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| 1 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 2 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 3 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 4 | Long-term graft acceptance after rat liver allograft transplantation induced by application of CTLA4-Ig anddonor specific spleen cell administration 显示文摘 | Neumann UP Fischer U Schmitz V | 2002 | Transplant Proc2002，34，5： | 1 |
| 5 | Sediment capping in eutrophic lakes: Efficiency of undisturbed calcite barriers immobilize phosphorus 显示文摘 | Berg U Neumann T Donnert D | 2004 | Applied Geochemistry2004，19，11： | 1 |
| 6 | Neoplasms in budgerigars (Melop- sittacus undulatus): clinical pathomorphological and serological findings with special consideration of kidney tumours 显示文摘 | Neumann U Kummerfeld N | 1983 | Avian Pathol1983，12，3： | 1 |
| 7 | Lactation and stress显示文摘 | Heinrichs M Neumann I Ehlert U | 2002 | Protective effects of breastfeeding in human stress2002，5，： | 1 |
| 8 | Web-based remote rendering with ibrac (image-based rendering acceleration and 100eompression)显示文摘 | Yoon I Neumann U | 2000 | Computer Graphics Forum2000，19，3： | 1 |
| 9 | Interface between haustoria of parasitic members of the Scrophulariaceae and their hosts:a histochemical and immunocytochemical approach显示文摘 | Neumann U Vian B Weber HC | | 0，，： | 1 |
| 10 | Sediment capping in eutrophic lakes-efficiency of undisturbed calcite barriers to immobilize phosphorus 显示文摘 | Berg U Neumann T Donnert D | 2004 | Applied Geochemistry2004，19，： | 1 |
| 11 | Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus显示文摘 | Abd E1 Rahman S E1-Kenawy AA Neumann U Herrler G Winter C | 2009 | Avian Pathol2009，38，1： | 1 |
| 12 | Intra-aor-tic balloon counterpulsation in acute myocardial infarctioncomplicated by cardiogenic shock (IABP-SHOCK II): fi-nal 12 month results of a randomised, open-label trial显示文摘 | THIELE H ZEYMER U NEUMANN F J | 2013 | Lancet2013，382，9905： | 1 |
| 13 | Surgical techniques for resectable pancreatic cancer 显示文摘 | Bahra M Neumann U | 2008 | Recent Results Cancer Res2008，177，： | 1 |
| 14 | Protein transport in plant cells:in and out of the Golgi显示文摘 | Neumann U Brandizzi F | 2003 | Annals Botany2003，92，： | 1 |
| 15 | Esge-eesgfna guideline:Cleaning and disinfection in gastrointestinal endoscopy,update 2008显示文摘 | Belienhoff U Neumann CS Rey JF | 2008 | Endoscopy2008，40，： | 1 |
| 16 | Ultrasound for screening developmen- tal dysplasia of the hip: a European perspective显示文摘 | Dorn U Neumann D | 2005 | Curr Opin Pediatr2005，17，1： | 1 |
| 17 | ESGE-ESGENAGuideline : cleaning and disinfection in gastrointestinal endoscopy显示文摘 | Beilenhoff U Neumann CS Rey JF | 2008 | Endoscopy2008，40，11： | 1 |
| 18 | In- tra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP- SHOCK II): final 12 month resuhs of a randomised, open-label trial 显示文摘 | THIELEH ZEYMER U NEUMANN F J | 2013 | Lancet2013，9905，： | 1 |
| 19 | Approaches to largescale urban modeling显示文摘 | HU J YOU S NEUMANN U | 2003 | IEEE Computer Graphics and Applications2003，23，6： | 1 |
| 20 | Elimination of microcystin peptide toxins from water by reverse osmosis显示文摘 | Neumann U Weckesser J | 1998 | Toxieol and Water Qual1998，13，2： | 1 |
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