| 1 | Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical signifi cance显示文摘AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their in? uence on some clinical characteristics in patients with chronic HCV infection.METHODS: A total of 164 patients was investigated. Complete history, route of infection, assessment of al-cohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene se-quencing of 5’ NTR type-specifi c PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.7%, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in sub-jects older than 40 years, high viral load, more severe necro-in? ammatory activity, advanced stage of fi brosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive pre-dictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the geno-types 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abus-ers. Association of the subtype 1b with advanced liverdisease, higher viral load and histological activity sug-gests earlier infection with this genotype and eventually its increased pathogenicity. | Neda Svirtlih Dragan Delic Jasmina Simonovic Djordje Jevtovic Ljubisa Dokic Eleonora Gvozdenovic Ivan Boricic Dragica Terzic Sladjana Pavic Gorana Neskovic Sonja Zerjav Vladimir Urban | 2007 | World Journal of Gastroenterology2007，13，3： | 5 |
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