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| 1 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 2 | Risk aspects of dental restoratives: From amalgam to tooth-colored materials显示文摘Dental materials' choice of patients has considerably changed. Whereas cast gold and amalgam have been the predominant biomaterials for decades, today toothcolored materials like resin-based composites and ceramics are more and more successful. However, are we going to replace a good but biologically questionable material(amalgam) with an equal material(resin composite) being more esthetic but also biologically questionable? For amalgam, long-term clinical studies reported some significant hints that in single cases amalgam may be a health hazard for patients, finally Norway banned amalgam completely. The main advantage of a resin-based composite over amalgam is its tooth-like appearance and more or less absence of extensive preparation rules. For many years it was believed that resin-based composites may cause pulpal injury. However, pulpal injury associated with the use of resin-based composites is not correlated with their cytotoxic properties. Nevertheless, resin-based composites and other dental materials require rigorous safety evaluation and continuous monitoring to prevent adverse events similar like with amalgam. Because of nonbiocompatible pulp responses to resin-based composites and amalgam, they should not be placed in direct contact with the dental pulp. The less dentin remaining in the floor of preparations between resin-based composites or other dental materials is more likely to cause pulpitis. Percentage of patients and dental practitioners who display allergic reactions is between 0.7% and 2%. The release of cytotoxic monomers from resin-based materials is highest after polymerization and much lower after 1 wk. Substances released from resin-based composites have been shown to be toxic in cytotoxicity tests. Nevertheless, in vitro cytotoxicity assays have shown that amalgam has greater toxic effects than resin-based composites, sometime 100-700-fold higher. Altogether, the risk of side-effects is low, but not zero, especially for dental personnel. | Roland Frankenberger Franklin Garcia-Godoy Peter E Murray Albert J Feilzer Norbert Kr?mer | 2013 | World Journal of Stomatology2013，2，1： | 1 |
| 3 | Interference free and simpyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes 显示文摘 | Maurice NK Norbert E Philipe NK ct al | 2005 | J Chromatogr B2005，821，： | 1 |
| 4 | Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries 显示文摘 | Henk J Wisselink Hilde E Smitha Norbert Stockhofe-Zurwiedenb | 2000 | Vete Micr2000，74，3： | 1 |
| 5 | Bioavailability of apomorphine following intranasal administration of mu_ coadhesive drug delivery systems in rabbits显示文摘 | Michael IU Sam E Norbert V | 1999 | Eur J Pharm Sci1999，9，： | 1 |
| 6 | Development of an instrument to electronically measure, record and image washover of a towed body显示文摘 | Norbert E Y James H C | 2003 | Applied Ocean Research2003，，25： | 1 |
| 7 | Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response显示文摘 | Dazert Eva Neumann-Haefelin Christoph Bressanelli Stéphane Fitzmaurice Karen Kort Julia Timm J?rg McKiernan Susan Kelleher Dermot Gruener Norbert Tavis John E Rosen Hugo R Shaw Jaqueline Bowness Paul Blum Hubert E Klenerman Paul Bartenschla | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 8 | What makes a fragrance substantive? 显示文摘 | PETER M M NORBERT N J FRANZ E | 1993 | Perfumer& Havorist1993，18，4： | 1 |
| 9 | On the oxidation and combustion of A1H3 a potential fuel for rocket propellants and gas generators 显示文摘 | Volker W Norbert E Andresa K | 2007 | Propellants Explosives Pyrotechnics2007，32，3： | 1 |
| 10 | 显示文摘 | Norbert E Bernhard N Bemd E | 1998 | J Electrochem Soc1998，145，5： | 1 |
| 11 | Cell tropism of Staphylococcus aureus in bovine mammary gland cell cultures显示文摘 | Aart Lammers Piet J.M Nuijten Ellard Kruijt Norbert Stockhofe-Zurwieden Uri Vecht Hilde E Smith Fred G van Zijderveld | 1999 | Veterinary Microbiology1999，，2： | 1 |
| 12 | Fast emission spectroscopy for a better understanding of pyrotechnic combustion behavior显示文摘 | Volker W Norbert E | 2005 | Propellants Explosives Pyrotechnics2005，30，1： | 1 |
| 13 | Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-γ/TNF-α in HT-29 cells显示文摘 | Norbert W Lutz Margaret E Tome Patrick J Cozzone | 2003 | FEBS Letters2003，，1： | 1 |
| 14 | On the mechanism of low temperature oxidation for aluminum particles down to the nano-scale 显示文摘 | Norbert E | 2004 | PropeUants Explosives Pyrotechnics2004，29，3： | 1 |
| 15 | Measuring the thickness of clear freshwater ice using geometric optics and a spectrometer显示文摘 | Norbert E etc | 2005 | Cold Regions Science and Technology2005，43，3： | 1 |
| 16 | Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response显示文摘 | Dazert Eva Neumann-Haefelin Christoph Bressanelli Stéphane Fitzmaurice Karen Kort Julia Timm J?rg McKiernan Susan Kelleher Dermot Gruener Norbert Tavis John E Rosen Hugo R Shaw Jaqueline Bowness Paul Blum Hubert E Klenerman Paul Bartenschla | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 17 | 显示文摘 | Norbert E Bernhard N Bernd E | 1998 | J Electrochem Soc1998，145，5： | 1 |
| 18 | Formation of drug- arysulfonate complexes inside liposomes:A novel approach to im- prove drug retention 显示文摘 | IGOR VZ NORBERT M KATARINA E | 2006 | J Control Release2006，110，2： | 1 |
| 19 | Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism显示文摘 | Nicole Maas-Szabowski Akira Shimotoyodome Norbert E Fuse nig | 1999 | J Cell Science1999，112，： | 1 |
| 20 | Human lymphocyte apoptosis after exposure to influenza A virus显示文摘 | JOAN E N JEAN A N NORBERT J R | 2001 | J Virol2001，75，13： | 1 |
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