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| 1 | The Association of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis显示文摘 | Nehmat Houssami Petra Macaskill M. Luke Marinovich Monica Morrow | 2014 | Annals of Surgical Oncology2014，，3： | 2 |
| 2 | Technical aspects of breast MRI—do they affect outcomes?显示文摘 | Ruth Warren Stefano Ciatto Petra Macaskill Richard Black Nehmat Houssami | 2009 | European Radiology2009，，7： | 1 |
| 3 | The prevention, detection, and management of breast cancer 显示文摘 | Nehmat Houssami Jack Cuzick J Michael Dixon | 2006 | The Medical Journal of Australia2006，184，5： | 1 |
| 4 | Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer显示文摘 | Meena S. Moran Stuart J. Schnitt Armando E. Giuliano Jay R. Harris Seema A. Khan Janet Horton Suzanne Klimberg Mariana Chavez-MacGregor Gary Freedman Nehmat Houssami Peggy L. Johnson Monica Morrow | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 5 | Staging the axilla in women with breast cancer: the utility of preoperative ultrasound-guided needle biopsy显示文摘Preoperative staging of the axilla in women with invasive breast cancer using ultrasound-guided needle biopsy(UNB) identifies approximately 50% of patients with axillary nodal metastases prior to surgical intervention. Although moderately sensitive, it is a highly specific staging strategy that is rarely falsely-positive, hence a positive UNB allows patients to be triaged to axillary lymph-node dissection(ALND) avoiding potentially unnecessary sentinel node biopsy(SNB). In this review, we extend our previous work through an updated literature search, focusing on studies that report data on UNB utility. Based on data for 10,934 breast cancer patients, sourced from 35 studies, a positive UNB allowed triage of 1,745 cases(simple proportion 16%) to axillary surgical treatment: the utility of UNB was a median 19.8% [interquartile range(IQR) 11.6%-26.7%] across these studies. We also modelled data from a subgroup of studies, and estimated that amongst patients with metastases to axillary nodes, the odds ratio(OR) for high nodal disease burden for a positive UNB versus a negative UNB was 4.38 [95% confidence interval(95% CI): 3.13, 6.13], P<0.001. From this model, the estimated proportion with high nodal disease burden was 58.9%(95% CI: 50.2%, 67.0%) for a positive UNB, whereas the estimated proportion with high nodal disease burden was 24.6%(95% CI: 17.7%, 33.2%) if UNB was negative. Overall, axillary UNB has good clinical utility and a positive UNB can effectively triage to ALND. However, the evolving landscape of axillary surgical treatment means that UNB will have relatively less utility where surgeons have modified their practice to omission of ALND for minimal nodal metastatic disease. | Nehmat Houssami Robin M. Turner | 2014 | Cancer Biology & Medicine2014，11，2： | 1 |
| 6 | Accuracy of fine needle aspiration cytology (FNAC) of axillary lymph nodes as a triage test in breast cancer staging显示文摘 | Stefano Ciatto Beniamino Brancato Gabriella Risso Daniela Ambrogetti Paolo Bulgaresi Cristina Maddau Patricia Turco Nehmat Houssami | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 7 | Radiological clinical trials: Proposal of a problem-finding questionnaire to improve study success显示文摘AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects. A final round of Delphi processes elucidated solutions to the identified problems.RESULTS Among 19/20(95%) respondents, 10(53%) were young physicians(under 35 years old), and the respondents included non-faculty members, fellows, residents, and undergraduate students. Ninety-four percent(18/19) of respondents showed interest in conducting clinical trials. On a scale of 1 to 10, the problems with higher/worse scores(8-9) were related to technical or communication problems. The most frequent problems across all studies were technical problems related to clinical trial equipment, insufficient willingness to participate, obstacles to understanding the design of electronic-case report form and extra work.CONCLUSION The developed questionnaire identified the main recurring problems in radiological clinical trials as perceived by endusers and helped define possible solutions that are mostly related to having dedicated clinical trial research staff. | Francesca Valdora Bianca Bignotti Massimo Calabrese Nehmat Houssami Alberto Tagliafico | 2016 | World Journal of Methodology2016，6，4： | 0 |
| 8 | Overdiagnosis of breast cancer in population screening:does it make breast screening worthless?显示文摘The risk of breast cancer(BC) overdiagnosis attributed to mammography screening is an unresolved issue, complicated by heterogeneity in the methodology of quantifying its magnitude, and both political and scientific elements surrounding interpretation of the evidence on this phenomenon. Evidence from randomized trials and also from observational studies shows that mammography screening reduces the risk of BC death; similarly, these studies provide sufficient evidence that overdiagnosis represents a serious harm from population breast screening. For both these outcomes of screening, BC mortality reduction and overdiagnosis, estimates of magnitude vary between studies however overdiagnosis estimates are associated with substantial uncertainty. The trade-off between the benefit and the collective harms of BC screening, including false-positives and overdiagnosis, is more finely balanced than initially recognized, however the snapshot of evidence presented on overdiagnosis does not mean that breast screening is worthless. Future efforts should be directed towards(a) ensuring that any changes in the implementation of BC screening optimize the balance between benefit and harms, including assessing how planned or actual changes modify the risk of overdiagnosis;(b) informing women of all the outcomes that may affect them when they participate in screening using well-crafted and balanced information; and(c) investing in research that will help define and reduce the ensuing overtreatment of screen-detected BC. | Nehmat Houssami | 2017 | Cancer Biology & Medicine2017，14，1： | 0 |
| 9 | 乳腺密度告知:需要有利大于弊的证据为今后的筛查工作提供参考显示文摘乳腺密度告知现状乳腺密度是乳腺癌发生的众多独立危险因素之一1。乳房筛查发现,人群中40%~50%的女性普遍乳腺致密(非均匀致密或极端致密)2,这使其成为最常见的乳腺癌发生的高危因素之一。除此之外,致密乳腺会增加女性在乳房X线照片上漏诊乳腺癌的风险,这意味着对于参与筛查的人来说,会延迟在下一次定期乳房X线照片被诊断为乳腺癌的间隔时间3。这是因为钼靶对于致密性乳腺的敏感性较低4。 | Brooke Nickel Rachel Farber Meagan Brennan Jolyn Hersch Kirsten McCaffery Nehmat Houssami 曹阿勇(译) 张宏艳(校) | 2021 | 英国医学杂志中文版2021，24，4： | 0 |
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