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| 1 | Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling显示文摘 | Albert W Cheng Nathaniel Jillette Phoebe Lee Dylan Plaskon Yasuhiro Fuj iwara Wenbo Wang Aziz Taghbalout Haoyi Wang | 2016 | Cell Research2016，26，2： | 19 |
| 2 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 3 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 4 | Shifting equilibriums in Alzheimer’s disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis显示文摘Alzheimer's disease is the leading cause of dementia.Its increased prevalence in developed countries,due to the sharp rise in ageing populations,presents one of the costliest challenges to modern medicine.In order to find disease-modifying therapies to confront this challenge,a more complete understanding of the pathogenesis of Alzheimer's disease is necessary.Recent studies have revealed increasing evidence for the roles played by microglia,the resident innate immune system cells of the brain.Reflecting the well-established roles of microglia in reacting to pathogens and inflammatory stimuli,there is now a growing literature describing both protective and detrimental effects for individual cytokines and chemokines produced by microglia in Alzheimer's disease.A smaller but increasing number of studies have also addressed the divergent roles played by microglial neurotrophic and neurogenic factors,and how their perturbation may play a key role in the pathogenesis of Alzheimer's disease.Here we review recent findings on the roles played by microglia in neuroinflammation,neuronal survival and neurogenesis in Alzheimer's disease.In each case,landmark studies have provided evidence for the divergent ways in which microglia can either promote neuronal function and survival,or perturb neuronal function,leading to cell death.In many cases,the secreted molecules of microglia can lead to divergent effects depending on the magnitude and context of microglial activation.This suggests that microglial functions must be maintained in a fine equilibrium,in order to support healthy neuronal function,and that the cellular microenvironment in the Alzheimer's disease brain disrupts this fine balance,leading to neurodegeneration.Thus,an understanding of microglial homeostasis,both in health and across the trajectory of the disease state,will improve our understanding of the pathogenic mechanisms underlying Alzheimer's disease,and will hopefully lead to the development of microglial-based therapeutic strategies to restore equilibrium in the Alzheimer's disease brain. | Sophie C. Gray Kerri J. Kinghorn Nathaniel S. Woodling | 2020 | Neural Regeneration Research2020，15，7： | 13 |
| 5 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 6 | Histological changes of the testis and epididymis in adult rats as a result of Leydig cell destruction after ethane dimethane sulfonate treatment: a morphometric study显示文摘瞄准:由于睾丸激素分泌物的激烈的减小学习睾丸和附睾的组织学的变化到份量上。方法:十四只成年 Sprague-Dawley 老鼠与乙烷 intraperitoneally 被注射暗淡乙烷磺化(版本, 75 mg/kg ) 并且动物的一样的数字作为控制与生理盐水被注射。在天 7 和 12 (术后疗法) 分别地,从每个组的动物的一半被打死。睾丸和附睾被移开,织物块在 methacrylate 嵌入树脂。房间数字用立体声每睾丸被估计逻辑光 disector 和一些另外的参数用另外的 morphometric 方法被获得。结果:版本处理导致了 Leydig 房间的几乎完全的消除,但是没每睾丸在 Sertoli 房间的数字上有效果。在在版本处理以后的白天 7 点,许多伸长的 spermatids 在生精的上皮被保留,许多圆 spermatids 能在附睾管被看见。在白天 12 点, spermatids 和 spermatocytes 的更松开的安排变得明显,与在在向小管腔的一个近似光线的方向的生殖细胞之间被形成的明显的狭窄的空空格;数字(每睾丸) ,非类型 B,精原细胞和 spermatocytes 类似于控制类型 B,精原细胞增加了 59% ,并且早回合,伸长并且晚伸长的 spermatids 分别地在 37% , 72% 和 52% 减少了。结论:主要精子发生的损害追随者版本管理是(i) spermiation 失败,(i i ) spermatids 和 spermatocytes 的分开在精子形式和成熟分裂与缺陷联系了。 | Zheng-Wei Yang Ling-Shu Kong Yang Guo Jin-Qi Yin Nathaniel Mills | 2006 | Asian Journal of Andrology2006，8，3： | 12 |
| 7 | Significance of Shale Gas Development显示文摘Natural gas production from shale formations is growing exponentially in the United States. This paper introduces the five major shale formations in the United States and the technologies used to produce them. The Barnett, Haynesville, Fayetteville, Woodford, and Marcellus combined hold an estimated 978 trillion cubic feet of total gas reserves. These findings along with recent technological advances in horizontal drilling and completion methods have transformed the natural gas exploration and production industry in the U.S. and have fundamentally changed the U.S. energy picture. Specifically this paper states that the United States through the utilization of natural gas from shale can reduce its carbon emissions and can become more energy self-sufficient. Finally, the Harding & Shelton Group states in this paper that the opportunity to locate and produce shale gas in China is very similar to that which has taken place in the United States. | John Shelton Mike D. Burnaman Wenwu Xia Nathaniel Harding | 2009 | 中国石油勘探2009，14，3： | 9 |
| 8 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 9 | 中美钢铁工业能效对标研究显示文摘分析了中美钢铁工业的发展进程,提出了一种适用于不同国家间的钢铁工业能源效率对标的方法,考虑了影响能效的关键因素,如边界、能效指标、能源折算系数、电炉钢比等。采用该对标方法,对中美两国钢铁工业的能效进行了分析比较。结果表明:从两国钢铁工业整体能效对比分析来看,在设定相同的钢铁工业边界、能源折算系数和电炉钢比等条件下,中国钢铁工业的平均能源强度要比美国高约24.30kg/t;但从代表中国钢铁工业水平的重点钢铁企业与美国钢铁工业的能效对比分析来看,中国重点钢铁企业的能源强度要比美国钢铁工业约低59.70kg/t。 | 张春霞 上官方钦 郦秀萍 Lynn Price Nathaniel Aden Ali Hasanbeigi | 2013 | 钢铁2013，48，1： | 8 |
| 10 | 替比夫定的药代动力学研究显示文摘目的评价中国健康志愿者单次口服不同剂量替比夫定的药代动力学特征以及多次给药后的稳态血浆药代动力学。方法42名年龄在18~40岁的健康志愿者,男32名,女10名,随机分配到200、400、600、800mg 4个剂量组。其中600mg剂量组受试者接受单剂量和多剂量的研究。多剂量每日给药,持续8d。采用HPLC-MS/MS法测定给药前和给药后不同时间替比夫定的主血浆、尿液药物浓度,并据此计算药代动力学参数。结果在单次口服200、400、600、800mg片剂后,受试者的达峰时间分别为2.50、2.00、2.00h和2.50h;半衰期的平均值分别为(43.3±15.2)h、(49.1±14.4)h、(39.4±12.1)h和(46.7±20.8)h;血药达峰浓度平均值分别为(1 753.2±389.0)ng/ml、(2 586.7±871.4)ng/ml、(3 703.6±1 219.0)ng/ml和(3 454.6±953.9)ng/ml;曲线下面积的平均值分别为(12 843.2±2 925.6)ng·h ^(1·)ml^1、(22 948.9±5 721.0)ng·^(1·)ml^1、(26 440.5±8 938.1)ng·h ^(1·)ml^1以及(28 820.9±7 912.9)ng·h ^(1·)ml^1;血浆清除率(600mg)为(6 545.6±1 504.4)ml/h;多次给药后的稳态药代动力学研究结果显示,在600mg/d的给药剂量下,连续给药8d后,平均稳态药时曲线下面积为(26 123.9±7 196.3)ng·h ^(1·)ml^1,平均血药浓度为(1 088.5±299.8)ng/ml,血药达峰浓度和曲线下面积蓄积囚子分别为1.02±0.21和1.23±0.26。结论受试者口服替比夫定以后,吸收较为迅速,给药后的2~3h即达到峰值。在200mg至800mg剂量范围内,血浆中替比夫定的药代动力学参数均呈现出一定的规律。替比夫定在受试者体内有轻微蓄积。 | 江骥 胡蓓 王洪允 沈凯 Nathaniel A.Brown 周晓剑 | 2006 | 中华肝脏病杂志2006，14，11： | 8 |
| 11 | 体质指数与非吸烟女性肺癌关系的前瞻性队列研究显示文摘目的:研究体质指数(body mass index,BMI)与非吸烟女性肺癌的关系。方法:建立1997—2000年上海市区74942人(其中非吸烟者72829人)、年龄40~70岁的女性队列,每2年随访1次,至2007年12月共收集271例非吸烟女性肺癌病例。用COX回归模型分析BMI与非吸烟女性肺癌发生的相对危险度(relative risk,RR)和95%可信区间(95%confidence interval,95%CI)。结果:调整年龄、教育程度、绝经状态等因素后,基线BMI、20岁BMI与非吸烟女性肺癌危险均无关。基线BMI最高四分组与最低组比较,RR=0.95(95%CI:0.67~1.34);20岁BMI最高四分组与最低组比较,RR=0.77(95%CI:0.52~1.15)。基线BMI和年龄与非吸烟女性肺癌之间关系的分层分析得到相似结果。结论:40岁以上非吸烟女性的BMI可能与其肺癌发生的危险性没有关联。 | 陈伟 高玉堂 CHOW Wong-ho ROTHMAN Nathaniel 张薇 杨工 SHU Xiao-ou ZHENG Wei 项永兵 | 2009 | 肿瘤2009，29，5： | 6 |
| 12 | Using Genetic Algorithm Neural Network on Near Infrared Spectral Data for Ripeness Grading of Oil Palm(Elaeis guineensis Jacq.)Fresh Fruit显示文摘Genetic Algorithm Neural Network(GANN)for multi-class was used to predict the ripeness grades of oil palm fresh fruit using Near Infrared(NIR)spectral data.NIR spectral data provide sufficient information about compound structure of samples from the near infrared light that passes through.The variables used in the GANN modeling process were the new variables obtained as a result of dimensional reduction from original NIR spectral data using Principal Component Analysis(PCA).Three statistical measures such asMean Absolute Error(MAE),Root Mean Squared Error(RMSE)and the percentage(%)of good classification were used to assess adequacy of the GANN model.Based on the results,the GANN model created was precise enough to be used as the model calibration for this multi-class problem. | Divo Dharma Silalahi Consorcia E.Reano Felino P.Lansigan Rolando G.Panopio Nathaniel C.Bantayan | 2016 | Information Processing in Agriculture2016，3，4： | 5 |
| 13 | Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer显示文摘 | Shinichi Yabuuchi Shweta G. Pai Nathaniel R. Campbell Roeland F. de Wilde Elizabeth De Oliveira Preethi Korangath Mirte M. Streppel Zeshaan A. Rasheed Manuel Hidalgo Anirban Maitra N.V. Rajeshkumar | 2013 | Cancer Letters2013，，1： | 5 |
| 14 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 15 | Intermediate results of a prospective randomized controlled trial of traditional four-port laparoscopic cholecystectomy versus single-incision laparoscopic cholecystectomy显示文摘 | Melissa Phillips Jeffrey Marks Kurt Roberts Roberto Tacchino Raymond Onders George DeNoto Homero Rivas Arsalla Islam Nathaniel Soper Gary Gecelter Eugene Rubach Paraskevas Paraskeva Sajani Shah | 2012 | Surgical Endoscopy2012，，5： | 4 |
| 16 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 17 | Direct smelting process for stainless steel crude alloy recovery from mixed low-grade chromite, nickel laterite and manganese ores显示文摘 | Romie D. Laranjo Nathaniel M. Anacleto | 2018 | Journal of Iron and Steel Research(International)2018，25，5： | 4 |
| 18 | Species delimitation in the White-faced Cuckoo-dove(Turacoena manadensis) based on bioacoustic data显示文摘Background: The White-faced Cuckoo-dove(Turacoena manadensis) is a poorly-known Wallacean endemic with a limited distribution on Sulawesi and its satellites, including the Togian, Banggai and Sula archipelagoes. In 1900, populations from the Sula archipelago were awarded subspecies status T. manadensis sulaensis based on smaller size and minor differences in plumage; however, this distinction has not been corroborated subsequently, and T. manadensis is considered by most modern sources to be monotypic across its range.Methods: We conducted vocal analysis of the cuckoo-doves' main song using recordings collected from across the taxon's natural range. Descriptive information on the songs was obtained from the recordings using bioacoustic analysis software, after which several statistical methods were used to investigate differences in vocalizations among populations.Results: We report deep bioacoustic divergences in vocal trait pattern from across the cuckoo-doves' range, with birds from Peleng and Taliabu in the east having a different vocal trait pattern from birds from Sulawesi, Buton, and Togian in the west. These patterns agree with changes in landmass that accompanied the sea level fluctuations caused by Pleistocene glacial cycles, and indicate that eastern and western cuckoo-dove populations are at the level of different biological species.Conclusions: We propose that the eastern taxon be elevated to species level as T. sulaensis. Given the rampant degree of habitat destruction in its limited range, this taxonomic change will have important implications on the conservation status of T. sulaensis. | Nathaniel S.R.Ng Frank E.Rheindt | 2016 | Chinese Birds2016，，1： | 3 |
| 19 | 心肺复苏时使用喉罩通气所致的胃破裂显示文摘喉罩的应用在麻醉科气道管理上是一种根本性的变化,而且在用于复苏抢救时似乎也是如此。与面罩或支气管插管相比,它基本上既不需要太多技术也不需要培圳。。作为一种普运的设施.它在所有的医疗辅助部门和急诊科都有配备.在医院复苏抢救过程中其应用也越来越普及。使用喉罩行正压通气时,常见的并发症为漏气和胃膨胀,选二者部易被发现。下面列举一个院外心脏停搏后使用喉罩引起胃扩张、破裂及高度气腹的病例。 | Nathaniel Haslam G Claire Campbell John E Duggan James Cook 苏珊 | 2005 | 英国医学杂志中文版2005，8，2： | 3 |
| 20 | Environmental engineering of transition metal dichalcogenide optoelectronics显示文摘 | Trevor LaMountain Erik J. Lenferink Yen-Jung Chen Teodor K. Stanev Nathaniel P. Stern | 2018 | Frontiers of physics2018，13，4： | 3 |
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