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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Cytology of bone marrow显示文摘 | Grindem C B Neel J A Juopperi T A | | 0，，： | 1 |
| 3 | Factors affecting natural development of soil on 35-year-old sulphide-rich mine tailings 显示文摘 | NEEL C BRIL H COURTIN-NOMADE A | 2003 | Geoderma2003，111，： | 1 |
| 4 | Two human c-onc genes are located on the long arm of chromosome 8 显示文摘 | Neel B G Jhanwar S C Chaganti R S Hayward W S | 1982 | Proc Natl Acad Scl USA1982，79，24： | 1 |
| 5 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 6 | Human immunodeficiency virus: SIV infection in wild gorilla 显示文摘 | Van Heuverswyn F Li Y Neel C | 2006 | Nature2006，444，7116： | 1 |
| 7 | High prevalence of methicillin resistant Staphylococcus aureusin pigs显示文摘 | De Neeling A J Van den Broek M J M Spalburg E C | 2007 | Vet Microbiol2007，122，： | 1 |
| 8 | New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3 - kinase/AKT pathway 显示文摘 | CANTLEY L C NEEL B G | 1999 | Proc Natl Acad Sci USA1999，96，8： | 1 |
| 9 | JNK1 in hematopoietically derived cells contributes to diet - induced inflammation and insulin re- sistance without affecting obesity 显示文摘 | Solinas G Vilcu C Neels JG | 2007 | Cell Metabolism2007，6，5： | 1 |
| 10 | Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust显示文摘 | Van den Eede N Dirtu A C Neels H | 2011 | Environment International2011，37，2： | 1 |
| 11 | New insights into tumor suppression:PTEN suppression tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway显示文摘 | CANTLEY L C NEEL B G | 1999 | Proc Natl Acad Sci USA1999，96，8： | 1 |
| 12 | Mo:lelling temperature and moisture effects on C-N transformations in soils: comparison of nine models 显示文摘 | Rodrigo A Recous S Neel C | 1997 | Ecological Modeling1997，102，23： | 1 |
| 13 | New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-ki- nase/AKT pathway 显示文摘 | Cantley L C Neel B G | 1999 | Proceedings of the National Academy of Sci- ences1999，96，8： | 1 |
| 14 | Behavior of class- level landscape metrics across gradients of class aggregation andarea显示文摘 | NEEL M C MCGARIGAL K CUSHMAN S A | 2004 | Landscape Ecology2004，19，： | 1 |
| 15 | Recreational exposure to microcystins during algal blooms in two California lakes 显示文摘 | BACKER L C MC NEEL S V BARBER T | 2010 | Toxicon2010，55，： | 1 |
| 16 | Fractional diffusion and reflective boundary condition显示文摘 | KREPYSHEVA N PIETRO L D NEEL M C | 2006 | Physica A2006，368，： | 1 |
| 17 | Parsimony in landscape metrics : Strength, universality, and consistency显示文摘 | Cushman S A McGarigal K Neel M C | 2008 | Ecological Indicators2008，8，5： | 1 |
| 18 | Patterns of allozyme diversity in the threatened plant Erigeron pariskii (Asteraeeae) 显示文摘 | Neel M C Ellstrand N C | 2001 | American Journal of Botany2001，88，5： | 1 |
| 19 | Factors affecting natural development of soil on 35-year-old sulphide-rich mine tailings显示文摘 | Neel C Bril H Courtin-Nomade A | 2003 | Geoderma2003，111，： | 1 |
| 20 | High prevalence of methicillin-resistant Staphylococcus aureus in pigs 显示文摘 | DE NEELING A J VAN DEN BROEK M J M SPALBURG E C | 2007 | Vet Microbiol2007，122，34： | 1 |
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