the treatment of E.granulosus and E.multilocularis infections is largely lacking;there are no prominent and widely accepted clinical algorithms yet.In this article,we review the diagnosis and treatment of E.granulosus and E.multilocularis infections in the light of recent evidence. | Memmet Mihmanli Ufuk Oguz Idiz Cemal Kaya Uygar Demir Ozgur Bostanci Sinan Omeroglu Emre Bozkurt | 2016 | World Journal of Hepatology2016，8，28： | 50 |
| 2 | Recent developments and innovations in gastric cancer显示文摘Gastric cancer has an important place in the worldwide incidence of cancer and cancer-related deaths. It can metastasize to the lymph nodes in the early stages, and lymph node metastasis is an important prognostic factor. Surgery is a very important part of gastric cancer treatment. A D2 lymphadenectomy is the standard surgical treatment for c T1N+ and T2-T4 cancers, which are potentially curable. Recently, the TNM classification system was reorganized, and the margins for gastrectomy and lymphadenectomy were revised. Endoscopic, laparoscopic and robotic treatments of gastric cancer have progressed rapidly with development of surgical instruments and techniques, especially in Eastern countries. Different endoscopic resection techniques have been identified, and these can be divided into two main categories: endoscopic mucosal resection and endoscopic submucosal dissection. Minimally invasive surgery has been reported to be safe and effective for early gastric cancer, and it can be successfully applied to advanced gastric cancer with increasing experience. Cytoreductive surgery and hypertherm?c intraper?toneal chemotherapy were developed as a combined treatment modality from the results of experimental and clinical studies. Also, hyperthermia increases the antitumor activity and penetration of chemotherapeutics. Trastuzumab which is a monoclonal antibody interacts with human epidermal growth factor(HER) 2 and is related to gastric carcinoma. The anti-tumor mechanism of trastuzumab is not clearly known, but mechanisms such as interruption of the HER2-mediated cell signaling pathways and cell cycle progression have been reported previously. H. pylori is involved in 90% of all gastric malignancies and Japanese guidelines strongly recommend that all H. pylori infections should be eradicated regardless of the associated disease. In this review, we present innovations discussed in recent studies. | Mehmet Mihmanli Enver Ilhan Ufuk Oguz Idiz Ali Alemdar Uygar Demir | 2016 | World Journal of Gastroenterology2016，22，17： | 29 |
| 3 | Maastricht Ⅱ treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori显示文摘AIM: The Maastricht Ⅱ criteria suggest the use of amoxicillin and clarithromycin in addition to a proton pump inhibitor over 7-10 d as a first line therapy in the eradication of Helicobacter pylori (Hpylori). For each proton pump inhibitor, various rates of eradication have been reported. The present study was to compare the efficacy of different proton pump inhibitors like omeprazole, lansoprazole and pantoprazole in combination with amoxicillin and clarithromycin in the first line eradication of Hpylonand to investigate the success of H pylonrieradication in our district. METHODS: A total of 139 patients were included having a Helicobacter pylori (+) gastroduodenal disorders diagnosed by means of histology and urease test. Besides amoxicillin (1000 mg twice a day) and darithromycin (500 mg twice a day), they were randomized to take omeprazole (20 mg twice a day), or lansoprazole (30 mg twice a day), or pantoprozole (40 mg twice a day) for 14 d. Four weeks after the therapy, the eradication was assessed by means of histology and urease test. It was evaluated as eradicated if the Hpyloriwas found negative in both. The complaints (pain in epigastrium, nocturnal pain, pyrosis and bloating) were graded in accordance with the Licert scale. The compliance of the patients was recorded. RESULTS: The eradication was found to be 40.8% in the omeprazole group, 43.5% in the lansoprazole group and 47.4% in the pantoprazole group. Sixty-three out of 139 patients (45%) had eradication. No statistically significant difference was observed between the groups. Significant improvements were seen in terms of the impact on the symptom scores in each group. CONCLUSION: There was no difference between omeprazole, lansoprazole and pantoprazole in H pylori eradication, and the rate of eradication was as low as 45%. Symptoms were improved independent of the eradication in each treatment group. The low eradication rates suggest that the antibiotic resistance or the genetic differences of the microorganism might be in effect. Further studies are required to verify these suggestions. | EnginAltintas OrhanSezgin Oguz Ulu Ozlem Avdin Handan Camdeviren | 2004 | World Journal of Gastroenterology2004，10，11： | 23 |
| 4 | Etiology and portal vein thrombosis in Budd-Chiari syndrome显示文摘AIM: To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS: A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultrasonography, duplex ultrasonography and venography were analyzed. Hemogram and blood chemistry were studied at the time of diagnosis and on each hospital visit. Bone marrow examination and immune phenotyping were performed by a hematologist when necessary. Protein C, S, antithrombin Ⅲ, activated protein C resistance, and anticardiolipin antibodies, antinuclear antibodies, and anti ds-DNA were studied twice. The presence of ascite, esophageal varices, and portal thrombosis were evaluated at admission and on every visit. RESULTS: At least one etiological factor was determined in 54 (72%) of the patients. The etiology could not be defined in 21 (28%) patients. One etiological factor was found in 39, 2 factors in 14 and 3 factors in 1 patient. The most common cause was the web (16%), the second was Hydatid disease (11%), the third was Behcet’s disease (9%). Portal vein thrombosis was present in 11 patients and at least one etiology was identified in 9 of them (82%). CONCLUSION: Behcet’s disease and hydatid disease are more prominent etiological factors in Turkey than in other countries. Patients with web have an excellent response to treatment without signs of portal veinthrombosis while patients having thrombofilic factors more than one are prone to develop portal vein thrombosis with worse clinical outcome. | Oguz Uskudar Meral Akdogan Nurgul Sasmaz Sevinc Yilmaz Muharrem Tola Burhan Sahin | 2008 | World Journal of Gastroenterology2008，14，18： | 14 |
| 5 | Blood rheology and aging显示文摘The flow properties of blood play significant roles in tissue perfusion by contributing to hydrodynamic resistance in blood vessels. These properties are influenced by pathophysiological processes, thereby increasing the clinical relevance of blood rheology information. There is well-established clinical evidence for impaired blood fluidity in humans of advanced age, including enhanced plasma and whole blood viscosity, impaired red blood cell (RBC) deformability and enhanced RBC aggregation. Increased plasma fibrinogen concentration is a common finding in many studies owing to the pro-inflammatory condition of aged individuals;this finding of increased fibrinogen concen-tration explains the higher plasma viscosity and RBC aggregation in elderly subjects. Enhanced oxidant stress in advanced age is also known to contribute to altered blood fluidity, with RBC deformability being an important determinant of blood viscosity. Several studies have shown that physical activity may improve the hemorheological picture in elderly subjects, yet well-designed observational and mechanistic studies are required to determine the specific effects of regular exercise on hemorheological parameters in healthy and older individuals. | Michael J. Simmonds Herbert J. Meiselman Oguz K. Baskurt | 2013 | Journal of Geriatric Cardiology2013，10，3： | 9 |
| 6 | Choice of drugs in the treatment of chronic hepatitis B in pregnancy显示文摘The selection of antiviral drugs for chronic hepatitis B(CHB) treatment in pregnancy is very difficult since none of the drugs have been approved for use in pregnancy.Transmission from mother to newborn remains the most frequent route of infection in mothers with high viral load and positive hepatitis B e antigen status,even with the use of appropriate prophylaxis with hepatitis B virus(HBV) immunoglobulin and HBV vaccination.We read from the article written by Yi et al that lamivudine treatment in early pregnancy was safe and effective.However,we could not understand why adefovir dipivoxil(ADV) was used in three pregnancy cases,since ADV has been classified as pregnancy category C.In pregnancy,telbivudine or tenofovir should be selected when the treatment of CHB is necessary,since these drugs have been classified as Food and Drug Administration pregnancy risk category B. | Ertugrul Guclu Oguz Karabay | 2013 | World Journal of Gastroenterology2013，19，10： | 9 |
| 7 | Dynamic contrast-enhanced magnetic resonance imaging of prostate cancer: A review of current methods and applications显示文摘In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from the intravascular space to the capillary bed due to leaky capillaries associated with tumor neovascularity. DCE-MRI has the potential to provide information regarding blood flow, areas of hypoperfusion, and variations in endothelial permeability and microvessel density to aid treatment selection, enable frequent monitoring during treatment and assess response to targeted therapy following treatment. This review will discuss the current status of DCE-MRI in cancer imaging, with a focus on its use in imaging prostate malignancies as well as weaknesses that limit its widespread clinical use. The latest techniques for quantification of DCE-MRI parameters will be reviewed and compared. | Yousef Mazaheri Oguz Akin Hedvig Hricak | 2017 | World Journal of Radiology2017，9，12： | 8 |
| 8 | H pylori:Treatment for the patient only or the whole family?显示文摘AIM:To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS:H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living together (groupⅠ) or patients only (group Ⅱ). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS:There were 70 H pylori-positive patients in each group;patients in groupsⅠand Ⅱ lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in groupⅠpatients and 38.6% in group Ⅱ patients [P < 0.01, OR = 8.61 95% confidence interval (CI):2.91-22.84]. CONCLUSION:The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high;they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection. | Yavuz Selim Sari Didem Can Vahit Tunali Orhan Sahin Oguz Koc Omer Bender | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 9 | Relationship between intestinal microbiota and colorectal cancer显示文摘The human gastrointestinal tract hosts a complexand vast microbial community with up to 1011-1012 microorganisms colonizing the colon. The gut microbiota has a serious effect on homeostasis and pathogenesis through a number of mechanisms. In recent years, the relationship between the intestinal microbiota and sporadic colorectal cancer has attracted much scientific interest. Mechanisms underlying colonic carcinogenesis include the conversion of procarcinogenic diet-related factors to carcinogens and the stimulation of procarcinogenic signaling pathways in luminal epithelial cells. Understanding each of these mechanisms will facilitate future studies, leading to the development of novel strategies for the diagnosis, treatment, and prevention of colorectal cancer. In this review, we discuss the relationship between colorectal cancer and the intestinal microbiota. | Gokhan Cipe Ufuk Oguz Idiz Deniz Firat Huseyin Bektasoglu | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 7 |
| 10 | Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning显示文摘Parasitic infections constitute a major global public health issue.Existing screening methods that are based on manual microscopic examination often struggle to provide sufficient volumetric throughput and sensitivity to facilitate early diagnosis.Here,we demonstrate a motility-based label-free computational imaging platform to rapidly detect motile parasites in optically dense bodily fluids by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism.Based on this principle,a cost-effective and mobile instrument,which rapidly screens~3.2 mL of fluid sample in three dimensions,was built to automatically detect and count motile microorganisms using their holographic time-lapse speckle patterns.We demonstrate the capabilities of our platform by detecting trypanosomes,which are motile protozoan parasites,with various species that cause deadly diseases affecting millions of people worldwide.Using a holographic speckle analysis algorithm combined with deep learningbased classification,we demonstrate sensitive and label-free detection of trypanosomes within spiked whole blood and artificial cerebrospinal fluid(CSF)samples,achieving a limit of detection of ten trypanosomes per mL of whole blood(~five-fold better than the current state-of-the-art parasitological method)and three trypanosomes per mL of CSF.We further demonstrate that this platform can be applied to detect other motile parasites by imaging Trichomonas vaginalis,the causative agent of trichomoniasis,which affects 275 million people worldwide.With its costeffective,portable design and rapid screening time,this unique platform has the potential to be applied for sensitive and timely diagnosis of neglected tropical diseases caused by motile parasites and other parasitic infections in resource-limited regions. | Yibo Zhang Hatice Ceylan Koydemir Michelle M.Shimogawa Sener Yalcin Alexander Guziak Tairan Liu Ilker Oguz Yujia Huang Bijie Bai Yilin Luo Yi Luo Zhensong Wei Hongda Wang Vittorio Bianco Bohan Zhang Rohan Nadkarni Kent Hill Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 11 | Checklist for early recognition and treatment of acute illness:International collaboration to improve critica care practice显示文摘Processes to ensure world-wide best-practice for critical care delivery is likely to minimize preventable death, disability and costly complications for any healthcare system's sickest patients, but no large-scale efforts have so far been undertaken towards these goals. The advances in medical informatics and human factors engineering have provided possibility for novel and user-friendly clinical decision support tools that can be applied in a complex and busy hospital setting. To facilitate timely and accurate best-practice delivery in critically ill patients international group of intensive care unit(ICU) physicians and researchers developed a simple decision support tool: Checklist for Early Recognition and Treatment of Acute Illness(CERTAIN). The tool has been refined and tested in high fidelity simulated clinical environment and has been shown to improve performance of clinical providers faced with simulated emergencies. The aim of this international educational intervention is to implement CERTAIN into clinical practice in hospital settings with variable resources(included those in low income countries) and evaluate the impact of the tool on the care processes and patient outcomes. To accomplish our aims, CERTAIN will be uniformly available on either mobile or fixed computing devices(as well as a backup paper version) and applied in a standardized manner in the ICUs of diverse hospitals. To ensure the effectiveness of the proposed intervention, access to CERTAIN is coupled with structured training of bedside ICU providers. | Marija Vukoja Rahul Kashyap Srdjan Gavrilovic Yue Dong Oguz Kilickaya Ognjen Gajic | 2015 | World Journal of Critical Care Medicine2015，4，1： | 5 |
| 12 | 响应面法优化电炉炼钢粉尘中Zn的选择性浸出显示文摘研究浸出参数对电炉炼钢粉尘灰中选择浸出性Zn的影响,以Zn和Fe的浸出率为响应变量,以硫酸浓度、浸出温度、浸出时间和液固比为独立变量,采用基于三水平Box-Behnken的响应面法对浸出参数进行优化。对试验结果进行ANOVA分析和验证。在硫酸浓度为2.35 mol/L,浸出温度为25℃,浸出时间为56.42 min,液固比为5的条件下,可得到Zn的最大浸出率为79.09%,Fe的最小浸出率为4.08%。通过ANOVA分析表明,对Zn和Fe浸出率影响最大的因素为硫酸浓度和浸出温度。基于响应面法的模型与试验数据具有很好的一致性,Zn和Fe浸出率的相关系数分别为0.98和0.97。 | Mehmet KUL Kürsad Oguz OSKAY Mehmet SIMSIR Halit SüBüTAY Habip KIRGEZEN | 2015 | Transactions of Nonferrous Metals Society of China2015，25，8： | 5 |
| 13 | 2012年北美放射学年会前列腺影像学最新研究进展显示文摘第98届北美放射学年会(RSNA 2012)在美国芝加哥召开,该届大会共收录与前列腺相关的论文共58篇,以MRI为主,超声、PET等技术在前列腺中的的论文相对较少。这些论文主要关注于不同成像技术间的组合和优化在前列腺癌诊断与鉴别诊断中的应用价值。作者对以上方面的研究进展进行综述,旨在为我国前列腺影像学研究提供新的思路。 | 李亮 冯朝燕 Jinxiang Yu Oguz Akin 王良 | 2013 | 磁共振成像2013，4，3： | 4 |
| 14 | Treatment of chronic hepatitis B patients with tyrosinemethionine-aspartate-aspartate mutations显示文摘Lamivudine is an antiviral used for the treatment of chronic hepatitis B. Several studies have reported various mutations that are induced by lamivudine therapy. These mutations in the tyrosine-methionineaspartate-aspartate(YMDD) motif are necessary and sufficient to confer high-level lamivudine resistance. During treatment with lamivudine, mutations develop in the YMDD motif of the hepatitis B virus(HBV) polymerase gene and lamivudine cannot prevent the replication of the mutant form. The virulence strain of developed mutation in the polymerase gene is lower than the original virus and they are susceptible to treatment with some other nucleoside analogs except lamivudine. Entecavir and tenofovir are potent HBV inhibitors and they can be confidently used as first line monotherapies. We read the article written by Tan et al that lamivudine therapy improved the clinical course in HBV patients with natural YMDD mutations. We think that lamivudine use for this patient group is not appropriate. These patients should use YMDD mutant form-effective drugs such as adefovir, tenofovir. | Aylin Calica Utku Oguz Karabay | 2016 | World Journal of Gastroenterology2016，22，4： | 4 |
| 15 | Incidence of accessory ossicles and sesamoid bones in the feet: a radiographic study of the Turkish subjects显示文摘 | Nigar Coskun Mehtap Yuksel Metin Cevener R. Yavuz Arican Hakan Ozdemir Oguz Bircan Timur Sindel Sezgin Ilgi Muzaffer Sindel | 2009 | Surgical and Radiologic Anatomy2009，，1： | 3 |
| 16 | Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience显示文摘 | C. Kekik S.K. Besisik Y. Seyhun F.S. Oguz D. Sargin M.N. Carin | 2009 | Transplantation Proceedings2009，，9： | 2 |
| 17 | A geriatric patient with diffuse idiopathic skeletal hyperostosis显示文摘The most frequent health problems seen in senility are chronic and degenerative diseases. A 75-year-old male patient with the complaints of weight loss and difficulty in swallowing was admitted to our hospital from a nursing home. Upper system fiber-optic gastrointestinal endoscopy was performed and a mass at the junction of the hypopharynx and esophagus just below recessus piriformis obstructing almost the whole of the lumen and blocking the distal passage was detected. Computed tomography revealed marked narrowing secondary to osseous hypertrophy in the air column of the hypopharynx and proximal esophagus. Diffuse idiopathic skeletal hyperostosis or Forestier’s disease is an idiopathic disease characterized by the ossification of the anterior longitudinal ligament of vertebra and some of the extraspinal ligaments. In the present case we aim to discuss an elderly patient who suffered from dysphagia and weight loss and the diagnostic stages. | Berrin Karadag Huseyin Cat Selma Aksoy Banu Ozulu Ali Osman Ozturk Sukru Oguz Yuksel Altuntas | 2010 | World Journal of Gastroenterology2010，16，13： | 2 |
| 18 | Development of Chromium(Ⅲ)-selective Potentiometric Sensor by Using Synthesized Pyrazole Derivative as an lonophore in PVC Matrix and its Applications显示文摘A novel poly(vinyl chloride)membrane potentiometric sensor for chromium(Ⅲ)ions based on the use of 5,5′-(1,4-phenylene)bis(3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide)as a neutral ionophore was developed.The optimum composition of the best performing membrane contained ionophore,potassium tetrakis(p-chlorophenyl)borate(KTpClPB),dibutyl phthalate(DBP),and poly(vinyl chloride)(PVC)in the ratio of 5.5:1.5:55:38(mg).The sensor exhibits a working concentration range of 1.0×10^(-5)-1.0×10^(-1 )mol L^(−1) and a detection limit of 1.7×10^(-6) mol L^(−1).The sensor shows good selectivity for chromium(III)ions over a number of cations including alkali,alkaline earth,heavy and transition metals.The response time of the sensor is 8 s.In addition,the developed sensor shows good reusability and stability.The sensor operates in the wide pH range of 5.0-11.0.The sensor could be used as an indicator electrode in the quantification of Cr^(3+)ions by potentiometric titration against ethylenediaminetetraacetic acid(EDTA).Finally,this sensor was successfully used for the determination of chromium(III)in commercial water,purification water and wastewater. | Ömer Isildak OguzÖzbek Meliha Burcu Gürdere | 2020 | Journal of Analysis and Testing2020，4，4： | 2 |
| 19 | Blue code: Is it a real emergency?显示文摘BACKGROUND: Cardiac arrests in hospital areas are common, and hospitals have rapid response teams or 'blue code teams' to reduce preventable in-hospital deaths. Education about the rapid response team has been provided in all hospitals in Turkey, but true 'blue code' activation is rare, and it is abused by medical personnel in practice. This study aimed to determine the cases of wrong blue codes and reasons of misuse.METHODS: This retrospective study analyzed the blue code reports issued by our hospital between January 1 and June 1 2012. A total of 89 'blue code' activations were recorded in 5 months. A 'blue code' was defined as any patient with an unexpected cardiac or respiratory arrest requiring resuscitation and activation of a hospital alert. Adherence to this definition, each physician classified their collected activation forms as either a true or a wrong code. Then, patient data entered a database(Microsoft Excel 2007 software) which was pooled for analysis. The data were analyzed by using frequencies and the Chi-square test on SPSSv16.0.RESULTS: The patients were diagnosed with cardiopulmonary arrest(8), change in mental status(18), presyncope(11), chest pain(12), conversive disorder(18), and worry of the staff for the patient(22). Code activation was done by physicians in 76% of the patients; the most common reason for blue code was concern of staff for the patient.CONCLUSION: The findings of this study show that more research is needed to establish the overall effectiveness and optimal implementation of blue code teams. | Serkan E.Eroglu Ozge Onur Oguz Urgan Arzu Denizbasi Haldun Akoglu | 2014 | World Journal of Emergency Medicine2014，5，1： | 2 |
| 20 | A new classification and guide for surgical treatment of spinal tuberculosis显示文摘 | E. Oguz A. Sehirlioglu M. Altinmakas C. Ozturk M. Komurcu C. Solakoglu A. R. Vaccaro | 2008 | International Orthopaedics2008，，1： | 2 |
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