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| 1 | CA19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease显示文摘BACKGROUND:CA19-9 is a carbohydrate tumor-associated antigen which is frequently upregulated in pancreatobiliary neoplasia.However,it may also be elevated in patients with jaundice in the absence of a tumor due to biliary obstruction,and in other non-hepato-pancreatico-biliary conditions.This study aimed to evaluate whether CA19-9 levels could accurately differentiate between benign and malignant pancreatobiliary disease.METHODS:All patients referred to a single surgeon for investigation of pancreaticobiliary disease in 2003 in whom a firm diagnosis had been established were included.For malignant disease,a histological diagnosis was required but for benign disease a firm radiological diagnosis was deemed adequate.The patients were divided into 4 categories:pancreatic adenocarcinoma(PCa);cholangiocarcinoma(CCa);chronic pancreatitis(CP)and biliary calculous disease(Calc).Bilirubin and alkaline phosphatase levels corresponding to the point of assessment of CA19-9 were also noted.RESULTS:Final diagnoses were made of pancreatic adenocarcinoma(PCa,n=73),cholangiocarcinoma(CCa,n=19),ampullary carcinoma(Amp,n=7),neuroendocrine carcinoma(Neu,n=4),duodenal carcinoma(Duo,n=3),chronic pancreatitis(CP,n=115),and biliary calculous disease(Calc,n=27).Median CA19-9 levels(U/ml)were:PCa,653;CCa,408;Duo,403;Calc,27;CP,19;Neu,10.5;Amp,8(reference range:0-37).The CA19-9 levels were significantly greater for malignant than for benign disease,could differentiate PCa from CCa/Duo,and were significantly higher in unresectable than in resectable PCa.The sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)for CA19-9 were 84.9%,69.7%,67.7%and 86.1%,respectively.A ROC analysis provided an area under the curve for CA19-9 of 0.871(0.820-0.922),giving an optimal CA19-9 of 70.5 U/ml for differentiating benign from malignant pathology.Using this cut-off,the sensitivity was 82.1%,while specificity,PPV and NPV improved to 85.9%,81.3%and 86.5%,respectively.When standard radiology was included(US/ CT/MRCP)in the decision process,the results improved to 97.2%,88.7%,86.6%,and 97.7%.For benign disease,the CA19-9 correlated directly with the serum bilirubin,but for malignant disease,CA19-9 levels were elevated independent of the bilirubin level.CONCLUSIONS:CA19-9 is useful in the differentiation of pancreatobiliary disease and when using an optimized cut-off and combining with routine radiology,the diagnostic yield is improved significantly,thus stressing the importance of a multi-disciplinary approach to pancreatobiliary disease. | Gareth Morris-Stiff Mary Teli Nicky Jardine Malcolm CA Puntis | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 33 |
| 2 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 3 | Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing显示文摘We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer.As opposed to conventional microneedle fabrication methods,this technique neither requires complex and expensive manufacturing facilities nor expertise in microfabrication.While most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness,we show that by introducing a two-step“Print&Fill”mold fabrication method,it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating tissue.Studying first the effect of varying design input parameters and print settings,it is shown that printed needles are always shorter than specified.With decreasing input height,needles also begin displaying an increasingly greater than specified needle base diameter.Both factors contribute to low aspect ratio needles when attempting to print submillimeter height needles.By setting input height tall enough,it is possible to print needles with high-aspect ratios and tip radii of 20–40μm.This tip sharpness is smaller than the specified printer resolution.Consequently,high-aspect ratio sharp needle arrays are printed in basins which are backfilled and cured in a second step,leaving sub-millimeter microneedles exposed resulting microneedle arrays which can be used as male masters.Silicone female master molds are then formed from the fabricated microneedle arrays.Using the molds,both carboxymethyl cellulose loaded with rhodamine B as well as polylactic acid microneedle arrays are produced and their quality examined.A skin insertion study is performed to demonstrate the functional capabilities of arrays made from the fabricated molds.This method can be easily adopted by the microneedle research community for in-house master mold fabrication and parametric optimization of microneedle arrays. | Kevin J.Krieger Nicky Bertollo Manita Dangol John T.Sheridan Madeleine M.Lowery Eoin D.O’Cearbhaill | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 4 | The impact of cruise ship generated waste on home ports and ports of call: A study of Southampton显示文摘 | Nickie Butt | 2007 | Marine Policy2007，，5： | 2 |
| 5 | NON-DESTRUCTIVE ANALYSIS OF THE NUCLEI OF TRANSGENIC LIVING CELLS USING LASER TWEEZERS AND NEAR-INFRARED RAMAN SPECTROSCOPIC TECHNIQUE显示文摘Transgenic cell lines of loblolly pine (Pinus taeda L.) were analyzed by a compact laser-tweezers-Raman-spectroscopy (LTRS) system in this investigation. A low power diode laser at 785 nm was used for both laser optical trapping of single transgenic cells and excitation for near-infrared Raman spectroscopy of the nuclei of synchronized cells, which were treated as single organic particles, at the S-phase of the cell cycle. Transgenic living cells with gfp and uidA genes were used as biological samples to test this LTRS technique. As expected, di?erent Raman spectra were observed from the tested biological samples. This technique provides a high sensitivity and enables real-time spectroscopic measurements of transgenic cell lines. It could be a valuable tool for the study of the fundamental cell and molecular biological process by trapping single nucleus and by providing a wealth of molecular information about the nuclei of cells. | Wei Tang Ronald J. Newton Chang-An Xie Yong-Qing Li Nicki Whitley | 2005 | Genomics, Proteomics & Bioinformatics2005，3，3： | 2 |
| 6 | Women's Jobs Do Make a Difference:A Reply to Goldthorpe显示文摘 | Anthony Health and Nicky Britten | 1984 | Sociology1984，18，4： | 1 |
| 7 | 'Doing prescribing':how doctors can be more effective显示文摘 | Glyn Elwyn Adrian Edwards Nicky Brittem | 2003 | BMJ2003，327，7419： | 1 |
| 8 | Comparison of PCR-based marker systems for the analysis of genetic relationships in cultivated potato显示文摘 | Dan Milbourne Rhonda Meyer John E. Bradshaw Eileen Baird Nicky Bonar Jim Provan Wayne Powell Robbie Waugh | 1997 | Molecular Breeding1997，，2： | 1 |
| 9 | Occupational exposure to diisocyanates in polyurethane foam factory workers显示文摘 | WIERCZY SKA-MACHURA D BRZE NICKI S NOWAKOWSKA-WIRTA E | 2015 | Int J Occup Med Environ Health2015，28，6： | 1 |
| 10 | Helicobacter pylori porCDAB andoorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases whichmediate electron transport to NADP显示文摘 | Nicky J Hughes Chris L Clayton Peter A Chalk | 1998 | Journal of bacteriology1998，180，5： | 1 |
| 11 | Honeys from Different Floral Sources as lnhibitors of Enzymatic Browning in Fruit and Vegetable Homogcnates 显示文摘 | LEI CHEN AMAR MEHTA MAY BERENBAUM ARTHUR R ZANGERL and NICKI J ENGESETH | 2000 | J Agric Food Chem2000，，48： | 1 |
| 12 | Qualitative research: qualitative interviews in medical research显示文摘 | Nicky Britten | 1995 | British Medical Journal1995，311，： | 1 |
| 13 | Five-Level triage:A report from trs,ACEP/ENA five-level triage Task force 显示文摘 | Christopher M Paula T Nicki G etal | 2005 | J Emerg Nurs2005，31，： | 1 |
| 14 | A comparison of Bayesian spatial models for disease mapping显示文摘 | Nicky B Sylvia R Thomson A | 2005 | Stat Methods Med Res2005，149，1： | 1 |
| 15 | 项目群管理中组织间关系对网络位置的影响研究显示文摘项目群管理将大量相关联的项目进行集成和控制,其复杂性和管理难度远远大于单纯的大项目或多项目,嵌入到合作关系网络中的业主、承包商、分包商、咨询公司通过共享信息和资源来完成庞大的项目群。文章运用案例分析方法研究一家大型水务企业项目群,研究发现业主与八个大型承包商之间组织间关系的复杂性表现为:八个大型承包商负责五个工种,而且大型承包商的项目群周期个数存在差异。通过社会网络分析法中心性分析、基于工种的中心性分析和信息共享网络社会关系图发现节点项目群周期个数越多,越容易处于网络位置中心,节点点入度比点出度高更能反映节点影响力。 | 李清 Nicky Shaw | 2017 | 技术经济与管理研究2017，，9： | 1 |
| 16 | Serum and peritoneal fluid CA125 concentration in women with endometriosis显示文摘 | Kra(s)nicki D | | 0，，12： | 1 |
| 17 | Tuberculosis infection prevention and control:why we need a whole systems approach显示文摘Infection prevention and control(IPC)measures to reduce transmission of drug-resistant and drug-sensitive tuberculosis(TB)in health facilities are well described but poorly implemented.The implementation of TB IPC has been assessed primarily through quantitative and structured approaches that treat administrative,environmental,and personal protective measures as discrete entities.We present an on-going project entitled Umoya omuhle(“good air”),conducted in two provinces of South Africa,that adopts an interdisciplinary,‘whole systems’approach to problem analysis and intervention development for reducing nosocomial transmission of Mycobacterium tuberculosis(Mtb)through improved IPC.We suggest that TB IPC represents a complex intervention that is delivered within a dynamic context shaped by policy guidelines,health facility space,infrastructure,organisation of care,and management culture.Methods drawn from epidemiology,anthropology,and health policy and systems research enable rich contextual analysis of how nosocomial Mtb transmission occurs,as well as opportunities to address the problem holistically.A‘whole systems’approach can identify leverage points within the health facility infrastructure and organisation of care that can inform the design of interventions to reduce the risk of nosocomial Mtb transmission. | Karina Kielmann Aaron S.Karat Gimenne Zwama Christopher Colvin Alison Swartz Anna S.Voce Tom A.Yates Hayley MacGregor Nicky McCreesh Idriss Kallon Anna Vassall Indira Govender Janet Seeley Alison D.Grant | 2020 | Infectious Diseases of Poverty2020，9，3： | 1 |
| 18 | Criterion validation of the edinburgh postnatal depression scale as a screening tool for depression in patients with advanced metastatic cancer显示文摘 | Mari LW Trevor F Nicky R | 2000 | J Pain Symptom Manage2000，20，4： | 1 |
| 19 | Evidence - based nursing: past,present,and future显示文摘 | Alba Nicky C Donna C | 2000 | Evid Based Nurs2000，3，1： | 1 |
| 20 | Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial显示文摘 | Justin CT Pepperell Sharon Ramdassingh-Dow Nicky Crosthwaite Rebecca Mullins Crispin Jenkinson John R Stradling Robert JO Davies | 2002 | 2002 (9302)2002，，9302： | 1 |
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