共被期刊论文引用了2次
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| 1 | Evaluation of corporal fibrosis in cadaveric pericardium and vein grafts for tunica albuginea substitution in rats显示文摘Aim: To evaluate the degree of corporal fibrosis in rats with cadaveric pericardium or vein as grafting materials for tunica albuginea substitution. Materials and methods: Thirty male Sprague-Dawley rats (300g~325g) were divided at random into 3 groups of 10 animals each: group 1 was the sham-operated controls and groups 2 and 3 underwent wedge excision of tunica albuginea and replacement with cadaveric pericardium and vein grafts,respectively. Four months later, rats were sacrificed and the penis removed to assess the degree of fibrosis using RTPCR technique for TGF-β1 mRNA expression. The tissues were fixed in 10% formalin, paraffin-embedded and stained with Masson's trichrome and Verhoff's van Giesen for collagen and elastic fibers. Results: Four monthsafter grafting, there was minimal fibrosis surrounding the patch in the vein graft rats and moderate fibrosis in the pericardial graft rats. The degree of penile fibrosis in the pericardial graft rats was significantly higher than that in the controls (P<0.01), but in the vein graft rats it was not significantly different from that of the controls (P>0.05).Conclusion: The degree of penile fibrosis of cadaveric pericardial graft was significantly higher than that of the control group, while in the vein graft group it was comparable to the latter. The authors believe that the vein graft may be a more ideal substance to be used as the tunica albuginea substitute than the pericardial graft in the surgical treatment of Peyronie's disease. | Somboon Leungwattanakij Vaewvadee Tiewthanom Wayne J.G. Hellstrom | 2003 | Asian Journal of Andrology2003，5，4： | 3 |
| 2 | Identification of potential biomarkers of Peyronie's disease显示文摘瞄准:为了识别是的蛋白质,在房间表示的差别作为与 Peyronie 的疾病(PD ) 有关源于正常和 diseased 大桶集成通信适配器白膜(TA ) 。方法:有成纤维细胞的特征的房间从二织物来源被孤立。当从一样的病人的通常出现的 TA 的磅房间,和那些被指定为 NT 房间,那些从有 PD 的病人的匾被指明。这些房间的送信人 RNA 被即时聚合酶链反应(RT-PCR ) 为单核白血球 chemoattractant 蛋白质 1 的表示(MCP-1 ) 分析。粗略的蛋白质 lysates 被提高表面的激光解吸附作用 / 电离团分光术(SELDIMS ) 与 IMAC30-Cu, CM10,和 H50 薄片分析。每溶解产物然后被分开成六部分,它被 SELDIMS 进一步分析。结果:RT- PCR 分析证明磅房间比他们的对应物 NT 房间表示了 MCP-1 的高水平。SELDIMS 分析证明所有四房间紧张的粗略的蛋白质 lysates 在 IMAC30-Cu 和 CM10 薄片上生产了类似、可再现的蛋白质侧面。有 fractionated lysates 的另外的 SELDIMS 分析检测了 11.6 kDa 的三蛋白质, 14.5 kDa,起来的 22.6 kDa 在磅房间和低的 kDa 和 46.9 kDa 在磅房间调整了的 6.3 的二蛋白质调整了。结论:MCP-1,经常涉及织物纤维变性,在 NT 房间比那在磅在高水平被表示。为 PD 的五个潜在的简历标记被 SELDIMS 分析识别。 | Gui-Ting Lin Zhong Wang Ben-Chun Liu Tom F. Lu Ching-Shwun Lin | 2005 | Asian Journal of Andrology2005，7，3： | 0 |
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