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| 1 | The catalytic activity of transition metal oxide nanoparticles on thermal decomposition of ammonium perchlorate显示文摘The catalytic proficiency of three MONs for AP thermal decomposition was studied in this work.A chemical co-precipitation method was used for synthesis of MONs(CuZnO,CoZnO,and NiZnO)and their characterization carried out by utilizing XRD,FTIR,and SEM.The TGA/DSC technique was employed for the investigation of the catalytic proficiency of MONs on the AP.The DSC data were used for measuring activation energy of catalyzed AP by using Ozawa,Kissinger,and Starink method.The MONs were much sensitive for AP decomposition,and the performance of AP decomposition was further improved.Among all the MONs,the CuZnO exhibits higher catalytic action than others and decomposition temperature of AP is descending around 117℃ by CuZnO.The reduction in the activation energy was noticed after the incorporation of MONs in AP. | Jalpa A. Vara Pragnesh N. Dave Shalini Chaturvedi | 2019 | Defence Technology(防务技术)2019，15，4： | 4 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | OIE 动物福利标准与多边贸易政策框架显示文摘本文介绍了OIE动物福利标准的工作进展,包括其制定程序、工作组情况、修订现状及成员国义务等,分析了GATT协定、WTO协定、SPS协议、TBT协议与动物福利的关系,阐述了动物福利私立标准与规范,介绍了OIE下一步的工作重点以及未来动物福利在国际贸易中产生的影响。 | Sarah Kahn Mariela Varas 李卫华(译) 刘飞(译) 周宏鹏(译) | 2017 | 中国动物检疫2017，34，3： | 2 |
| 4 | Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study显示文摘 | Nicolás Jarufe Eduardo Figueroa César Mu?oz Fabrizio Moisan Julian Varas José R. Valbuena Claudia Bambs Jorge Martínez Fernando Pimentel | 2012 | HPB2012，，9： | 2 |
| 5 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 6 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 7 | Hedghog singalingregulates differentiation from double-negative to doublepositive thymocyte显示文摘 | Outram SV Varas A Pepiceli CV | 2001 | Immunity2001，13，6： | 2 |
| 8 | Transendoscopic uhrasonography with miniprobes 显示文摘 | Abad R Varas M J Espinos JC | 2001 | Rev Esp Enferm Dig2001，93，4： | 1 |
| 9 | Stromal cell-derived factor 1/CXCR4 signaling is eritieal for early human T-cell development显示文摘 | Hernandez-Lopez C Varas A Sacedon R | 2002 | Blood2002，99，2： | 1 |
| 10 | Ghrelin increases anxiety- like behavior and memory retention in rats显示文摘 | Carlini VP Monzo n ME Varas MM | 2002 | Biochemical and Bioph- ysical Research Communications2002，299，5： | 1 |
| 11 | Modeling of mini-proinsulin production on Pichia pastoris using the AOX promoter显示文摘 | Jose M P Laura Varas | 2003 | Biotechnol Lett2003，22，： | 1 |
| 12 | Fluorescent protein-cell labeling and its application in time-lapse analysis of hematopoietic differentiation显示文摘 | Stadtfeld M Varas F Graf T | 2005 | Methods Mol Med2005，105，： | 1 |
| 13 | Sensitivity of peanut to timing of heat stress during reproductive development 显示文摘 | Vara Prasad P V Craufurd P Q Summerfield R J | 1999 | Crop Science1999，39，： | 1 |
| 14 | Diferential role of the h- ippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety like behavioral responses to ghrelin显示文摘 | Carlini VP Varas MM Craguolini AB | 2004 | Biochem Biophys Res Commun2004，313，3： | 1 |
| 15 | PI3K/Akt signalling pathway and cancer显示文摘 | Fresno Vara JA Casado E de Castro J | 2004 | Cancer Treat Rev2004，30，2： | 1 |
| 16 | Experimental Analysis of Fluid-filled Aluminium Tubes Subjected to High- velocity Impact显示文摘 | Vara D Lopez-Puente J | 2009 | International Journal of Impact Engineering2009，36，： | 1 |
| 17 | Experimental Analysis of Fluid- filled Aluminum Tubes Subjected to High- velocity Impact 显示文摘 | Varas D L6pez- Puente J Zaera R | 2009 | International Journal of Impact Engineering2009，36，1： | 1 |
| 18 | Leukaemia presenting with fulminant hepatic failure in a child显示文摘 | Kader A Vara R Egberongbe Y | 2006 | Pediatr Blood Cancer2006，47，： | 1 |
| 19 | Surgical acquired aganglionosis : myth or reality? 显示文摘 | Bag M J Saez T Varas J | 2014 | Pediatr Surg Int2014，30，8： | 1 |
| 20 | Biotechnological applications of serpentine soil bacteria for phytoremediation of tracemetals显示文摘 | Rajkumar M Vara Prasad M N Freitas H | 2009 | Crit Rev Biotechno2009，29，： | 1 |
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