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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt显示文摘AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre.METHODS:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian hospitals.Management consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of BCS.RESULTS:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) disorders.Fortythree percents had symptoms for less than one week with ascites as the most prevalent finding.Fourteen (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and diuretics.The median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver transplantation.Ascites control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered stents.Two died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to BCS.CONCLUSION:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation. | Anders Bay Neumann Stine Degn Andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk | 2013 | World Journal of Hepatology2013，5，1： | 5 |
| 3 | Recessively In herited Multiple Epiphyseal Dysplasia with Normal Stature,Club Foot and Double Layered Patella Caused by a DTDSTMutation显示文摘 | Superti Furga A Neumann I Riebel T | 1999 | J Med Genet1999，36，： | 1 |
| 4 | Pulmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast-enhanced three-dimensional magnetic resonance imaging显示文摘 | Dill T Neumann T Ekinci O | 2003 | Circulation2003，107，6： | 1 |
| 5 | Quality of life in patients with paroxysmal atrial fibrillation after catheter ablation: results of long--term follow-up 显示文摘 | Erdogan A Carlsson J Neumann T | 2003 | Pacing Clin Electrophysiol2003，26，3： | 1 |
| 6 | Annual cycles of water vapour and carbon dioxide fluxes in and above a boreal aspen forest显示文摘 | BLACK T A HARTOG G D NEUMANN H H | 1996 | Global Change Biology1996，2，： | 1 |
| 7 | Sediment capping in eutrophic lakes: Efficiency of undisturbed calcite barriers immobilize phosphorus 显示文摘 | Berg U Neumann T Donnert D | 2004 | Applied Geochemistry2004，19，11： | 1 |
| 8 | Experimental bronchial asthma-the strength of the species rat 显示文摘 | Tschernig T Neumann D Pich A | 2008 | Curr Drug Targets2008，9，6： | 1 |
| 9 | T cells with a CD4^+ CD25^+ regulatory phenotype suppress in vitro proliferation of virus - specific CDs + T cells during chronic hepatitis C virus infection显示文摘 | Boettler T Spangenberg HC Neumann - Haefelin C | 2005 | J Virol2005，79，12： | 1 |
| 10 | Activity of enzymes immobilized in colloidal spherical polyelectrolyte brushes 显示文摘 | Haupt B Neumann T Wittemann A | 2005 | Biomacromolecules2005，6，： | 1 |
| 11 | Synthetic 6-glucosyl phospholipid as a drug transport system 显示文摘 | Guerra F I Neumann J M Huynb-Dinh T | 1987 | Tetrahedron Lett1987，28，31： | 1 |
| 12 | Fast-growing, shallow-water ferromanganese nodules from the western Baltic Sea: origin and modes of trace element incorporation显示文摘 | HLAWATSCH S NEUMANN T Van den BERG C M G | 2002 | Marine Geology2002，182，： | 1 |
| 13 | Noninvasive monitoring using serum amyloid A and serum neopterin in cardiac transplantation 显示文摘 | Muller T F Vogl M Neumann M C | 1998 | Clin Chim Acta1998，276，1： | 1 |
| 14 | Mucinous neoplasms of the vermi form appendix,Pseudomyxoma peritonei and the new WHO clas- sification显示文摘 | Reu S Neumann J Kirchner T | 2012 | Pathologe2012，33，1： | 1 |
| 15 | Fibrosis progression after liver transplantation in patients with recurrent hepatitis C 显示文摘 | Neumann UP Berg T Bahra M | 2004 | J Hepatol2004，4，5： | 1 |
| 16 | Plmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast-enhanced three-dimensional magnetic resonance imaging显示文摘 | Dill T Neumann T Ekinci O | 2003 | Circulation2003，107，7： | 1 |
| 17 | How national andinternational financial development affect industrial R&D显示文摘 | Maskus K E Neumann R Seidel T | 2011 | European Economic Review2011，，6： | 1 |
| 18 | Diffusion-and perfusion-weighted MRI The DWI/PWI mismatch region in acute stroke显示文摘 | Neumann Haefelin T Wittsack HJ Wenserski F | | 0，，： | 1 |
| 19 | The trans- membrane domains of TNF-related apoptosis-inducing lig- and (TRAIL) receptors 1 and 2 co-regulate apoptotic sig- naling capacity显示文摘 | Neumann S Bidon T Branschadel M | 2012 | PLoS One2012，7，42： | 1 |
| 20 | Emergence and pandemic po tential ofswine-origin H1N1 influenza virus显示文摘 | Neumann G Noda T Kawaoka Y | 2009 | Nature2009，459，7249： | 1 |
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