|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 卫星观测到的青藏高原雷电活动特征显示文摘利用TRMM卫星上携带的闪电探测系统获取的闪电定位资料首次对青藏高原上的闪电活动进行了研究。研究发现,青藏高原上的闪电活动呈现出大陆性气候特征,但是受其特殊地形的热力和动力特征所调制,高于93%的闪电活动发生于5~9月之间,并在夏季出现单一闪电活动峰值。随着地表加热和湿度的增加,闪电活动在5月份开始明显增加。较高的闪电密度发生在高原的中部,揭示了闪电活动与地形特征的相关性。63%的闪电活动发生于14:00~18:00(地方时,下同)之间,而只有<3%的闪电发生于00:00~10:00之间。闪电光辐射能的时平均值也呈现出明显的日变化,随着太阳的升起,闪电光辐射能在08:00开始增加,并在10:00达到稳定的极大值,直到02:00开始明显减小。闪电的光辐射能在高原北部呈现最大值,高原西部呈现最小值。青藏高原上的闪电放电强度比其它地区弱得多,其差别归因于高原上较低的对流不稳定能量。 | 郄秀书 Ralf Toumi | 2003 | 高原气象2003，22，3： | 61 |
| 2 | Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs), including Crohn's disease and ulcerative colitis are complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result from an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. The dysfunction of the mucosal immune response is implicated in the pathogenesis of IBD. The balance between pro-inflammatory cytokines [tumor necrosis factor(TNF)-α, interleukin(IL)-1b, IL-8, and IL-17A], anti-inflammatory cytokines(IL-4 and IL-13), and immunoregulatory cytokines(IL-10 and transforming growth factors b) is disturbed. Moreover, evidence from animal and clinical studies demonstrate a positive correlation between an increased concentration of nitric oxide(NO) and the severity of the disease. Interestingly, proinflammatory cytokines are involved in the up-regulation of inducible oxide synthase(iN OS) expression in IBD. However, anti-inflammatory and immunoregulatory cytokines are responsible for the negative regulation of iN OS. A positive correlation between NO production and increased pro-inflammatory cytokine levels(TNF-α, IL-6, IL-17, IL-12, and interferon-γ) were reported in patients with IBD. This review focuses on the role of cytokines in intestinal inflammation and their relationship with NO in IBD. | Imene Soufli Ryma Toumi Hayet Rafa Chafia Touil-Boukoffa | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，3： | 30 |
| 3 | 闪电的光辐射能分布特征显示文摘对TRMM卫星上装载的闪电成像仪(LIS)所获取的闪电光辐射能进行了分析,发现在不同地区和不同的空间、时间尺度上闪电光辐射能都很好地遵循对数正态分布。文中利用了一个国际上公认的一维雷暴云起电和放电模式,对闪电放电中和的电荷量进行了数值模拟。蒙特卡罗算法表明,闪电放电所中和的电荷量也遵循对数正态分布,云中的软雹浓度、破碎系数、温度递减率、放电的电场阈值等参量的综合作用可以对其进行较好的解释,而其中任意一种参量的单独作用则不然。 | 郄秀书 谢屹然 Ralf Toumi | 2004 | 高原气象2004，23，4： | 6 |
| 4 | 盐酸美金刚在中国治疗阿尔茨海默病的药物经济学模型显示文摘目的探讨从中度阿尔茨海默病(AD)开始盐酸美金刚治疗与仅从重度AD开始盐酸美金刚治疗在中国的临床和经济效益。方法运用马尔可夫模型,通过定义患者的不同健康状况,模拟了中度AD患者在5年中的疾病进展。研究对两组患者进行了比较:1从中度AD开始接受美金刚治疗(进入模型的时期)并持续至病情发展到重度AD的患者;2仅从重度AD开始接受美金刚治疗的患者。结果 5年后,从中度AD开始美金刚治疗的患者中,较少的患者发展至重度AD(49%),依赖他人(59%)或有激越行为(47%);相比对于从重度AD开始治疗的患者分别为58%、67%和55%。从中度AD开始美金刚治疗的全国总治疗费用(670亿人民币)低于从重度AD开始的费用(730亿人民币)。结论在中国,从中度AD开始使用美金刚治疗可以节省大量成本。 | 胡善联 于欣 Emilie Clay Mondher Toumi Dominique Milea | 2016 | 中国药物经济学2016，0，9： | 2 |
| 5 | Clinical management and associated costs for moderate and severe Alzheimer’s disease in urban China: a Delphi panel study显示文摘Background:Healthcare resource utilisation for Alzheimer’s disease(AD)in China is not well understood.This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in urban China and to define the amount and cost of healthcare resources used.Methods:A panel of 11 experts was recruited from urban China to participate in two rounds of preparatory interviews.In the first round,9 physicians specialised in dementia gave a qualitative description of the clinical management of AD patients.In the second round,2 hospital administrators were asked about the cost of AD management and care.Results from the interviews were discussed by the experts in a Delphi panel meeting,where consensus was reached on quantitative aspects of AD management,including the rate of healthcare resource utilisation,the respective unit costs and caregiving time.Results:Interviewees reported that mild AD is under-recognised in China;most patients are diagnosed with moderate to severe AD.Loss of independence and agitation/aggression are the main drivers for healthcare resource utilisation and contribute to a heavier caregiver burden.It was estimated that 70%moderate AD patients are independent/non-aggressive at the time of diagnosis,15%are independent/aggressive,10%are dependent/non-aggressive,and 5%are dependent/aggressive.Dependent/aggressive AD patients are more likely to be hospitalised(70–90%)than accepted in a nursing home(0–20%),while the opposite is true for dependent/non-aggressive patients(5–35%for hospitalisation vs.80%for nursing home).Independent AD patients require 1–3 hours/day of caregiver time,while dependent patients can require up to 12–15 hours/day.Experts agreed that AD complicates the management of age-related comorbidities,found in 70–80%of all AD patients,increasing the frequency and cost of hospitalisation.Conclusions:The Delphi panel approach was an efficient method of gathering data about the amount of healthcare resources used and associated costs for moderate and severe AD patients in urban China.The results of this study provide a useful source of information for decision makers to improve future healthcare policies and resource planning,as well as to perform economic evaluations of AD therapies. | Xin Yu Shengdi Chen Xiaochun Chen Jianjun Jia Chunhou Li Cong Liu Mondher Toumi Dominique Milea | 2015 | Translational Neurodegeneration2015，4，1： | 2 |
| 6 | Effect of crack opening on the local diffusion of chloride in cracked mortar samples显示文摘 | ISMAIL M TOUMI A FRANCOIS R | 2008 | Cement and Concrete Research2008，38，89： | 1 |
| 7 | Effect of crack opening on the local diffusion of chloride in cracked mortar samples 显示文摘 | Ismail M Toumi A Francois R | 2008 | Cement and Concrete Research2008，38，89： | 1 |
| 8 | Metaplastic breast carcinoma: A case report and systematic review of the literature 显示文摘 | Toumi Z Bullen C Tang A | 2011 | Pathol Int2011，61，10： | 1 |
| 9 | Annual Persistence in Observed and Modeled UK Precipitation显示文摘 | Tomsett A C Toumi R | 2001 | Geophysical Research Letters2001，28，20： | 1 |
| 10 | Auto- immune pancreatitis mimicking pancreatic cancer显示文摘 | Mohamed Hammami Faouzi Noomen Omar Toumi | 2011 | N Am J Med Sci2011，3，11： | 1 |
| 11 | Is iliotibial band syndrome really a friction syndrome显示文摘 | Fairclough J Hayashi K Toumi H | | 0，，： | 1 |
| 12 | New insights in- to the fimction of the vastus medialis with clinical implica- tions显示文摘 | Toumi H Poumarat G Benjamin M | 2007 | Medicine and Science in Sports and Exercise2007，39，7： | 1 |
| 13 | Effect ofCrack Opening on Carbon Dioxide Penetration in CrackedMortar Samples显示文摘 | ALAHMAD S TOUMI A VERDIER J | 2009 | Materials Structure2009，42，5： | 1 |
| 14 | p73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?显示文摘 | Ben Mahmoud LK Toumi AA Chaar I | 2009 | Tunis Med2009，87，： | 1 |
| 15 | Reactive oxygen species and exer- cise on bone metabolism: Friend or enemy? 显示文摘 | FILAIRE E TOUMI H | 2012 | Bone Spine2012，79，4： | 1 |
| 16 | Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis显示文摘 | Toumi R Abdelouhab K Rafa H | 2013 | Immunopharmacol Immunotoxicol2013，35，3： | 1 |
| 17 | Mode I crack propagation in concrete under fatigue: microscopic observations and modeling显示文摘 | Toumi A Bascoul A | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，26，： | 1 |
| 18 | Nasopharyngeal carcinoma in childhood and adolescence: analysis of a series of 32 patients treated with combined chemotherapy and radiotherapy 显示文摘 | Daoud J Toumi N Bouaziz M | 2003 | Eur J Cancer2003，39，16： | 1 |
| 19 | An influence of solar spectral variations on radiative forcing of climate显示文摘 | HAIGH J D WINNING A R TOUMI R | 2010 | Nature2010，467，： | 1 |
| 20 | The inflammatory response: friend or enemy for muscle injury 显示文摘 | Toumi H Best TM | 2003 | Br J Sports Med2003，37，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员