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| 1 | 青藏高原羌塘中部蓝片岩的地球化学特征及其构造意义显示文摘青藏高原羌塘中部的冈玛日 -桃形错地区蓝片岩被认为是板块构造边界的产物 ,通过对其主量元素、微量元素和稀土元素的地球化学特征的综合研究 ,其原岩属于洋岛型碱性玄武岩。再结合该地区的地质研究 ,表明在该地区存在一个古特提斯洋 。 | 邓希光 丁林 刘小汉 An Yin Paul A KAPP Michael A MURPHY Craig E MANNING | 2002 | 岩石学报2002，18，4： | 58 |
| 2 | 西藏及其周围地区地壳、地幔地震层析成像——印度板块大规模俯冲于西藏高原之下的证据显示文摘文中介绍有关西藏—喜马拉雅碰撞带的一项地震层析成像研究。根据一个用天然地震数据产生的全球波速模型 ,印度板块有可能以近水平状俯冲于整个西藏高原之下至 16 5~ 2 6 0km深度。西藏岩石圈具有低波速地壳和高波速下岩石圈 (75~ 12 0km深 )。在 12 0~ 16 5km深度范围 ,西藏岩石圈与俯冲的印度板块之间有一层低速软流圈物质。高原中部从地表到 310km深处有一低速体 ,说明地幔物质有可能穿过俯冲板块的脆弱部位上隆。这些结果以及野外实测的地壳缩短值说明高原的抬升得助于印度板块的近水平俯冲。我们推论俯冲印度板块的升温上浮以及上覆软流层的存在是造成西藏高原高海拔抬升以及内部地表仍相对平坦的主要原因。2 0 0 1年 1月 2 6日在印度西部发生的毁灭性大地震有可能是俯冲应力在印度板块后缘薄弱处引发的岩石圈大断裂。 | 周华伟 Michael A. MURPHY 林清良 | 2002 | 地学前缘2002，9，4： | 32 |
| 3 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 4 | Analysis of the current rib support practices and techniques in U.S. coal mines显示文摘Design of rib support systems in U.S. coal mines is based primarily on local practices and experience. A better understanding of current rib support practices in U.S. coal mines is crucial for developing a sound engineering rib support design tool. The objective of this paper is to analyze the current practices of rib control in U.S. coal mines. Twenty underground coal mines were studied representing various coal basins,coal seams,geology,loading conditions,and rib control strategies. The key findings are:(1) any rib design guideline or tool should take into account external rib support as well as internal bolting;(2) rib bolts on their own cannot contain rib spall,especially in soft ribs subjected to significant load—external rib control devices such as mesh are required in such cases to contain rib sloughing;(3) the majority of the studied mines follow the overburden depth and entry height thresholds recommended by the Program Information Bulletin 11-29 issued by the Mine Safety and Health Administration;(4) potential rib instability occurred when certain geological features prevailed—these include draw slate and/or bone coal near the rib/roof line,claystone partings,and soft coal bench overlain by rock strata;(5) 47% of the studied rib spall was classified as blocky—this could indicate a high potential of rib hazards; and(6) rib injury rates of the studied mines for the last three years emphasize the need for more rib control management for mines operating at overburden depths between 152.4 m and 304.8 m. | Mohamed Khaled M. Murphy Michael M. Lawson Heather E. Klemetti Ted | 2016 | International Journal of Mining Science and Technology2016，26，1： | 6 |
| 5 | A case study of multi-seam coal mine entry stability analysis with strength reduction method显示文摘In this paper,the advantage of using numerical models with the strength reduction method(SRM) to evaluate entry stability in complex multiple-seam conditions is demonstrated.A coal mine under variable topography from the Central Appalachian region is used as a case study.At this mine,unexpected roof conditions were encountered during development below previously mined panels.Stress mapping and observation of ground conditions were used to quantify the success of entry support systems in three room-and-pillar panels.Numerical model analyses were initially conducted to estimate the stresses induced by the multiple-seam mining at the locations of the affected entries.The SRM was used to quantify the stability factor of the supported roof of the entries at selected locations.The SRM-calculated stability factors were compared with observations made during the site visits,and the results demonstrate that the SRM adequately identifies the unexpected roof conditions in this complex case.It is concluded that the SRM can be used to effectively evaluate the likely success of roof supports and the stability condition of entries in coal mines. | Tulu Ihsan Berk Esterhuizen Gabriel S. Klemetti Ted Murphy Michael M. Sumner James Sloan Michael | 2016 | International Journal of Mining Science and Technology2016，26，2： | 5 |
| 6 | Analysis of roof and pillar failure associated with weak floor at a limestone mine显示文摘A limestone mine in Ohio has had instability problems that have led to massive roof falls extending to the surface. This study focuses on the role that weak, moisture-sensitive floor has in the instability issues.Previous NIOSH research related to this subject did not include analysis for weak floor or weak bands and recommended that when such issues arise they should be investigated further using a more advanced analysis. Therefore, to further investigate the observed instability occurring on a large scale at the Ohio mine, FLAC3 D numerical models were employed to demonstrate the effect that a weak floor has on roof and pillar stability. This case study will provide important information to limestone mine operators regarding the impact of weak floor causing the potential for roof collapse, pillar failure, and subsequent subsidence of the ground surface. | Murphy Michael M. Ellenberger John L. Esterhuizen Gabriel S. Miller Tim | 2016 | International Journal of Mining Science and Technology2016，26，3： | 5 |
| 7 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 8 | 美国社区学院和职业教育与培训的关系显示文摘美国的社区学院起始于100多年以前.那时候,几所最具声誉的大学领导人,在芝加哥大学校长WILLIAMRAINDY HARPER博士的影响下,开始探索中等与高等教育的衔接问题.他们认为,高等院校最初两年的教育与其后两年的教育相比,实际上与高中最后两年的教育更为接近.美国的教育体制包括四年的高中教育和四年的大学本科教育.象芝加哥大学那样的高等院校的办校宗旨是培养他们很多的学生进研究生院.HARPER校长认为,大学教育的重点应着重于本科大学后两年的教育,为学生进研究生院或专职学院作好准备. | MICHAEL MURPHY | 2001 | 职业技术教育2001，22，5： | 4 |
| 9 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 10 | Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 after liver transplant显示文摘 | Surakit Pungpapong Bashar Aqel Michael Leise K. Tuesday Werner Jennifer L. Murphy Tanisha M. Henry Kristen Ryland Amy E. Chervenak Kymberly D. Watt Hugo E. Vargas Andrew P. Keaveny | 2015 | Hepatology2015，，6： | 2 |
| 11 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 12 | Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial显示文摘 | Michael Miller Christopher P. Cannon Sabina A. Murphy Jie Qin Kausik K. Ray Eugene Braunwald | 2008 | Journal of the American College of Cardiology2008，，7： | 2 |
| 13 | Determination of volumetric changes at an underground stone mine: a photogrammetry case study显示文摘Photogrammetry,as a tool for monitoring underground mine deformation,is an alternative to traditional point measurement devices,and may be capable of accurate measurements in situations where technologies such as laser scanning are unsuited,undesired,or cost-prohibitive. An underground limestone mine in Ohio is used as a test case for monitoring of structurally unstable pillars. Seven pillars were photographed over in a 63 day period,punctuated by four visits. Using photogrammetry,point clouds of the mine geometry were obtained and triangulation surfaces were generated to determine volumes of change over time. Pillar spalling in the range of 0.29–4.03 m^3 of rock on individual rib faces was detected.Isolated incidents of rock expansion prior to failure,and the isolated failure of a weak shale band were also observed. Much of the pillars remained unchanged during the monitoring period,which is indicative of proper alignment in the triangulated surfaces. The photographs of some ribs were of either too poor quality or had insufficient overlap,and were not included. However,photogrammetry was successfully applied to multiple ribs in quantifying the pillar geometry change over time. | Slaker Brent Westman Erik Ellenberger John Murphy Michael | 2016 | International Journal of Mining Science and Technology2016，26，1： | 2 |
| 14 | Induced autophagy reduces virus output in dengue infected monocytic cells显示文摘 | Mingkwan Panyasrivanit Michael P. Greenwood David Murphy Ciro Isidoro Prasert Auewarakul Duncan R. Smith | 2011 | Virology2011，，1： | 2 |
| 15 | Concepts of blood transfusion in adults显示文摘 | Lawrence T Goodnough Jerrold H Levy Michael F Murphy | 2013 | The Lancet2013，，9880： | 2 |
| 16 | PerJbrmance Pay and Top Management Incentives显示文摘 | Jensen Michael C Murphy Kevin j | 1998 | Journal of Political Economy1998，20，： | 1 |
| 17 | The accurate determination of potassium and calcium using isotope dilution inductively coupled 'cold' plasma mass spectrometry显示文摘 | Karen E Murphy Stephen E Long Michael S Rearick | 2002 | J Anal2002，17，46： | 1 |
| 18 | Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice显示文摘 | Rachel A. Gioscia‐Ryan Thomas J. LaRocca Amy L. Sindler Melanie C. Zigler Michael P. Murphy Douglas R. Seals | 2014 | J Physiol2014，，12： | 1 |
| 19 | Compensation and Incentives: Practice vs Theory显示文摘 | George P Baker Michael C Jensen Kevin Murphy | 1988 | The Journal of Finance1988，，3： | 1 |
| 20 | A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic显示文摘 | Geoffrey F. Kelso Andrej Maroz Helena M. Cochemé Angela Logan Tracy A. Prime Alexander V. Peskin Christine C. Winterbourn Andrew M. James Meredith F. Ross Sally Brooker Carolyn M. Porteous Robert F. Anderson Michael P. Murphy Robin A.J. Smith | 2012 | Chemistry & Biology2012，，10： | 1 |
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