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| 1 | Ultrasound controlled interstitial high frequency thermotherapy(HFTT)-in vitro studies of the bovine liver显示文摘 | Hansler J Becker D Muller W | 1998 | Ultraschall Med1998，19，2： | 2 |
| 2 | A soluble form of TRAP (CD40ligand) is rapidly released after T cell activation显示文摘 | Graf D Muller S KorThauer U | 1995 | Eur J Immunol1995，，： | 2 |
| 3 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 4 | Neuroendocrine control of growth hormone secretion显示文摘 | Muller EE Locatelli V Cocchi D | 1999 | Physiological Reviews1999，79，： | 1 |
| 5 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H Ge N Catron D Buchanan M E | 2001 | Nature2001，410，： | 1 |
| 6 | Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression 显示文摘 | PATSOURIS D REDDY J K MULLER M | 2006 | Endocrinology2006，147，3： | 1 |
| 7 | Doubly fed induction generator systems for wind turbines显示文摘 | Muller S Deicke M Doncker R W D | 2002 | Industry Applications Magazine IEEE2002，8，3： | 1 |
| 8 | Lipodystrophia Ccbtrifugalis Abdominalis Infantilis in a 4-year-old Caucasian girl : associated with partial IgA deficiency and autoantibodies显示文摘 | Muller S Beissert S Metze D | 1999 | British Journal of Dermatology1999，140，6： | 1 |
| 9 | 3-D finite-element modeling of deformation and stress associated with faulting:effect of inhomogeneous crustal structures显示文摘 | Zhao S Muller R D Takahashi Y | 2004 | Geophys J Int2004，157，： | 1 |
| 10 | Hydrothermal ablation-a new simple method for coagulating endometrium in patients with therapy resistant recurring hypermenorrhea显示文摘 | Romer T Muller J Foth D | 2000 | Contrib Gynecol Obstet2000，20，： | 1 |
| 11 | Fermentation of fructans by epiphytic lactic acid bacteria显示文摘 | MULLER M LIER D | 1994 | J Appl Bacteriol1994，76，4： | 1 |
| 12 | Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery-results of a prospective trial显示文摘 | Rayes N Seehofer D Muller AR | 2002 | Z Gastroenterol2002，40，10： | 1 |
| 13 | Processable aqueous disper- sions of graphene nanosheets 显示文摘 | Li D Muller M B Gilje S | 2008 | Nat Nanotechnol2008，3，2： | 1 |
| 14 | A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling显示文摘 | Iwai H Kim M Yoshikawa Y Ashida H Ogawa M Fujita Y Muller D Kirikae T Jackson PK Kotani S | 2007 | Cell2007，130，4： | 1 |
| 15 | Processable aqueous disper- sions of graphene nanosheets 显示文摘 | Li D Muller M B Gilje S | 2008 | Nat Nanotechnol2008，3，2： | 1 |
| 16 | Effect of snesthesia on the cytokine responses to abdominal surgery显示文摘 | Crozier TA Muller JE Quttkat D | | 0，，03： | 1 |
| 17 | 查看详情显示文摘 | Li D Muller M.B Gilje S Richard B.K. Gordon G.W | | 0，，： | 1 |
| 18 | Genomic imprinting of IGF2 and H19 in human meningiomas显示文摘 | Muller S Zirkel D Westphal M | | 0，，： | 1 |
| 19 | Resistance change in memory structures integrating CuTCNQ nanowires grown on dedicated HfO2 switching layer显示文摘 | Muller C Deleruyelle D Müller R | 2011 | Solid State Electron2011，56，1： | 1 |
| 20 | Feasibility of single-source dual-energy computed tomography for urinary stone char-acterization and value of iterative reconstructions显示文摘 | Morsbach F Wumig MC Muller D | 2014 | Invest Ra-diol2014，49，3： | 1 |
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