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| 1 | Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis显示文摘AIM To investigate the effect of adipose-derived mesenchymal stem cells(ADMSCs)and their conditioned media(CM) on hepatocellular carcinoma(HCC) cell tumorigenesis.METHODS The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit8(commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Protein and mRNA expression was quantified by ELISA and real time PCR, respectively. Migration and invasion rates were performed by Transwell migration and invasion assays. Wound healing was examined to confirm the data obtained from the migration assays.RESULTS Our data demonstrated that when co-culturing HCC cell lines with ADMSCs or treating them with ADMSC CM, the HCC cell proliferation rate was significantly inhibited and the apoptosis rate increased. The decreased proliferation rate was accompanied by an upregulation of P53 and Retinoblastoma mRNA and a downregulation of c-Myc and hTERT mRNA levels. More notably, ADMSCs and their CM suppressed the expression of the two important markers of HCC carcinogenicity, alpha-fetoprotein and Des-gamma-carboxyprothrombin. In addition, the migration and invasion levels of HepG2 and PLC-PRF-5 cells significantly decreased, potentially through increased expression of the tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3.CONCLUSION These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis. | Rim Serhal Nagib Saliba George Hilal Mayssam Moussa Ghada S Hassan Oula El Atat Nada Alaaeddine | 2019 | World Journal of Gastroenterology2019，25，5： | 6 |
| 2 | Visual outcomes in patients with open globe injuries compared to predicted outcomes using the Ocular Trauma Scoring system显示文摘AIM: To determine the visual outcomes in adult patients who sustained open globe injuries and to determine whether the visual prognosis following an eye injury in an African setting differs from the predicted outcomes according to the Ocular Trauma Score(OTS)study. A secondary aim was to establish the evisceration rate for these injuries and assess how this form of intervention affected outcomes in comparison to the OTS.·METHODS: A prospective case series of all patients admitted with open globe injuries over a two-year(July2009 to June 2011) period. Injuries were scored using the OTS and the surgical intervention was recorded. The best corrected visual acuity at three months was regarded as visual outcome.· RESULTS: There were 249 open globe injuries, of which 169 patients(169 eyes) completed the 3-month follow-up. All patients underwent primary surgery, 175(70.3%) repairs, 61(24.5%) eviscerations and 13(5.2%)other procedures. Globe eviscerations were mainly done on OTS Category 1 cases, but outcomes in this category were not found to be different from OTS outcomes.Outcomes were significantly worse in Category 2, but when the entire distribution was tested, the differences were not statistically significant. The overall association between OTS outcomes and the final visual outcomes in this study was found to be a strong(P <0.005).· CONCLUSION: Reliable information regarding the expected outcomes of eye injuries will influence management decisions and patient expectations. The OTS is a valuable tool, the use of which has been validated in many parts of the world-it may also be a valid predictor in an African setting. | Nagib du Toit Hamza Mustak Colin Cook | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 3 | Chilling stress-induced proteomic changes in rice roots显示文摘 | Dong-Gi Lee Nagib Ahsan Sang-Hoon Lee Jeung Joo Lee Jeong Dong Bahk Kyu Young Kang Byung-Hyun Lee | 2008 | Journal of Plant Physiology2008，，1： | 2 |
| 4 | 杂交木薯消灭饥荒显示文摘作为世界第三大热量来源,木薯有潜力成为产量更高、营养更丰富的作物,改善发展中国家人们营养不良的问题。 | 纳吉布·纳萨尔(Nagib Nassar) 罗多米奥·奥尔蒂斯(Rodomiro Oniz) 张鹏(翻译) | 2010 | 环球科学2010，，6： | 2 |
| 5 | Recovery of Lead and Zinc from Fly Ash Generated from Municipal Incineration Plants by Means of Acid and/or Alkaline Leaching显示文摘 | Seham Nagib K Inoue | 2000 | Hydrometallurgy2000，56，： | 1 |
| 6 | A simple techniqueof distal limb perfusion during prolonged femoro-femoral cannu-lation显示文摘 | Madershahian N Nagib RsWippermann J | 2010 | J Card Surg2010，21，2： | 1 |
| 7 | Qualitative multi-model control using a learning approach显示文摘 | NAGIB G GHARIEBAND W BINDER Z | | 0，，06： | 1 |
| 8 | Recovery of Lead and Zinc from Fly Ash Generated from Municipal Incineration Plants by Maens of Acid and/or Alkaline Leaching显示文摘 | Seham Nagib K Inoue | 2000 | Hydrometallurgy2000，56，： | 1 |
| 9 | Role of progesterone receptor expression and proliferative activity in predicting the recurrence of meningioma显示文摘 | E1-Badawy NM Farid RM Nagib LN | 2013 | Egyp J Pathol2013，33，： | 1 |
| 10 | Enantioselectiveα-trifluoromethylation of aldehydes via photoredox organocatalysis显示文摘 | Nagib D A Scott M E Mac Millan D W C | 2009 | J Am Chem Soc2009，131，10： | 1 |
| 11 | The initial use of free-running electromyography to detect early motor tract injury during resection of intramedullary spinal cord lesions显示文摘 | Skinner SA Nagib M Bergman TA | 2005 | Neurosurgery2005，56，2： | 1 |
| 12 | Production of triploid cassava,Manihotesculenta Crantz by hybrid diploid gametes 显示文摘 | Nagib M Nassar A | 1991 | Field CropsResearch1991，30，： | 1 |
| 13 | The initial use of free-running electromyography to detect early motor tract injury during resection of intramedullary spinal cord lesions显示文摘 | Skinner S A Nagib M Bergman T A | 2005 | Neurosurgery2005，56，2： | 1 |
| 14 | Intramedullary cavernous angiomas of the spinal cord in the pediatric age group:a pediatric seriers显示文摘 | Nagib MG O'Fallon MT | 2002 | Pediatr Neurosurg2002，36，2： | 1 |
| 15 | Crystal structure determination of Lithium Amides 显示文摘 | NAGIB M JACOB H | 1972 | Z Anorg Allg Chem1972，391，3： | 1 |
| 16 | 查看详情显示文摘 | Cimbala J M Nagib HM Roshko A | | 0，，： | 1 |
| 17 | Atrial Tachycardia After Circumferential Pulmonary Vein Ablation of Atrial Fibrillation显示文摘 | Sanders Chae Hakan Oral Eric Good Sujoya Dey Alan Wimmer Thomas Crawford Darryl Wells Jean-Francois Sarrazin Nagib Chalfoun Michael Kuhne Jackie Fortino Elizabeth Huether Tammy Lemerand Frank Pelosi Frank Bogun Fred Morady Aman Chugh | 2007 | Journal of the American College of Cardiology2007，，18： | 1 |
| 18 | Recovery of Lead and Zinc from Fly Ash Generated from Municipal Incineration Plants by Means of Acid and/or Alkaline Leaching 显示文摘 | Nagib S Inoue K | 2000 | Hydrometallurgy2000，56，3： | 1 |
| 19 | Phase retarders with variable angles of internal reflection显示文摘 | Nagib N N | 1994 | Apple Opt1994，33，7： | 1 |
| 20 | Reversible atrioventricular block associated with closure of atrial septal defects using the Amplatzer device 显示文摘 | Kenji Suda Marie JR Nagib S | 2004 | J Am Coll Cardiac2004，43，： | 1 |
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