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| 1 | Bowel cleansing before colonoscopy:Balancing efficacy,safety,cost and patient tolerance显示文摘Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation adversely affects the adenoma detection rate and leads gastroenterologists to recommend earlier follow up than is consistent with published guidelines. Poor preparation affects as many as 30% of colonoscopies and contributes to an increased cost of colonoscopies. Patient tolerability is strongly affected by the preparation chosen and manner in which it is administered. Poor tolerability is,in turn,associated with lower quality bowel preparations. Recently,several new developments in both agents being used for bowel preparation and in the timing of administration have brought endoscopists closer to achieving the goal of effective,reliable,safe,and tolerable regimens. Historically,large volume preparations given in a single dose were administered to patients in order to achieve adequate bowel cleansing. These were poorly tolerated,and the unpleasant taste of and significant side effects produced by these large volume regimens contributed significantly to patients' inability to reliably complete the preparation and to a reluctance to repeat the procedure. Smaller volumes,including preparations that are administered as tablets to be consumed with water,given as split doses have significantly improved both the patient experience and efficacy,and an appreciation of the importance of the preparation to colonoscopy interval have produced additional cleansing. | Nicole M Harrison Michael C Hjelkrem | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 19 |
| 2 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 3 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 4 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 5 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 6 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 7 | Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study显示文摘 | Nicolás Jarufe Eduardo Figueroa César Mu?oz Fabrizio Moisan Julian Varas José R. Valbuena Claudia Bambs Jorge Martínez Fernando Pimentel | 2012 | HPB2012，，9： | 2 |
| 8 | T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression. | Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens | 2014 | World Journal of Nephrology2014，3，4： | 2 |
| 9 | Neuroprotection mediated by glial cell line-derived neurotrophic factor:Involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway显示文摘 | Nicole O Ali C Docagne F | 2001 | J Neurosci2001，21，9： | 1 |
| 10 | Optimal processing of human umbilical cord blood for clinical banking显示文摘 | Denning-Kendall P Donaldson C Nicol A Bradley B Hows J | 1996 | Exp Hematol1996，24，： | 1 |
| 11 | Silent synapses during development of thalamocortical input 显示文摘 | CRAIR M C NICOLL R A | 1997 | Neuron1997，18，： | 1 |
| 12 | Structural features of prolactins and growth hormones that can be related to their biological properties显示文摘 | Nicoll C S Mayer G L Russell S M | 1986 | Endocr Rev1986，7，： | 1 |
| 13 | Homozygosityfor a single base-pair mutation in the oocyte-specificGDF9 gene results in sterility in Thoka sheep显示文摘 | Nicol L Bishop S C Pong-Wong R | 2009 | Repro-duction2009，138，6： | 1 |
| 14 | Spontaneously hyper- tensive rats are highly vulnerable to AMPA-induced brain le- sions 显示文摘 | Lecrux C Nicole O Chaza'lviel L | 2007 | Stroke2007，38，11： | 1 |
| 15 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 16 | Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia 显示文摘 | Regine WF Courtney C | 2000 | J Neurosurg2000，93，3： | 1 |
| 17 | Antarctic krill (Euphausia superba) acquire a UV- absorbing mycosporine-like aminoacid from dietary algae显示文摘 | NEWMAN S J DUNLAP W C NICOL S | 2000 | Journal of Experimental Marine Biology and Ecology2000，255，： | 1 |
| 18 | Studies of larval life and metamorphosis in Ascidia nigra and species of Polyandrocarpa显示文摘 | GRAVE C NICOLL P A | 1939 | Carnegie Inst Wash Pub1939，517，： | 1 |
| 19 | Application of nanoscale zero valent iron (NZVI) for groundwater remediation in Europe 显示文摘 | Nicole C M Jurgen B Johannes B | 2012 | Environmental Science Pollution Research2012，19，2： | 1 |
| 20 | Ancient signals: comparative genomics of plant MAPK and MAPKK gene families 显示文摘 | Hamel L P Nicole M C Sritubtim S | 2006 | Trends Plant Sci2006，11，4： | 1 |
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