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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 3 | Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience显示文摘 | C. Kekik S.K. Besisik Y. Seyhun F.S. Oguz D. Sargin M.N. Carin | 2009 | Transplantation Proceedings2009，，9： | 2 |
| 4 | Influence of proanthocyanidin on blunt traumatized lungs after nitrogen mustard exposure显示文摘 | YUCEL O SARGIN A K TEKINER A | 2009 | Gulhane Tip Dergisi2009，51，： | 1 |
| 5 | Comparison of lunch and bedtime NPH insulin plus mealtime insulin lispro therapy with premeal regular insulin plus bedtime NPH insulin therapy in type 2 diabetes显示文摘 | SARGIN H SARGIN M ALTUNTAS Y | 2003 | Diabetes Res Clin Pract2003，62，2： | 1 |
| 6 | Gastrointestinal complications after cardiopulmonary bypass:sixteen years of experience显示文摘 | Bolcal C Iyem H Sargin M | 2005 | Can J Gastroenterol2005，19，10： | 1 |
| 7 | A randomized comparison of different doses of intrathecal levobupivacaine combined with fentanyl for elective cesarean section:prospective,double-blinded study显示文摘 | Gunusen I Karaman S Sargin A | 2011 | J Anesth2011，25，2： | 1 |
| 8 | Erythropoietin as neuroprotective and neuroregenerative treatment strategy:comprehensive overview of 12 years of preclinical and clinical research显示文摘 | Sargin D Friedrichs H El-Kordi A | 2010 | Best Pract Res Clin Anaesthesiol2010，24，4： | 1 |
| 9 | Expression of constitutivelyactive erythropoietin receptor in pyramidal neurons of cortex andhippocampus boosts higher cognitive functions in mice显示文摘 | Sargin D El-Kordi A Agarwal A | 2011 | BMCBiol2011，9，： | 1 |
| 10 | S100A2 induces metastasis in non- small cell lung cancer显示文摘 | Bulk E Sargin B Krug U | 2009 | Clin Cancer Res2009，15，1： | 1 |
| 11 | Audiovisual synchronization and fusion using canonical correlation analysis显示文摘 | ME Sargin Y Yemez | 2007 | IEEE Transac- tions on Multimedia2007，9，7： | 1 |
| 12 | Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer显示文摘 | Cengiz Gemici Mehmet Sargin Oya Uygur-Bayramicli Alpaslan Mayadagli Gokhan Yaprak Resat Dabak Mihriban Kocak | 2013 | Radiotherapy and Oncology2013，，2： | 1 |
| 13 | Erythropoietin as neu- roprotective and neuroregenerative treatment strategy: compre- hensive overview of 12 years of preclinical and clinical research 显示文摘 | Sargin D Friedriehs H E1-Kordi A | 2010 | Best Pract Res Clin Anaesthesiol2010，24，4： | 1 |
| 14 | Variable length open contour track-ing using a deformable trellis显示文摘 | Mehmet Emre Sargin Alphan Altnok Bangalore SManiunath | 2011 | IEEE Trans on ImageProcessing2011，20，4： | 1 |
| 15 | Recombinant human erythropoietin in the treatment of human brain disease:focus On cognition显示文摘 | Ehrenreich H Bartels C sargin D et a1 | 2008 | Ren Nutr2008，1，8： | 1 |
| 16 | Role of post- prandial bile acids in prediction of perinatal outcome in intra- hepatic eholestasis of pregnancy显示文摘 | SARGIN ORUC A SECK1N B OZCAN N | 2014 | J Ohstet Gynaecol Res2014，40，7： | 1 |
| 17 | Doppler study of myometrium in invasive gestational trophoblastic disease显示文摘 | Oguz S Sargin A Aytan H | 2004 | Int J Gynecol Cancer2004，14，5： | 1 |
| 18 | Cystic hygroma and lymphangioma:associated findings,perinatal outcome and prognostic factors in live-born infants显示文摘 | Gedikbasi A Gul A Sargin A | 2007 | Arch Gynecol Obstet2007，276，5： | 1 |
| 19 | Growth mechanisms of polypyrroles显示文摘 | SARGIN P S TOPPARE L YURTSEVER E | 1996 | Polymer1996，37，7： | 1 |
| 20 | Diagnosis of peutalogy of cantrell in the first trimester using transvaginal sonography and color doppler 显示文摘 | Ttirkqapar AF Sargin Oruc A 0kstizoglu A | 2015 | Case Rep Obstet Gynecol2015，2015，17： | 1 |
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