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| 1 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 2 | Alkali and Silane Treatments towards Exemplary Mechanical Properties of Kenaf and Pineapple Leaf Fibre-reinforced Composites显示文摘Following the contemporary research trend of exploring the potential of eco-friendly natural fibres,this work studies the effects of alkali and silane treatments,with varying concentrations,on the mechanical characterization of composites reinforced with kenaf and pineapple leaf fibre(PALF).Kenaf-and PALF-based composites were fabricated through the heat compression method.Their mechanical characterization was then performed to evaluate the tensile,flexural and impact properties.The findings concluded that chemical treatments indeed enhanced the mechanical properties of composite materials.5%NaOH and 3%silane treatments can respectively provide the optimum mechanical properties to the kenaf fibre and PALF reinforced composites.Chemical treatment results evidenced that silane-treated composites exhibit higher mechanical properties compared to the NaOH-treated composites.When comparing the mechanical properties of kenaf-and PALF-reinforced polypropylene composites,the overall results show that composites based on PALF have superior mechanical properties. | Ng Lin Feng Sivakumar Dhar Malingam Nadlene Razali Sivarao Subramonian | 2020 | Journal of Bionic Engineering2020，17，2： | 3 |
| 3 | Dendrobium candi- dum extract increases the expression of aquaporino5 in labial glands from patients with Sj6gren's syndrome 显示文摘 | Lin Xiao Tzi Bun Ng Yi-Bin Feng | 2011 | Phytomedicine2011，18，： | 1 |
| 4 | Surface Studies of the Rearrangement of End Groups of a Polymer by ToF-SIMS and AFM显示文摘 | Lin Li Kai-Mo Ng Chi-Ming Chan Ji-Yun Feng Xin-Miao Zeng | 2000 | Macromolecules2000，33，： | 1 |
| 5 | Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjogren syndrome显示文摘 | Lin Xiao Ng TB Feng YB | 2011 | Phytomedicine2011，18，23： | 1 |
| 6 | Physics and astrophysics of strong magnetic field systems with eXTP显示文摘In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s. | Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef Jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li Lin Lin Roberto Mignani Nanda Rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit Paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 7 | Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives [Beta]-catenin/T cell factor-dependent hepatocarcinogenesis显示文摘 | Feng Hai Cheng Alfred S L Tsang Daisy P Li May S Go Minnie Y Cheung Yue S Zhao Gui-jun Ng Samuel S Lin Marie C Yu Jun Lai Paul B To Ka F Sung Joseph J Y | 2011 | Journal of Clinical Investigation2011，，8： | 1 |
| 8 | The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells显示文摘 | Jian-Chien Dominic Heng Bo Feng Jianyong Han Jianming Jiang Petra Kraus Jia-Hui Ng Yuriy L. Orlov Mikael Huss Lin Yang Thomas Lufkin Bing Lim Huck-Hui Ng | 2010 | Cell Stem Cell2010，，2： | 1 |
| 9 | Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant显示文摘It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged globally.The coronavirus disease 2019(COVID-19)has greatly influenced human society.According to data from the World Health Organization(WHO),there were over 656 million confirmed cases of COVID-19 in the world as of January 1,2023,including over 6.6 million deaths[1]. | Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen | 2024 | World Journal of Pediatrics2024，20，3： | 0 |
| 10 | Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome显示文摘Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with PCOS.However,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been confirmed.Methods:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established disease.The serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was evaluated.Results:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with PCOS.The serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ovaries.Notably,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated groups.Network pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also closely involved.Conclusion:KT1A and KT1S treatments both significantly ameliorated the PCOS-related pathology in rats,suggesting that the hippocampus component is dispensable for KT1S-mediated amelioration.Given the limited resources and global demand for wild hippocampus for use in complementary medicines,our findings may help conserve this species.Together,our results suggest that KT1A is a promising approach for treating PCOS. | Leanne Lee Leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng Leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin Kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng | 2022 | Traditional Medicine Research2022，7，3： | 0 |
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