|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 在过敏 bronchopulmonary 麴菌病的胸 X 光线照相术、计算的 tomographic 表明显示文摘 AIM:To investigate the chest radiographic and high resolution computed tomography(HRCT)chest manifestations in glucocorticoid-naive allergic bronchopulmonary aspergillosis(ABPA)patients.METHODS:This is a prospective observational study and includes 60 consecutive glucocorticoid-naive patients with ABPA who underwent chest radiography and HRCT of the chest(1.25 mm every 10 mm)in the routine diagnostic workup for ABPA.RESULTS:Chest radiographs were normal in 50%of cases.Of the remainder,most patients demonstrated permanent findings in the form of parallel line and ring shadows suggesting bronchiectasis.Consolidation was detected in 17 cases but in the majority,the corresponding HRCT chest scan showed mucus-filled bronchiectatic cavities.Chest HRCT was normal in 22 patients,while central bronchiectasis(CB)was demonstrated in the remaining 38 patients.Bronchiectasis extended to the periphery in 33%-43%depending on the criteria used for defining CB.The other findings observed on HRCT were mucoid impaction,centrilobular nodules and high-attenuation mucus in decreasing order of frequency.CONCLUSION:Patients with ABPA can present with normal HRCT chest scans.Central bronchiectasis cannot be considered a characteristic feature of ABPA as peripheral bronchiectasis is commonly observed.Consolidation is an uncommon finding in ABPA. | Ritesh Agarwal Ajmal Khan Mandeep Garg Ashutosh N Aggarwal Dheeraj Gupta | 2012 | World Journal of Radiology2012，4，4： | 14 |
| 3 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 4 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 5 | Lens aldose reductase inhibiting potential of some indigenous plants显示文摘 | N Halder S Joshi S.K Gupta | 2003 | Journal of Ethnopharmacology2003，，1： | 2 |
| 6 | Classifying packets with hierarchical intelligent cuttings显示文摘 | Gupta P McKeown N | 2000 | IEEE Micro2000，20，1： | 2 |
| 7 | Packet classification on multiple fields显示文摘 | Gupta P McKeown N | 1999 | ACM SIGCOMM Computer Communication Review Archive1999，29，4： | 2 |
| 8 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | Occult tethered cord syndrome: a survey of practice patterns显示文摘 | Steinbok P Garton HJ Gupta N | 2006 | J Neurosurg2006，104，5： | 1 |
| 10 | Cytogenetic effects of cypermethrin and fenvalerate on the root meristem cells of A Ilium cepa显示文摘 | Chauhan L K S Saxena P N Gupta S K | 1999 | Environ Experi Botany1999，42，3： | 1 |
| 11 | Algorithms for Packet Classification显示文摘 | Gupta P McKeown N | 2001 | IEEE Network2001，15，2： | 1 |
| 12 | Application of RBF neual network to fault classification and location in transmission lines显示文摘 | Mahanty R N Dutta Gupta P B | 2004 | IEEE Proceedings on Gen- eration Transmission and Distribution2004，151，2： | 1 |
| 13 | Estimation of partial discharge parameters in gis using acoustic emission techniques显示文摘 | Gupta N Ramu T S | 2001 | Journal of Sound and Vibration2001，247，2： | 1 |
| 14 | Momentum transfer in curved pipes ( 2 ) : Non-Newtonian fluids 显示文摘 | Mishra P Gupta S N | 1979 | Ind Eng Chem Process Des1979，18，： | 1 |
| 15 | Investigation of flexural strength properties of rubber and nanoclay reinforced hybrid syntactic foams显示文摘 | Maharsia R Gupta N Jerro H D | 2006 | Mater Sci Eng A2006，417，12： | 1 |
| 16 | Graft copolymerization of 4-vinylpyridine and methyl acrylate onto polyethylene film by radiochemical method显示文摘 | MISRA B N GUPTA A | 1998 | J Appl Polym Sci1998，69，： | 1 |
| 17 | Current insights into the regulation of programmed cell death by NF-kappaB显示文摘 | Dutta J Fan Y Gupta N | 2006 | Oncogene2006，25，51： | 1 |
| 18 | Multi-Objective placement of electronic components using evolutionary algorithms显示文摘 | DEB K JAIN P GUPTA N | 2004 | IEEE Transactions on Components and Packaging Technologies2004，27，3： | 1 |
| 19 | Influence of polypropylene fiber geometry on plastic shrinkage cracking in concrete显示文摘 | BANTHIA N GUPTA R | 2006 | Cem Concr Res2006，36，7： | 1 |
| 20 | Crystallization of PP in PP/SEBS Blends and Its Correlation with Tensile Properties 显示文摘 | Gupta A K Purwat S N | 1984 | J Appl Polym Sci1984，29，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员