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| 1 | 失弛缓症患者血清可改变正常人胃底肠肌间神经丛化学信号和NO介导的反应显示文摘Background and aims: Achalasia is a disease of unknown aetiology. An immune mechanism has been suggested on the basis of previous morphological observations. The objective of this study was to test whether the serum of achalasia patients could reproduce the phenotype and functional changes that occur with disease progression in an ex vivo human model. Methods: Specimens of normal human fundus were maintained in culture in the presence of serum from patients with achalasia, gastro-oesophageal reflux disease (GORD), or healthy subjects (controls). Immunohistochemical detection of choline acetyltransferase (ChAT), neurone specific enolase (NSE), vasoactive intestinal polypeptide (VIP), nitric oxide synthase (NOS), and substance P was carried out in whole mounts of gastric fundus myenteric plexus. In addition, the effects of achalasia serum on electrical field stimulation (EFS) induced contractions were measured in circular muscle preparations. Results: Serum from achalasia patients did not affect the number of myenteric neurones. Tissues incubated with serum from achalasia patients showed a decrease in the proportion of NOS (- 26% of NSE positive neurones; p = 0.016) and VIP (- 54% ; p = 0.09) neurones, and a concomitant increase in ChAT neurones (+ 16% ; p< 0.001) compared with controls. In contrast, GORD serum did not modify the phenotype of myenteric neurones. Area under the curve of EFS induced relaxations (abolished by N-nitro-L-arginine methyl ester) was significantly decreased following incubation with serum from achalasia patients compared with controls (- 7.6 (2.6) v - 14.5 (5.0); p = 0.036). Conclusions: Serum from achalasia patients can induce phenotypic and functional changes which reproduce the characteristics of the disease. Further identification of putative seric factors and mechanisms involved could lead to the development of novel diagnostic and/or therapeutic strategies in achalasia. | Bruley Des Varannes S. Chevalier J. Pimont S. M. Neunlist 程妍(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 3 |
| 2 | Colonic bi- opsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms显示文摘 | Lebouvier T Neunlist M Bruley des Varannes S | 2010 | PLoS One2010，5，12： | 1 |
| 3 | A Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways显示文摘 | Neunlist M Toumi F Oreschkova T | | 0，，05： | 1 |
| 4 | Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms显示文摘 | Lebouvier T Neunlist M Bruley des Varannes S | 2010 | PLoS One2010，5，12： | 1 |
| 5 | Enteric glia inhibit intesti- nal epithelial cell proliferation partly through a TGF-/31-dependent pathway 显示文摘 | Neunlist M Aubert P Bonnand S | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，1： | 1 |
| 6 | Starring roles for astroglia in barrier pathologies of gut and brain 显示文摘 | Savidge TC Sofroniew MV Neunlist M | 2007 | Lab Invest2007，87，8： | 1 |
| 7 | Isotopic biogeochemistry of the lipids in recent sediments of lake Bled (Slovenia) and Baldeggersee (Switzerland) 显示文摘 | Neunlist S Rodier C Llopiz P | 2002 | Organic Geochemistry2002，33，： | 1 |
| 8 | The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease显示文摘 | Neunlist M Van Landeghem L Mahe MM | 2013 | Nat Rev Gastroenterol Hepatol2013，10，： | 1 |
| 9 | Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an ILl beta-dependent pathway 显示文摘 | NEUNLIST M BAROUK J MICHEL K | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，5： | 1 |
| 10 | Enteric glial cells: new players in Parkinson's disease? 显示文摘 | Clairembault T Leclair-Visonneau L Neunlist M | 2015 | Mov Disord2015，30，： | 1 |
| 11 | Isotopic Biogeoehemistry of the lipids in Recent Se~diments of Lake Bled(Slovenia)and Baldeggersee(Switzerland)显示文摘 | Rodier C Lioplz P | 2002 | Org Oeochem2002，33，： | 1 |
| 12 | Colonic biopsies to assess the neuropathology of Parkinson'sdisease and its relationship with symptoms 显示文摘 | LEBOUVIER T NEUNLIST M BRULEY DES VARANNES S | 2010 | PloS one2010，5，9： | 1 |
| 13 | Colonic biopsies to assess the neuropathology of Parkinson's Disease and its relationship with symptoms 显示文摘 | LEBOUVIER T NEUNLIST M BRULRY DES VARANNES S | 2010 | Plos One2010，5，12： | 1 |
| 14 | Enteric glia inhibit in- testinal epithelial cell proliferation partly through a TGF-betal- dependent pathway 显示文摘 | Neunlist M Aubert P Bonnaud S | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，1： | 1 |
| 15 | Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms显示文摘 | Lebouvier T Neunlist M Bruley des Varannes S | 2010 | PLoS One2010，5，12： | 1 |
| 16 | Intestinal epithelial celldysfunction is mediated by an endothelial-sperifir radiation-induredbystander effect显示文摘 | Gaugler MH Neunlist M Bonnaud S | 2007 | Radiat Res2007，167，2： | 1 |
| 17 | Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats显示文摘 | Rodolphe Soret Julien Chevalier Pierre De Coppet Guillaume Poupeau Pascal Derkinderen Jean Pierre Segain Michel Neunlist | 2010 | Gastroenterology2010，，5： | 1 |
| 18 | Human ENS regulates the intestinal epithelial barrier permeability and a tight junction - associated protein ZO - 1 via VIPergic pathways 显示文摘 | Neunlist M Toumi F Oreschkova T | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，5： | 1 |
| 19 | Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S -Nitrosoglutathione显示文摘 | Tor C. Savidge Paul Newman Charalabos Pothoulakis Anne Ruhl Michel Neunlist Arnaud Bourreille Roger Hurst Michael V. Sofroniew | 2007 | Gastroenterology2007，，4： | 1 |
| 20 | Enteric glial cells: New players in Parkinson’s disease?显示文摘 | Thomas Clairembault Laurène Leclair‐Visonneau Michel Neunlist Pascal Derkinderen | 2015 | Mov Disord2015，，4： | 1 |
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