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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Existence of Solutions of Nonlinear m-point Boundary Value Problems显示文摘 | RUYUN MA NELSON CASTANEDA | 2001 | J Math Anal Appl2001，255，： | 2 |
| 4 | Primary repair of penetrating colon injuries: a systematic review 显示文摘 | Singer MA Nelson RL | 2002 | Dis Colon Rectum2002，45，12： | 1 |
| 5 | Gastrointestinal carcinoid tumors-current management strategies显示文摘 | Memon MA Nelson H | 1997 | Dis Colon Rectum1997，40，9： | 1 |
| 6 | Molecular clo-ning of a Neurospora crassa carotenoid biosynthetic gene(Albino-3)regulated by blue light and the products of the white collar genes显示文摘 | Nelson MA Morelli G Garattoli A | | 0，，03： | 1 |
| 7 | Human cytomegalovirus persistence and latency in endothelial cells and macrophages显示文摘 | Jarvis MA Nelson JA | 2002 | Curr Opin Microbiol2002，5，4： | 1 |
| 8 | Mammalian sweet taste receptors显示文摘 | Nelson G Hoon MA Chandrashekar J | 2001 | Cell2001，，106： | 1 |
| 9 | Primary repair of penetrating colon injuries a systematic review 显示文摘 | Singer MA Nelson RL | 2002 | Dis Colon Rectan2002，45，12： | 1 |
| 10 | Acute effects of passive muscle stretching on sprint performance显示文摘 | Nelson AG Driscoll NM Landin DK Young MA Schexnayder IC | | 0，，： | 1 |
| 11 | Cardiac involvement in Behcet' s disease显示文摘 | Bowles AC Nelson MA Hammill CS | | 0，，： | 1 |
| 12 | Static stretching impairs sprint performance in collegiate track and field athletes显示文摘 | Winchester JB Nelson AG Landin D Young MA Schexnayder IC | | 0，，： | 1 |
| 13 | Outcomes of patients with do - not - intubate orders treated with noninvasive ventilation 显示文摘 | Levy M Tanios MA Nelson D | 2004 | Crit Care Med2004，32，10： | 1 |
| 14 | Primary repair of penetrating colon injuries: a systematic review显示文摘 | Singer MA Nelson RL | 2002 | Dis Colon Re- ctan2002，45，15： | 1 |
| 15 | Outcomes of patients with do-not-intubate orders treated with noninvasive ventilation显示文摘 | Levy M Tanios MA Nelson D | 2004 | Crit Care Med2004，32，10： | 1 |
| 16 | Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease 显示文摘 | Suk Ling Ma Nelson LS Tang Linda CW Lain | 2004 | Neurology2004，62，： | 1 |
| 17 | Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium显示文摘 | Fujimoto K L Ma Z W Nelson D M | 2009 | Biomaterials2009，30，26： | 1 |
| 18 | Lumbar spinal stenosis显示文摘 | Nelson MA | 1973 | J Bone Joint Surg1973，55，： | 1 |
| 19 | Economic Impact of El- derly Amenity Mobility in Southern China显示文摘 | Ambrose Ma Nelson W S Chow | 2006 | Journal of applied gerontology2006，25，4： | 1 |
| 20 | The palpated cranial rhythmic impulse (CRI): Its normative rate and examiner experience 显示文摘 | Sergueef N Greer MA Nelson KE | 2011 | Int J Osteopath Med2011，14，： | 1 |
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