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| 1 | Cirrhotic ascites review: Pathophysiology, diagnosis and management显示文摘Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities. | Christopher M Moore David H Van Thiel | 2013 | World Journal of Hepatology2013，5，5： | 13 |
| 2 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 3 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 4 | 采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果显示文摘目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ISH与RDN反应的可能交互作用。 | Fengler K Rommel KP Lapusca R Blazek S Besler C Hartung P von Roeder M Kresoja KP Desch S Thiele H Lurz P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，7： | 2 |
| 5 | Inhibition of pyruvat-edehydrogenase complex by moniliformin显示文摘 | Gathercole P S Thiel P G Hofmeyr J H S | 1986 | Biochemical Journal1986，233，： | 1 |
| 6 | Evidence for the presence of two novel pestivirus species 显示文摘 | Avalos-Ramirez R Orlich M Thiel H J | 2001 | Virology2001，286，： | 1 |
| 7 | Molecular signals for anaerobic methane oxidation in Black Sea seep carbonates and a microbial mat 显示文摘 | Thiel V Peckmann J Richnow H H Luth U Reitner J Michaelis W Peckmann J | 2001 | Mar Chem2001，73，2： | 1 |
| 8 | Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and my-ocardial reperfusion injury in unselected patients with ST-segment ele-vation myocardial infarction undergoing primary percutaneous coronary intervention:the LIPSIA显示文摘 | Thiele H Hildebrand L Schirdewahn C | | 0，，： | 1 |
| 9 | Operational tests on HVDC thyristor modules in a synthetic test circuit for the sylmar east restoration project显示文摘 | Bauer T Lips H P Thiele G | 1997 | IEEE Trans on Power Delivery1997，12，3： | 1 |
| 10 | Heterozygous de-novo mutations in ATP1 A3 in patients with alternating hemiplegia of child- hood: awhole-exome sequencing gene-identification study 显示文摘 | Rosewich H Thiele H Ohlenbusch A | 2012 | Lancet Neurol2012，11，9： | 1 |
| 11 | Interplay between pro- moter and structural gene variants control basal serum level of man- nan - binding protein 显示文摘 | MADSEN H O GARRED P THIEL S | 1995 | J Immunol1995，155，6： | 1 |
| 12 | Hog cholera virus:molecular composition of virions from pestivirus显示文摘 | Thiel H J Stark R Weiland E | 1991 | J Virol1991，65，： | 1 |
| 13 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral arterial bypass assistance显示文摘 | Thiele H Lauer B Hambrecht R | 2001 | Circulation2001，104，： | 1 |
| 14 | Copper-specific transcriptional repression of yeast genes encoding crit-ieal components in the copper transport pathway显示文摘 | Labbe S Zhu H W Thiele D J | 1997 | J Biol Chem1997，272，15： | 1 |
| 15 | Inunediate primary transcatheter closure of postinfarction ventricular septal defects 显示文摘 | Thiele H Kaulfersch C Daehnert I | 2009 | Eur Heart J2009，30，： | 1 |
| 16 | Pathogenesis of mucosal disease: acytopathic pestivirus generated by an internal deletion显示文摘 | Tautz N Thiel H J Dubovi E J | 1994 | Virology1994，68，： | 1 |
| 17 | Intra-aor-tic balloon counterpulsation in acute myocardial infarctioncomplicated by cardiogenic shock (IABP-SHOCK II): fi-nal 12 month results of a randomised, open-label trial显示文摘 | THIELE H ZEYMER U NEUMANN F J | 2013 | Lancet2013，382，9905： | 1 |
| 18 | Genetic map of the calicivirus rabbit hemorrhagic disease virus as deduced from in vitro translation studies显示文摘 | Wirblich C Thiel H J Meyers G | 1996 | J Virol1996，70，11： | 1 |
| 19 | Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV versus IC in ST-elevation myocardial infarction trial显示文摘 | Thiele H Schindler K Friedenberger J | 2008 | Circulation2008，118，1： | 1 |
| 20 | Classical swine fever virus: recovery of infectious viruses from cDNA constructs and generation of recombinant cytopathogenic defective interfering particles 显示文摘 | Meyers G Thiel H J Rumenapf T | 1996 | Journal of Virology1996，70，： | 1 |
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