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| 1 | Adverse effects of oral antiviral therapy in chronic hepatitis B显示文摘Oral nucleoside/nucleotide analogues(NAs) are currently the backbone of chronic hepatitis B(CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of patients have been treated with NAs. Safety data has accumulated over the years. The aim of this article is to review and update the adverse effects of oral NAs. NAs can cause class adverse effects(i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. All NAs carry a 'Black Box' warning because of the potential risk for mitochondrial dysfunction. However, these adverse effects are rarely reported. The majority of cases are associated with lamivudine and telbivudine. Adefovir can lead to dose- and time-dependent nephrotoxicity, even at low doses. Tenofovir has significant renal and bone toxicity in patients with human immunodeficiency virus(HIV) infection. However, bone and renal toxicity in patients with CHB are not as prominent as in HIV infection. Entecavir and lamivudine are not generally associated with renal adverse events. Entecavir has been claimed to increase the risk of lactic acidosis in decompensated liver disease and high Model for End-Stage Liver Disease scores. However, current studies reported that entecavir could be safely used in decompensated cirrhosis. An increase in fetal adverse events has not been reported with lamivudine, telbivudine and tenofovir use in pregnant women, while there is no adequate data regarding entecavir and adefovir. Further long-term experience is required to highlight the adverse effects of NAs, especially in special patient populations, including pregnant women, elderly and patients with renal impairment. | Bircan Kayaaslan Rahmet Guner | 2017 | World Journal of Hepatology2017，9，5： | 17 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Incidence of accessory ossicles and sesamoid bones in the feet: a radiographic study of the Turkish subjects显示文摘 | Nigar Coskun Mehtap Yuksel Metin Cevener R. Yavuz Arican Hakan Ozdemir Oguz Bircan Timur Sindel Sezgin Ilgi Muzaffer Sindel | 2009 | Surgical and Radiologic Anatomy2009，，1： | 3 |
| 4 | Immunohistochemical analysis of c-myc,c-jun and estrogen receptor in normal,hyperplastic and neoplastic endometrium显示文摘 | Bircan S Ensari A Ozturk S | 2005 | Pathol Oncol Res2005，11，1： | 1 |
| 5 | Immunohistochemical analysis of c - Myc, c - Jun and estrogen receptor in normal, hyperplastic and neoplastic endometrium显示文摘 | Bircan S Ensari A Ozturk S | 2005 | Pathol Oncol2005，11，1： | 1 |
| 6 | C - reactive protein levels in patients with chronic obstructive pulmonary disease: role of in- fection显示文摘 | Bircan A Gokirmak M Kilic O | 2008 | Med Princ Pract2008，17，3： | 1 |
| 7 | A Clinical Trial of Mediterranean Diet Enriched with Fatty Fish in Pediatric Asthma: Study Protocol显示文摘 | Maria Michelle Papamichael Chaffs Katsardis Dimitffs Tsoukalas Bircan Erbas Catherine Itsiopoulos | 2018 | Journal of Pharmacy and Pharmacology2018，6，3： | 1 |
| 8 | CD24 expression in duetal carcinoma in situ and invasive duetal carcinoma of breast: an immunohistochemistry-based pilot study 显示文摘 | Bircan S Kapucuoglu N Baspinar S | 2006 | Pathol Res Praet2006，202，8： | 1 |
| 9 | Intravenous cyclophosphamide is the drug of choice for steroid depend nephrotic syndrome显示文摘 | Bircan Z Kara B | 2003 | Pediatr Nephrol2003，45，1： | 1 |
| 10 | Relationship between osteopenic syndrome and severity of coronary artery disease detected with coronary angiography and Gensini score in men 显示文摘 | Bircan Alan Veysi Akpolat Adem Aktan | 2016 | Clin Interv Aging2016，11，： | 1 |
| 11 | Primary clear cell sarco- ma of rib显示文摘 | Hersekli M A Ozkoc G Bircan S | 2005 | Skeletal Radiol2005，34，3： | 1 |
| 12 | Intravenous cyclophosphamide is the drug of choice for steroid dependent nephrotic syndrome显示文摘 | Bircan Z Kara B | 2003 | Pediatr Int2003，45，1： | 1 |
| 13 | Two novel mutations in the sixth transmembrane segment of the thyrotrop in receptor gene causing hyperfunctioning thyroid nodules 显示文摘 | Gozu H Avsar M Bircan R | 2005 | Thyroid2005，15，4： | 1 |
| 14 | prognostic factor for thyroid papillary Is has Himoto's thyroiditis a oma? 显示文摘 | Bircan HY Koc B Akarsu C | 2014 | Eur Rev Med Pharmacol Sci2014，18，13： | 1 |
| 15 | Demand for education in Turkey: A Tobit analysis of private tutoring expenditures显示文摘 | Aysit Tansel & Fatma Bircan | 2006 | Economic of Education Review2006，25，： | 1 |
| 16 | CD24 expression in duc tal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study 显示文摘 | Bircan S Kapucuoglu N Baspinar S | 2006 | Pathol Res Pract2006，202，8： | 1 |
| 17 | CD24 expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: An immunohis-tochemistry-based pilot study 显示文摘 | Bircan S Kapucuoglu N Baspinar S | 2006 | Pathol Res Pract2006，202，8： | 1 |
| 18 | CIY24 expression in ductal carcinoma in situ and invasive ductal carcinoma of breast:an immunohistochemistry-based pilot study显示文摘 | Bircan S Kapucuoglu N Baspinar S | | 0，，08： | 1 |
| 19 | The dielectric properties of meats as a function of temperature and composition显示文摘 | Sipahioglu O Barringer S A Bircan C | 2003 | The Journal of Microwave Power and Electromagnetic Energy2003，38，3： | 1 |
| 20 | C-reactive protein,leukocyte count and ESR in the assessment of severity of community-acquired pneumonia显示文摘 | Bircan A Kaya O Gokirmak M | 2006 | Tuberk Toraks2006，54，1： | 1 |
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